Ibuprofen-Hemofarm (tablets)
The risk of side effects can be minimized if the drug is taken in a short course, at the minimum effective dose required to eliminate symptoms.
Elderly people experience an increased incidence of adverse reactions with NSAID use, especially gastrointestinal bleeding and perforation, in some cases fatal.
Side effects are predominantly dose-dependent.
The following adverse reactions were observed with short-term use of ibuprofen in doses not exceeding 1200 mg/day (6 tablets). When treating chronic conditions and with long-term use, other adverse reactions may occur.
The frequency of adverse reactions (ARs) listed below is listed according to the following classification: very common (≥ 10%), common (≥ 1% but < 10%), uncommon (≥ 0.1% but < 1%) , rare (≥ 0.01% but < 0.1%), very rare (< 0.01%), frequency unknown - frequency cannot be estimated from available data.
Blood and lymphatic system disorders
Very rare:
hematopoietic disorders (anemia, leukopenia, aplastic anemia, hemolytic anemia, thrombocytopenia, pancytopenia, agranulocytosis). The first symptoms of such disorders are fever, sore throat, superficial oral ulcers, flu-like symptoms, severe weakness, nosebleeds and subcutaneous hemorrhages, bleeding and bruising of unknown etiology.
Immune system disorders
Uncommon:
hypersensitivity reactions - nonspecific allergic reactions and anaphylactic reactions, reactions from the respiratory tract (bronchial asthma, including its exacerbation, bronchospasm, shortness of breath, dyspnea), skin reactions (itching, urticaria, purpura, Quincke's edema, exfoliative and bullous dermatoses, including toxic epidermal necrolysis (Lyell's syndrome), Stevens-Johnson syndrome, erythema multiforme), allergic rhinitis, eosinophilia.
Very rare:
severe hypersensitivity reactions, including swelling of the face, tongue and larynx, shortness of breath, tachycardia, arterial hypotension (anaphylaxis, Quincke's edema or severe anaphylactic shock).
Gastrointestinal disorders
Uncommon:
abdominal pain, nausea, dyspepsia (including heartburn, bloating).
Rare:
diarrhea, flatulence, constipation, vomiting.
Very rare:
peptic ulcer, perforation or gastrointestinal bleeding, melena, hematemesis, in some cases fatal, especially in elderly patients, ulcerative stomatitis, gastritis.
Frequency unknown:
exacerbation of colitis and Crohn's disease.
Disorders of the liver and biliary tract
Very rare:
liver dysfunction (especially with long-term use), increased activity of “liver” transaminases, hepatitis and jaundice.
Renal and urinary tract disorders
Very rare:
acute renal failure (compensated and decompensated), especially with long-term use, in combination with an increase in the concentration of urea in the blood plasma and the appearance of edema, hematuria and proteinuria, nephritic syndrome, nephrotic syndrome, papillary necrosis, interstitial nephritis, cystitis.
Nervous system disorders
Uncommon:
headache.
Very rare:
aseptic meningitis.
Cardiovascular disorders
Frequency unknown:
heart failure, peripheral edema, with long-term use there is an increased risk of thrombotic complications (for example, myocardial infarction), increased blood pressure.
Disorders of the respiratory system and mediastinal organs
Frequency unknown:
bronchial asthma, bronchospasm, shortness of breath.
Laboratory indicators
- hematocrit or hemoglobin (may decrease);
- bleeding time (may increase);
- plasma glucose concentration (may decrease);
- creatinine clearance (may decrease);
- plasma creatinine concentration (may increase);
- activity of “liver” transaminases (may increase).
If any of the side effects indicated in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.
On what could such statements be based?
In May 2021, the EMA Pharmacovigilance Risk Assessment Committee (PRAC) published a review of ibuprofen and ketoprofen following a survey by the French Agency for the Safety of Medicines and Health Products (ANSM), which indicated that the course of chickenpox and some other bacterial infections may be worsened by these medications. However, the instructions for medical use of NSAIDs already contain warnings that the anti-inflammatory effects of these drugs may hide the symptoms of exacerbation of infection.
The Lancet, one of the oldest and most respected medical journals, published a letter on March 11, 2021, which suggested that some anti-inflammatory drugs, such as ibuprofen, may increase the risk of complications of coronavirus infection by stimulating the rise of ACE-2. This letter caused a lively discussion, as it was not supported by any facts. Further research completely refuted it. This letter has now been withdrawn from the journal.
A little later, the European Medicines Agency EMA expressed its position. “ There is currently no scientific evidence linking ibuprofen to worsening health in patients with COVID-19. The EMA is closely monitoring the situation and will consider any new information that becomes available on this issue in the context of the pandemic. When initiating treatment for patients with COVID-19, healthcare providers should consider all available treatment options, including paracetamol and non-steroidal anti-inflammatory drugs, to reduce fever and pain. In accordance with EU national treatment guidelines, patients and healthcare professionals can continue to use non-steroidal anti-inflammatory drugs (such as ibuprofen) as prescribed. There is currently no reason for patients taking ibuprofen to interrupt their treatment based on the above. This is especially important for patients taking ibuprofen or other non-steroidal anti-inflammatory drugs to treat chronic conditions."
On March 19, 2021, the WHO stated a sudden change of position: " WHO is consulting with physicians treating patients with COVID-19 and is not aware of any reports of any negative effects of ibuprofen , other than the usual known side effects that limit it use in certain populations."
The Commission on Human Medicines Coronavirus (COVID-19) Expert Working Group concluded on 14 April 2021 that there is currently insufficient evidence to establish an association between the use of ibuprofen or other NSAIDs and worsening coronavirus infection . “Patients can take paracetamol or ibuprofen to self-treat COVID-19 symptoms such as fever and headache.”
The US Food and Drug Administration (FDA) also said it has no scientific evidence linking the use of NSAIDs such as ibuprofen to worsening COVID-19 symptoms.
Composition and release form
The medicine is available in several forms:
- pills;
- ointment;
- gel;
- candles;
- children's oral suspension.
The active substance is ibuprofen.
Auxiliary components in the tablets: potato starch, magnesium stearate, beeswax, sucrose.
Additional gel ingredients: ethanol, lavender oil, water.
Excipients in the ointment: macrogol.
Additional components of candles: solid fat.
special instructions
- Ibuprofen is prescribed in a short course - three days. If therapy lasts 10 days or more, you should consult a doctor.
- Elderly patients need to carefully monitor the tolerability of the drug, as they are more likely to experience side effects.
- May temporarily reduce female reproductive function (the effect disappears after discontinuation).
- It may affect the ability to drive vehicles, so if the patient notices lethargy or drowsiness, he should refrain from driving vehicles and other activities where reaction speed is required.
Ibuprofen for children
Interaction with other drugs
Ibuprofen was created back in 1953 and is therefore well studied. Here we will briefly list its interactions with common drugs - this is mainly a group of cardiovascular drugs, some antibiotics. A complete list of drug interactions should be read in the instructions for the drug.
- Reduces the effect of ACE inhibitors, beta-blockers and some diuretics, such as furosemide.
- The effect may be enhanced when taken with anticoagulants.
- The activity of amlodipine decreases.
- Caution should be used when taking warfarin, methotrexate and lithium together.
- Interactions have been noted with cardiac glycosides, quinolone antibiotics, ethanol, barbiturates, rifampicin, phenylbutazone, cyclosporine, mifepristone, tacrolimus, zidovudine, cefoperazone, cefotetan, valproic acid.
Note!
Description of the drug Ibuprofen 400 tablets. p/o 400 mg No. 50 on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
Ibuprofen ointment 5%
The drug is widely used as an external agent. Ointments and gels are produced in pure form or with the addition of cooling agents.
The ointment helps with arthritis, sprains, pain from damaged ligaments, back pain, sports injuries, and neuralgia.
How to use Ibuprofen ointment?
Usually the ointment is prescribed to adults and children over 14 years of age.
The dosage depends on the manufacturing company. A gel from 4 to 10 cm approximately contains 50 – 125 mg of the drug and this is a single dose. The product should be gently rubbed into the skin. Reapply no earlier than after 4 hours. The maximum daily dose is 500 mg.
Ibuprofen ointment
What forms does Ibuprofen come in?
In pharmacies you can find four dosage forms of the drug:
- If there are no contraindications related to the gastrointestinal tract, then people usually choose tablets or capsules.
- In cases where there is a stomach disease in the acute stage or the patient for some reason cannot swallow a tablet, suppositories are prescribed.
- Syrups are prescribed to infants. Most pediatricians prefer to reduce fever using Ibuprofen rather than Paracetamol, since the former acts faster and longer, and also has a lower safety profile due to the absence of toxic metabolites.
- For pain in the joints, muscles, back, and injuries, the ointment is ideal.
Instructions for taking Ibuprofen for adults and children.
- A single dosage for an adult is 200 mg; in case of severe pain, you can take 400 mg, the dosage frequency is 3-4 times a day, but not more than 1200 mg per day.
- A single dose for a child over 6 years old is 200 mg, can be taken 3-4 times a day. The maximum dosage for children per day differs by age as follows: for children 12-17 years old - 1000 mg; for children aged 6 to 12 years - 800 mg.
Ibuprofen Welfarm for adults
How many days can you take Ibuprofen?
The drug is taken for 2-3 days; if the patient’s condition does not improve or becomes worse, it is necessary to stop taking it and consult a doctor.
Contraindications:
- Hypersensitivity to the components of the drug.
- Bleeding disorders, hemophilia.
- Hematopoietic disorders.
- Erosive and ulcerative lesions of the gastrointestinal tract in the acute stage, bleeding in the gastrointestinal tract.
- Kidney or liver failure.
- Severe heart failure.
- The period after coronary artery bypass surgery.
- “Aspirin triad” (aspirin intolerance, nasal polyps and bronchial asthma).
- Diseases of the optic nerve.
- Caution should be exercised when taking other NSAIDs.
- Simultaneous use of medication and alcoholic beverages is not recommended.
