Buy MIG film-coated tablets 400 mg No. 20 in pharmacies

Pharmacodynamics and pharmacokinetics

Mig 400 tablets contain ibuprofen , which is an analgesic with antipyretic and anti-inflammatory properties. It indiscriminately inhibits COX-1 and COX-2 , as well as prostaglandin .

The analgesic properties of the drug are most pronounced in cases of inflammatory pain. The analgesic effect is not of the narcotic type.

After taking the tablets orally, the medicine is well absorbed from the gastrointestinal tract. The maximum plasma concentration of the active ingredient is reached approximately 120 minutes after taking tablets at a dosage of 400 mg.

99% bound to plasma The active component is slowly distributed in the synovial fluid . It is biotransformed in the liver through carboxylation and hydroxylation of the isobutyl group. Pharmacologically inactive metabolites .

Plasma half-life is 2-3 hours. in the form of metabolites and their conjugates . A small part of the drug is excreted unchanged in urine and bile.

How Mig works

The action of the drug is based on ibuprofen. This substance is from the group of non-steroidal anti-inflammatory drugs of the first group. Mig relieves pain well, especially pain in bones and joints, as well as headaches and toothaches, so it is often chosen as a painkiller for fractures and dislocations.

At the same time, due to its ability to relieve inflammation, Mig can be used as an analgesic for pain of inflammatory etiology.

An excellent antipyretic, Mig effectively reduces body temperature when needed. Acting directly on the thermoregulation center, it restores the processes of heat production and release. If you take a headache pill when your body temperature does not exceed normal values, the drug will not affect the thermometer readings.

It is important to remember that taking antipyretics is indicated only when the body temperature has risen above 38.5℃. Exceptions may be cases when the patient experiences febrile convulsions even at a value of 37℃.

Indications for use

The drug is indicated for use for:

• headache;
• toothache;
• pain in muscles and joints;
• fever due to colds and flu ;
• migraine;
• neuralgia;
• menstrual pain.

If you need to find out why Mig 400 tablets will help in each specific case, it is advisable to consult a doctor.

Indications for the use of Mig tablets

The main use of Miga is pain relief. Ibuprofen is effective for:

• migraines;
• toothache;
• muscle pain;
• neuralgia;
• periodic female pain;
• fever;
• headache.

Mig is often used for purulent otitis media, when the patient complains of pain and acute inflammation in the ear. The Miga tablet will relieve pain, which means you can sleep peacefully all night, but will not have any effect on the course of treatment for otitis media.

Contraindications

This product is prohibited for use when:

• hemorrhagic diathesis;
• hypersensitivity to the components of the drug;
• erosive and ulcerative lesions of the gastrointestinal tract;
• hemophilia and other bleeding ;
• pregnancy;
• under 12 years of age;
• breastfeeding;
• history of a negative reaction to acetylsalicylic acid and other NSAIDs ;
• aspirin asthma;
• bleeding;
• deficiency of glucose-6-phosphate dehydrogenase ;
• diseases of the optic nerve.

The medicine should be used with caution in the elderly, as well as in cases of arterial hypertension , liver or kidney failure , hyperbilirubinemia , gastritis , colitis , heart failure , liver cirrhosis with portal hypertension , nephrotic syndrome , gastric and duodenal ulcers (including a history ), enteritis , blood diseases.

Buy MIG film-coated tablets 400 mg No. 20 in pharmacies

Instructions for use MIG tab p.o 400 mg No. 20

Dosage forms tablets 400 mg Synonyms Dolgit Ibuprofen

Ibufen Nurofen

Pedea Faspik Group Anti-inflammatory drugs - derivatives of propionic acid International nonproprietary name Ibuprofen Composition Active substance: Ibuprofen. Manufacturers Berlin-Chemie AG/Menarini Group (Germany) Pharmacological action Anti-inflammatory, analgesic, antipyretic. Non-selectively inhibits two isoenzymes of cyclooxygenase. The maximum concentration is created after 0.5-1 hour. Slowly penetrates into the joint cavity, but lingers in the synovial tissue, creating higher concentrations in it than in plasma. Subject to biotransformation. Excreted by the kidneys. The anti-inflammatory effect is associated with a decrease in vascular permeability, improvement of microcirculation, decreased release of inflammatory mediators from cells and suppression of energy supply to the inflammatory process. The analgesic effect is due to a decrease in the intensity of inflammation, a decrease in the production of bradykinin and its algogenicity. A decrease in the excitability of the heat-regulating centers of the diencephalon results in an antipyretic effect. With a single dose, the effect lasts up to 8 hours. It has an antipyretic effect, the severity of which depends on the initial body temperature and dose. Reversibly inhibits platelet aggregation. Side effects : Dyspeptic disorders (nausea, heartburn, anorexia, vomiting, discomfort in the epigastric region, flatulence, diarrhea, constipation), erosive and ulcerative lesions of the gastrointestinal tract with signs of gastrointestinal bleeding, headache, dizziness, tinnitus, insomnia, agitation, visual disturbances (blurred vision, changes in color vision), fluid retention, edema, increased blood pressure, thrombocytopenia, granulocytopenia, hemolytic anemia, Quincke's edema, broncho-obstructive syndrome, allergic skin reactions. Indications for use : Rheumatoid arthritis, reactive synovitis in osteoarthritis deformans, psoriatic arthritis, acute joint attack in gout, ankylosing spondylitis (Bechterew's disease), cervical spondylosis, Barre-Lieu syndrome (cervical migraine, vertebral artery syndrome), lumbodynia, sciatica, thoracic radicular syndrome, bursitis, tenosynovitis, myalgia, neuralgic amyotrophy, occipital and intercostal neuralgia, ligament sprains, hematomas, trauma, pain in the surgical wound area, toothache, oral surgery, panniculitis, tonsillitis, pharyngitis, laryngitis, sinusitis, rhinitis , bronchitis, pneumonia, inflammatory processes in the pelvis, dysalgomenorrhea, colds, ARVI, febrile states, postural hypotension when taking antihypertensive drugs, nephrotic syndrome (to reduce the severity of proteinuria). Contraindications Hypersensitivity, peptic ulcer of the stomach and duodenum in the acute phase, nonspecific ulcerative colitis, aspirin-induced asthma, leukopenia, thrombocytopenia, hemorrhagic diathesis, severe dysfunction of the liver and kidneys, portal hypertension, arterial hypertension, heart failure, diseases of the optic nerve, scotoma , amblyopia, color vision impairment, pregnancy, breastfeeding. Directions for use and dosage : Inside. The dosage regimen is set individually depending on the indications. Overdose Symptoms: abdominal pain, nausea, vomiting, lethargy, drowsiness, depression, headache, tinnitus, metabolic acidosis, coma, acute renal failure, hypotension, bradycardia, tachycardia, atrial fibrillation and respiratory arrest. Treatment: gastric lavage (only during the first hour after administration), activated charcoal (to reduce absorption), alkaline drinking, forced diuresis and symptomatic therapy (correction of acid-base status, blood pressure, gastrointestinal bleeding). Interaction Reduces the antihypertensive activity of ACE inhibitors, the natriuretic activity of furosemide and hypothiazide. May increase the toxicity of methotrexate and lithium preparations. When combined with coumarin-type anticoagulants and alcohol, it increases the risk of hemorrhagic complications, and with tableted glucocorticoids - the risk of gastrointestinal bleeding. It is not recommended to use simultaneously with acetylsalicylic acid or other NSAIDs, antidiabetic drugs, phenytoin and hormonal contraceptives. Increases the concentration of digoxin in plasma. Caffeine enhances the analgesic effect of ibuprofen. Special instructions Considering the possibility of developing NSAID gastropathy, it is prescribed with caution to elderly people with a history of stomach ulcers and other gastrointestinal diseases, gastrointestinal bleeding, with simultaneous therapy with glucocorticoids, other NSAIDs and for long-term therapy. When symptoms of gastropathy appear, careful monitoring is indicated (including esophagogastroduodenoscopy, blood test to determine hemoglobin, hematocrit, stool test for occult blood). To prevent the development of NSAID gastropathy, it is recommended to combine it with PGE drugs (misoprostol). Prescribed with caution in children (up to 12 years), patients with severely impaired liver and kidney function (regular monitoring of bilirubin levels, transaminases, creatinine, renal concentrating ability is required), arterial hypertension and chronic heart failure (daily monitoring of diuresis, body weight , blood pressure). If visual impairment occurs, the dose should be reduced or the drug discontinued. It is not recommended to consume alcoholic beverages during treatment. Storage conditions : Protected from light, at room temperature.

Side effects

The use of Mig 400 can lead to the following adverse reactions:

• Gastrointestinal tract: vomiting, pain in the abdomen, loss of appetite , nausea, flatulence , heartburn , diarrhea , constipation ;
• sensory organs: dry or irritated eyes, decreased hearing, toxic damage to the optic nerve, ringing or noise in the ears, blurred or double vision, swelling of the conjunctiva and eyelids;
• CVS: heart failure , high blood pressure , tachycardia ;
• allergies : rash, Quincke's edema , dyspnea , anaphylactic shock , erythema multiforme , eosinophilia , itching , anaphylactoid reactions , bronchospasm , fever , Lyell's syndrome , rhinitis ;
• changes in laboratory parameters: increased serum creatinine concentration , increased bleeding time, decreased hemoglobin , decreased creatinine clearance liver transaminase activity serum glucose , decreased hematocrit ;
• respiratory organs: shortness of breath , bronchospasm ;
• CNS: insomnia , headache , nervousness, psychomotor agitation , depression , hallucinations , dizziness , anxiety, irritability, drowsiness , impaired consciousness ;
• urinary system: allergic nephritis , acute renal failure , cystitis , nephrotic syndrome , polyuria ;
• hematopoietic system: thrombocytopenic purpura , anemia , leukopenia , thrombocytopenia , agranulocytosis .

In rare cases, ulceration of the gastrointestinal mucosa, pain in the mouth, aphthous stomatitis , hepatitis , irritation or dryness of the oral mucosa, ulceration of the gum mucosa, pancreatitis , and aseptic meningitis .

With prolonged use of the drug in high doses, the likelihood of ulceration of the gastrointestinal mucosa, visual impairment, and bleeding increases.

Adverse reactions after taking Mig

Like any drug of the first group of non-steroidal anti-inflammatory drugs, Mig has a number of side effects. They appear more often in older people. Patients over 60 years of age are at risk. With frequent use of the drug, gastric bleeding may occur.

Exceeding a single dose can lead to swelling of the tongue, larynx and half of the face. Side effects from the digestive system include:

• nausea;
• dry mouth;
• diarrhea;
• lack of appetite;
• stool retention;
• flatulence;
• abdominal pain.

Patients with cardiovascular problems may experience tachycardia and surges in blood pressure. The following adverse reactions occur in the central nervous system:

• pain in the back of the head;
• sleep disorders;
• hallucinations;
• disturbances of consciousness;
• nervousness;
• coordination problems.

The urinary system may also react negatively to ibuprofen. While taking it, nephritis, kidney failure, tissue swelling, cystitis and polyuria occur.

Instructions for use Mig 400 (Method and dosage)

The medicine is used internally. For those who take Mig 400 tablets, the instructions for use indicate that dosages are set individually depending on the indications.

Usually start taking the medicine with 200 mg every day 3-4 times. If necessary, the dosage can be increased to 400 mg, which are taken 3 times a day. When the therapeutic effect is achieved, the daily dosage is reduced to 600-800 mg.

The instructions for use of Mig 400 advise that this product should not be taken for more than a week or in higher dosages without consulting a specialist.

In case of , heart or liver dysfunction, the dose is reduced.

Composition and release form

The active substance in Mig is ibuprofen. One tablet contains 400 mg of it. The auxiliary elements are:

• magnesium stearate;
• corn starch;
• silica;
• sodium carboxymethyl starch.

The drug is available in tablets. Each has an elongated oval shape. It is convex on both sides and has a score in the middle, which can be used to divide a single dose in half. The tablets are packaged in blisters. A cardboard box may contain 1 or 2 blisters.

Overdose

When using the drug in doses above normal, abdominal pain , vomiting, drowsiness , headaches, metabolic acidosis , acute renal failure , bradycardia , atrial fibrillation , nausea, lethargy, depression , tinnitus, coma , marked decrease in blood pressure, tachycardia , respiratory arrest are possible. .

If less than 60 minutes have passed since the overdose, gastric lavage . In addition, alkaline drinking, taking Activated Carbon , and forced diuresis . Treatment is symptomatic.

Interaction

When taking Mig 400, the effect of Furosemide and thiazide diuretics , which can be caused by sodium retention due to inhibition of prostaglandin .

In addition, the active ingredient of the drug may enhance the effect of oral anticoagulants . Taking them together is not advisable.

Ibuprofen also reduces the antiplatelet effect of acetylsalicylic acid and reduces the effectiveness of antihypertensive drugs.

Mig 400 should be used with caution in combination with NSAIDs and corticosteroids , as this can lead to adverse reactions from the gastrointestinal tract.

The drug also provokes an increase in the level of Methotrexate in the blood plasma .

In HIV-infected patients with hemophilia, the combination of ibuprofen with zidovudine increases the risk of hemarthrosis .

Combination with Tacrolimus increases the likelihood of nephrotoxicity due to inhibition of prostaglandin .

Under the influence of the drug Mig 400, the hypoglycemic properties of oral hypoglycemic drugs and Insulin are enhanced. Dosage adjustments may be necessary.