Essentiale forte N for restoration of liver cells capsules No. 30

The liver is the second organ after the brain that does not have nerve endings, and therefore does not generate pain in our body. Why then do we say: “My liver hurts or aches.” Similar sensations that occur in the right hypochondrium occur when the liver becomes inflamed or exposed to various kinds of diseases. Increasing in size or deforming, the capsule stretches, and the liver begins to put pressure on adjacent organs and tissues, causing discomfort. Even the slightest discomfort in this area, which lasts more than one or two days, is a reason to pay close attention to the gland and get help.

In this article we talk about Essentiale, a drug for the treatment and prevention of liver diseases. When, how and why to use it, when the effect occurs.

Liver diseases

The liver is a very powerful and the only filter of our body. Nature made sure that this filter is capable of self-healing, because it carries vital functions:

• Protective, or detoxifying, function of the liver. Some substances, such as barbiturates or alcohol, are completely destroyed in the liver. However, taking large doses of sleeping pills leads to damage to liver cells.
• Removing harmful substances from the body.
• Urea is formed in liver cells from ammonia. Urea from the liver travels through the bloodstream to the kidneys, from where it is excreted in the urine.
• Formation and production of bile. Bile promotes the absorption of fats in the small intestine and the neutralization of hydrochloric acid.
• The liver plays an important role in maintaining a constant blood composition.
• Accumulation of nutrients, vitamins and iron.

The liver clears the blood of bilirubin, the remnants of red blood cells that have outlived their 110-day life. The gland is most active from 1 to 3 am. The fact that she is not all right is indicated by such symptoms as: dry throat, bitterness in the mouth, pain in the right hypochondrium, inability to bend over, heaviness, dull or aching sensations, increased bloating, constant nausea, vomiting, lightening of the stool, change in its consistency, darkening of urine, change in skin color (yellowishness of the skin and sclera), the appearance of “red spider veins,” weight loss, enlargement of internal organs, determined by palpation.

Causes of liver disease

Viruses and bacteria. Viral diseases include hepatitis types A, B, C, D and others. They provoke acute and chronic inflammatory processes. In 57% of cases, hepatitis develops into cirrhosis of the liver. The causes of bacterial infections are usually echinococcus, alveococcus and roundworms, as well as leptospira - the causative agents of leptospirosis. The diseases also occur in acute or chronic form and in the form of cystic transformation of the liver.

Violation of fat metabolism. In this case, the content of lipids (fats) in the liver cells increases, which is why the iron may increase in size and lose its ability to function normally. This leads to the development of diseases such as fatty hepatosis (steatosis of the liver) and subsequently to cirrhosis. Disorders of fat metabolism in the liver in Russia affect about 27% of the population.

Alcohol abuse. Systematic excessive consumption of alcoholic beverages has a detrimental effect on liver cells, which over time can cause cirrhosis. Researchers have derived a relatively safe daily dose of ethanol-containing drinks: less than 30 ml of vodka (cognac, whiskey), 150 ml of wine or 250 ml of beer per day for women and 60 ml of vodka (cognac, whiskey), 300 ml of wine or 500 ml of beer per day - for men.

Toxic damage from drugs. Occurs as a result of uncontrolled use of medications, which leads to changes in liver tissue and disruption of its normal functioning. There are acute and chronic forms of toxic lesions. Chronic diseases arise due to the constant ingestion of doses of toxic substances into the body. They can be asymptomatic for years.

When metabolic processes in the liver and gallbladder are disrupted, stones can form. These gallstones do not cause any discomfort for the time being. But one day the disease may manifest itself in the form of “biliary colic,” when severe pain occurs due to a stone getting stuck in the bile duct. This condition can be life-threatening.

Contraindications and side effects

Contraindications to Essentiale, the instructions focus on this, relate exclusively to the patient’s individual intolerance to the components in the composition of the drug. This medicine may cause serious allergic reactions. In addition, a direct contraindication for Essentiale Forte, as the instructions for use indicate this, is age under 12 years. This is due to the high content of phospholipids. A contraindication to taking the drug is the period of lactation.

You should not take Essentiale Forte; the instructions warn about this in case of exacerbation of pancreatitis. If you experience any pain in the abdomen, you must consult a doctor before starting to take the drug.

Essentiale Forte, the instructions for use warn about this, has side effects. It must be remembered that when taking the drug in patients prone to hypotension, blood pressure may decrease. An overdose of the drug can provoke arrhythmia or tachycardia.

Sometimes when taking Essentiale Forten, the instructions for use indicate this, allergic reactions to the vitamins included in the product occur. Symptoms of this are most often a skin rash or watery eyes. In the first days of use, disruptions in the functioning of the digestive system may occur:

• Nausea.
• Discomfort in the abdomen.
• Stool disorder.

Composition of Essentiale

Essentiale is a complex of phospholipids from soybeans and choline (so-called essential phospholipids). Phospholipids are structural components of cell membranes. Contained in nervous tissue, they are involved in the delivery of fats, fatty acids and cholesterol. Any liver disease is, first of all, damage to the membranes of liver cells and their organelles, which leads to disturbances in the activity of enzymes and receptors associated with them, deterioration in the work and activity of liver cells and a decrease in the ability to regenerate.

Release form and dosage

The drug Essentiale is available in gelatin capsules and as an injection solution. The number of capsules per package can be 30, 90 and 180 pieces, ampoules per package - 5.

How Essentiale® Forte N works

Diseases and certain external factors (for example, alcohol and excess fatty foods) contribute to damage to liver cells (hepatocytes)1, 2. The worse the situation, the more difficult it is for the organ to perform its functions5. Essentiale® Forte N specifically promotes the restoration of hepatocytes4. This is all due to the fact that the active ingredient of the drug - essential phospholipids - is integrated into damaged liver cells. This contributes to their restoration, strengthening and increasing the elasticity of their membranes, as well as protection from toxins4, 8, 11. It is noteworthy that essential phospholipids are not only close in properties to the own lipids of liver cells, but also surpass them in activity due to the higher content of polyunsaturated (essential) fatty acids3, 6.

Indications for Essentiale

• chronic hepatitis; cirrhosis of the liver; fatty liver of various etiologies; toxic liver damage; alcoholic hepatitis; liver dysfunction in other somatic diseases;
• toxicosis of pregnancy;
• prevention of recurrence of gallstone formation;
• psoriasis (as an adjuvant therapy);
• radiation syndrome.

Treatment regimens

Take capsules orally with plenty of water.

The drug is suitable for use in adolescents over 12 years of age and adults. The recommended dosage is 2 capsules. 3 times a day with meals.

There are no restrictions on the duration of treatment from the manufacturer, but depending on the severity of the disease, it is important to consult with a specialist. Maintenance therapy on a regular basis is possible only if there are clear signs of improvement. In other cases, the advisability of taking the medicine or replacing it is determined by a specialist.

According to consumer reviews, a positive effect occurs in a short time (for mild ailments); for severe or complex forms of the disease, in order to achieve a lasting effect, you need to drink a minimum course of a month. Perhaps as part of complex therapy.

Contraindications

One of the main contraindications is a tendency to allergic reactions. The fact is that Essentiale capsules contain soybean oil in the shell, which can provoke severe allergic reactions in people prone to such. Otherwise, the drug is well tolerated, with the exception of individual reactions of the body to the components of the composition.

Essentiale forte N for restoration of liver cells capsules No. 30

A country

Germany
The country of production may vary depending on the batch of goods. Please check with the operator for detailed information when confirming your order.

Active substance

Phospholipids

Compound

Hard gelatin opaque capsules No. 1 are brown in color, containing an oily paste-like mass of yellowish-brown color. 1 capsule contains: active ingredient: phospholipids from soybeans, containing 76% (3-sn-phosphatidyl) - choline (synonyms: EPL, essential phospholipids ) – 300 mg; auxiliary ingredients: solid fat – 57,000 mg, soybean oil – 36,000 mg, hydrogenated castor oil – 1,600 mg, ethanol 96% – 8,100 mg, ethyl vanillin – 1,500 mg, 4-methoxyacetophenone – 0.800 mg, ?-tocopherol – 0.750 mg. Capsule composition: gelatin – 67.945 mg, purified water – 11.495 mg, titanium dioxide (E 171) – 0.830 mg, yellow iron oxide dye (E 172) – 2.075 mg, black iron oxide dye (E 172) – 0.332 mg, iron dye red oxide (E 172) – 0.198 mg, sodium lauryl sulfate – 0.125 mg. Release form: Capsules 300 mg. 10 or 15 capsules in a blister of PVC and aluminum foil, PVC/PTFE and aluminum foil or PVC/PE/PVDC and aluminum foil.1) 3 blisters of 10 capsules each with instructions for use in a cardboard box.2) 2 blisters of 15 capsules each with instructions for use in a cardboard box.

pharmachologic effect

PharmacodynamicsEssential phospholipids are the main elements of the structure of the cell membrane and cellular organelles. In liver diseases, there is always damage to the membranes of liver cells and their organelles, which leads to disturbances in the activity of enzymes and receptor systems associated with them, deterioration in the functional activity of liver cells and a decrease in the ability to regenerate. The phospholipids included in the drug Essentiale® forte N correspond to their chemical structure to endogenous phospholipids, but are superior to endogenous phospholipids in activity due to their higher content of polyunsaturated (essential) fatty acids. The integration of these high-energy molecules into damaged areas of hepatocyte cell membranes restores the integrity of liver cells and promotes their regeneration. The cis-double bonds of their polyunsaturated fatty acids prevent the parallel arrangement of hydrocarbon chains in the phospholipids of cell membranes; the phospholipid structure of the cell membranes of hepatocytes is “loosened,” which increases their fluidity and elasticity and improves metabolism. The resulting functional blocks increase the activity of enzymes fixed on membranes and contribute to the normal, physiological pathway of the most important metabolic processes. Phospholipids included in the drug Essentiale® forte regulate the metabolism of lipoproteins, transferring neutral fats and cholesterol to sites of oxidation, mainly due to the increase the ability of high-density lipoproteins to bind to cholesterol. Thus, there is a normalizing effect on the metabolism of lipids and proteins; on the detoxification function of the liver; to restore and preserve the cellular structure of the liver and phospholipid-dependent enzyme systems; which ultimately prevents the formation of connective tissue in the liver and promotes the natural restoration of liver cells. When phospholipids are excreted into bile, the lithogenic index decreases and bile is stabilized. Pharmacokinetics More than 90% of phospholipids taken orally are absorbed in the small intestine. Most of them are cleaved by phospholipase A to 1-acyl-lysophosphatidylcholine, 50% of which is immediately reverse acetylated into polyunsaturated phosphatidylcholine during the absorption process in the intestinal mucosa. This polyunsaturated phosphatidylcholine enters the bloodstream through the lymph and from there, mainly bound to high-density lipoproteins, enters the liver. Pharmacokinetic studies in humans were carried out using dilinoleyl phosphatidylcholine with a radioactive label (3H and 14C). The choline moiety was labeled with 3H, and the linoleic acid residue was labeled with 14C. The maximum concentration of 3H is reached 6-24 hours after administration and is 19.9% ​​of the prescribed dose. The half-life of the choline component is 66 hours. The maximum concentration of 14C is reached 4-12 hours after administration and is up to 27.9% of the prescribed dose. The half-life of this component is 32 hours. In feces, 2% of the administered dose of 3H and 4.5% of the administered dose of 14C are found, in urine - 6% of 3H and only a minimal amount of 14C. Both isotopes are more than 90% absorbed in the intestine.

Indications for use

— Chronic hepatitis, cirrhosis of the liver, fatty liver of various etiologies, toxic liver damage, alcoholic hepatitis, liver dysfunction in other somatic diseases. — Toxicosis of pregnancy. — Prevention of relapse of gallstone formation. — Psoriasis (as an adjuvant therapy).— Radiation syndrome.

Mode of application

Inside. The capsules should be swallowed whole with a sufficient amount of water (approximately 1 glass). For adolescents over 12 years of age and weighing more than 43 kg, as well as for adults, Essentiale® forte N is recommended to take 2 capsules - 3 times a day with meals. As a rule, , the duration of use is not limited.

Interaction

The interaction of the drug Essentiale® forte N with anticoagulants cannot be excluded. It is necessary to adjust the dose of anticoagulants when used together with Essentiale® forte N.

Side effect

The drug Essentiale® forte N is usually well tolerated by patients. According to the World Health Organization (WHO), side effects are classified according to their frequency of development as follows: very often (? 1/10), often (? 1/100, Contraindications Hypersensitivity to phosphatidylcholine , soy, soybeans or other ingredients of the drug. Children under 12 years of age (lack of sufficient evidence base). Use during pregnancy and breastfeeding Pregnancy The use of Essentiale® forte N during pregnancy is not recommended without medical supervision. There is not enough research. Period breastfeedingTo date, no risks have been identified when using products containing soy during breastfeeding.However, due to the lack of appropriate studies involving women during breastfeeding, the use of Essentiale® forte N during breastfeeding is not recommended.

Overdose

The use of Essentiale® forte N in doses exceeding the recommended ones may lead to increased side effects.

special instructions

Essentiale® forte N may cause severe allergic reactions because it contains soybean oil. Patients should be informed that taking Essentiale® forte N does not replace the need to avoid the damaging effects of certain substances on the liver (for example, alcohol). Supportive care phospholipids is justified only if the subjective signs of the condition improve during treatment. Patients should be advised to consult a physician if symptoms worsen or other unclear symptoms occur.

Special Recommendations

Essentiale and alcohol

Since alcohol has a well-known toxic effect on the body and liver cells, the use of Essentiale and alcohol intake become incompatible concepts. In addition, one should not assume that the drug is capable of providing a supportive and protective effect on the liver while taking alcohol-containing products. During treatment with Essentiale, it is recommended to refrain from drinking alcohol.

Essentiale and diet

Compliance with a strictly mandatory diet during the course of Essentiale is not a strict obligation, but only a recommendation. Any disease of the digestive organs and glands requires dietary nutrition. Because diet is the basis for a positive outcome in such diseases. During the acute period of the disease, the liver is especially vulnerable and it needs support “on all fronts.” So, you should maximally exclude from the diet foods that load the liver and disrupt the motility of the biliary tract: fatty and fried foods, exclude smoked and pickled foods, any dough and fresh baked goods, baked goods (for example, dried bread, crackers and biscuits in reasonable quantities), strong, rich soups with mushroom, fish or meat broths, offal, foods cooked on the grill or fire, canned food, legumes, spices.

Essentiale during pregnancy

The drug Essentiale is recommended during pregnancy as a means of relieving toxicosis and nausea syndromes. However, during this period it should be taken strictly on the recommendation of a specialist, excluding potential risks for both the fetus and the expectant mother. But during breastfeeding, this drug is contraindicated, since research in this area has not been conducted.

Indications for use

Essentiale is a plant-based drug. Its effectiveness for the treatment and prevention of various liver pathologies has been proven in practice. Essentiale, the instructions for use indicate this, improves the antitoxic function of the organ, restores cell membranes and prevents the appearance of connective tissue in tissues.

The medicine is prescribed for the complex treatment of various liver diseases, in particular:

• Cirrhosis.
• Hepatitis A

It allows you to restore the exchange of bile and cholesterol, as well as eliminate the consequences of poor nutrition and bad habits. When taking the drug, associated positive effects are observed:

• The risks of developing atherosclerosis and blood clots are reduced.
• The level of harmful cholesterol in the blood decreases.
• The condition of the skin improves.
• Digestive function is normalized.

The indication for the drug is severe toxicosis during pregnancy. As an adjuvant therapy, it is used in the treatment of radiation syndrome and psoriasis. Injections are prescribed to patients before operations on the abdominal organs and during the recovery period after them. This allows you to minimize the risk of complications.