Zorex Morning

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The drug Zorex Morning refers to non-steroidal anti-inflammatory drugs with a combined composition. Acetylsalicylic acid has an inhibitory effect on cyclooxygenase 1 and 2 and, as a result, disrupts the synthesis of prostaglandins , has anti-inflammatory , antipyretic , analgesic effects, and slows down platelet aggregation .

Sodium bicarbonate plays a large role in neutralizing free hydrochloric acid in the stomach. This is necessary to reduce the risk of negative consequences resulting from the use of acetylsalicylic acid.

The role of citric acid is to accelerate the absorption of the drug from the digestive tract.

Pharmacokinetics

At the present time, there are no data regarding the pharmacokinetics of the drug Zorex Morning.

Compound

Indications for use

Indications for use of the drug Zorex Morning include:

• headache that occurs in case of alcohol withdrawal syndrome ;
• mild or moderate manifestation of pain in adults, which has a different origin (for example, migraine , toothache , neuralgia , muscle pain );
• elevated body temperature with the development of colds or other infectious and inflammatory diseases (in persons over 15 years of age).

Directions for use and doses

Orally, 30 minutes before meals, without chewing, with water.

Hangover prevention: after drinking alcohol, 1 cap. (250 mg+10 mg) in the evening before bed.

Treatment of alcohol withdrawal syndrome: 1 caps. (250 mg+10 mg) 1–2 times a day. If necessary, the daily dose can be increased to 750 mg (sodium dimercaptopropanesulfonate), and the frequency of administration increased to 3 times a day. The drug should be taken for 3–7 days until the symptoms of intoxication cease.

For alcoholism: 1 caps. (150 mg+7 mg) 1–2 times a day, for 10 days.

For poisoning with arsenic compounds and salts of heavy metals: 300–1000 mg/day (as sodium dimercaptopropanesulfonate) in 2–3 doses, for 7–10 days.

Contraindications

Zorex Morning should not be taken if:

• erosive and ulcerative lesions of the gastrointestinal tract (during exacerbation), gastrointestinal bleeding ;
• “aspirin” asthma;
• combined use with the drug methotrexate at a dose of 15 mg per week;
• severe liver dysfunction;
• severe renal dysfunction;
• hemorrhagic diathesis (this group of diseases includes all types of hemophilia , telangiectasia , von Willebrand disease , hypoprothrombinemia , thrombocytopenic purpura , thrombocytopenia );
• dissecting aortic aneurysm;
• deficiency of glucose-6-phosphate dehydrogenase ;
• portal hypertension;
• pregnancy (during the 1st and 3rd trimester);
• breastfeeding;
• hypersensitivity to acetylsalicylic acid and other non-steroidal anti-inflammatory drugs .

The drug should not be prescribed as an antipyretic to those under 15 years of age, especially in cases of acute respiratory diseases caused by viruses, since in such cases there is a considerable risk of Reye's syndrome , which is manifested by encephalopathy and acute fatty liver , as well as rapid development of acute liver failure .

Caution should be exercised when using the drug in patients with hyperuricemia , urate nephrolithiasis , gout , gastric and duodenal ulcers (both in cases of exacerbations and if there is a history of mention of these diseases). The drug is also prescribed with caution in cases where the patient has heart failure in the stage of decompensation.

Side effects

The drug affects the body as a whole, so many body systems may exhibit unwanted symptoms caused by the side effects of the drug:

• Digestive system: Appetite may decrease significantly, abdominal pain, pain in the stomach area, nausea , vomiting , diarrhea , and signs of bleeding in the gastrointestinal tract may appear. Signs of bleeding may be obvious (for example, black stool, bloody vomiting), or they may be hidden. But in any case, there is a danger of developing iron deficiency anemia . It is also possible for erosive and ulcerative lesions of the gastrointestinal tract , even with perforation . In rare cases, liver dysfunction may occur, which is manifested by an increase in the level of hepatic transamin 3 and bilirubin .
• Central nervous system and sensory organs: Dizziness and tinnitus may occur. In cases where the drug is taken for a long period of time, headaches and visual and hearing disorders are likely to occur.
• Hematopoietic and hemostasis system: A side effect of the drug may be the development of aplastic anemia , agranulocytosis , pancytopenia , hemorrhagic syndrome , thrombocytopenia . If the medication has been taken for a long time, the level of platelet aggregation and the rate of blood clotting may decrease (development of hypocoagulation ).
• Urinary system: As a result of using high doses of the drug, hyperoxalaturia and the formation of urinary stones calcium oxalate the glomerular apparatus renal failure may develop ; and with prolonged use of the drug - papillary necrosis .
• It is also possible to develop allergic reactions: skin rash, angioedema , bronchospasm , Stevens-Johnson syndrome , toxic epidermal necrolysis (or Lyell's syndrome ).

Zorex

Zorex (unithiol + calcium pantothenate) is a combined complex-forming drug used to relieve withdrawal symptoms (in simple terms, without equivocation - hangover) and detoxification therapy for poisoning with various organic and inorganic compounds. Has hepatoprotective and antioxidant effects. Putting aside excessive politeness, it should be noted that in our country the problem of alcoholism, and even banal abuse of alcoholic beverages, is especially acute. It would not be an exaggeration to say that most of the male population of Russia (and, even more sadly, the female population) are familiar with hangovers firsthand. The development of withdrawal (hangover) syndrome is based on acetaldehyde, which is formed in the liver from ethanol under the action of the enzyme alcohol hydrogenase. The entry of this substance through the bloodstream into the brain, adrenal glands and a number of other vital organs and tissues causes such unpleasant symptoms as nausea, headache, depression, depression. It is all the more surprising that mankind’s centuries-long “experience” in drinking alcohol has never led to the creation of a truly “working” hangover remedy. And only in the middle of the last century the situation moved from a dead point. In the 50s of the 20th century, Russian scientists began to improve British anti-lewisite - an antidote for neutralizing the chemical warfare agent lewisite. The resulting compound was named unithiol. Its unique ability to bind the main toxic product of ethanol metabolism, acetaldehyde, was soon discovered. Subsequently, a tablet form of unithiol was synthesized and its high efficiency was confirmed. The logical conclusion of all the above-described scientific research was the creation of the original combination drug Zorex, which first appeared on the Russian pharmaceutical market in 2006.

Almost from the first years of its existence, Zorex began to gain whist in the eyes of drug addiction specialists and numerous lovers of strong drinks. In some sources, the creation of this drug was equated with the appearance of Viagra. Zorex has earned such a flattering comparison due to its wide therapeutic coverage: like Viagra, it is a lifeline for millions of men who do not know how to overcome a hangover.

After absorption in the gastrointestinal tract, unithiol enters the systemic bloodstream and is transported to the liver, where almost immediately, rolling up its sleeves, it begins to neutralize acetaldehyde with the formation of harmless compounds, thereby ensuring rapid and unhindered elimination of ethanol breakdown products from the body. In addition to this, unithiol activates a number of enzymes involved in the oxidation of the latter - alcohol dehydrogenase and acetaldehyde dehydrogenase. The second component of Zorex - calcium pantothenate - belongs to the B vitamins. It normalizes metabolism in neurons, stimulates the synthesis of glucocorticosteroids and takes part in the metabolism of proteins, lipids and carbohydrates, potentiating the detoxification effect of unithiol.

Zorex is available in capsules. It is recommended to take the drug half an hour before meals, without disturbing the integrity of the capsules, with a sufficient amount of liquid. To prevent a hangover, Zorex should be taken 1 capsule in the evening, before going to bed. To relieve hangover syndrome, the dosage regimen of the drug is as follows: 1 capsule 1-2 times a day, the maximum single dose is 3 capsules, the highest frequency of administration is 3 times a day. The duration of treatment is 3-7 days until the signs of toxicity disappear. For chronic alcoholism, Zorex is prescribed 1 capsule 1-2 times a day for 10 days.

Instructions for use of Zorex Morning tablets (Method and dosage)

Zorex Morning tablets are taken orally. To do this, dissolve the tablet in a glass of water and drink it. A single dose for adults and children over 15 years of age is 1-2 tablets with a break between doses of 4 to 8 hours. The maximum permissible dose per day is 8 tablets.

According to the instructions for Zorex Morning, the length of the treatment period should be no more than 7 days if the drug is prescribed as an analgesic, and not exceed 3 days if used as an antipyretic.

Nosological classification (ICD-10)

• F10.1 Harmful use of alcohol
• F10.2 Alcohol dependence syndrome
• F10.3 Withdrawal state
• T46.0 Poisoning with cardiac glycosides and similar drugs
• T56.1 Toxic effects of mercury and its compounds
• T56.2 Toxic effects of chromium and its compounds
• T56.3 Toxic effects of cadmium and its compounds
• T56.4 Toxic effects of copper and its compounds
• T56.5 Toxic effects of zinc and its compounds
• T56.8 Toxic effects of other metals
• T57.0 Toxic effects of arsenic and its compounds

Overdose

The first symptoms of an overdose are signs of excitation of the central nervous system, the appearance of dizziness, severe headache , gastralgia , ringing in the ears, decreased hearing acuity, dysfunction of the visual apparatus, nausea , vomiting , and shortness of breath . The following stages are characterized by a feeling of drowsiness, convulsive states , anuria , consciousness is depressed until the onset of coma , the development of respiratory failure , and disturbances in water-electrolyte metabolism.

If signs of poisoning appear, it is necessary to induce vomiting or rinse the stomach, then drink the required number of activated carbon or another drug with a similar effect, drink a laxative and seek help from a doctor. Further treatment is carried out in a specialized department.

Interaction

The drug has the property of increasing the toxicity of methotrexate , causing an increase in the effect of opioid painkillers , other non-steroidal anti-inflammatory drugs , heparin , some types of anticoagulants , sulfonamides , thrombolytics , platelet aggregation inhibitors , triiodothyronine , reserpine . It also reduces the effect of uricosuric drugs (these include benzbromarone and sulfinpyrazone ), drugs that lower blood pressure , and diuretics (for example, spironolactone , furosemide ).

The use of glucocorticosteroids , ethanol or ethanol-containing drugs together with Zorex Morning tablets causes an increase in the damaging effect on the mucous membrane of the gastrointestinal tract and increases the risk of gastrointestinal bleeding.

The drug increases the plasma concentration of barbiturates , digoxin , and lithium preparations.

The use of antacids that contain magnesium or aluminum hydroxide leads to slower and worsened absorption of acetylsalicylic acid.

Paracetamol increases the likelihood of developing unwanted side effects.

special instructions

Caution should be exercised when using the drug for people with a predisposition to gout , since acetylsalicylic acid , which is part of the medication, helps reduce the excretion of uric acid from the body, and this can provoke an acute attack of this disease.

If the drug is used for a long time, it is necessary to monitor the state of peripheral blood parameters, the functional state of the liver and check for the presence of hidden blood in a stool test.

It is worth remembering that one dose of Zorex Morning contains 933 mg of sodium, so it should be used with caution by people who are on a salt-free diet.