Composition of Solpadeine
- 1 tablet of Solpadeine contains 30 mg of caffeine , 8 mg of codeine phosphate hemihydrate , 500 mg of paracetamol . Auxiliary components: potassium sorbate, starch, cellulose, povidone, stearic acid, talc, ethanol 95%, magnesium stearate, hydroxypropyl methylcellulose, water, carmazine.
- 1 soluble tablet of Solpadeine contains 30 mg of caffeine , 8 mg of codeine phosphate hemihydrate , 500 mg of paracetamol . Auxiliary components: sorbitol , sodium bicarbonate, polyvidone, sodium lauryl sulfate, sodium saccharin, citric acid, sodium carbonate, dimethicone.
- 1 capsule of Solpadeine contains 30 mg of caffeine , 8 mg of codeine phosphate hemihydrate , 500 mg of paracetamol . Auxiliary components: magnesium stearate, propylene glycol, starch, titanium dioxide, gelatin, IMS 74 OP, red dye iron oxide, shellac, gelatin, water, butanol, isopropanol, black dye iron oxide.
Composition of Solpadeina Fast
- 1 tablet of Solpadein Fast (Solpadein Active) contains 60 mg of caffeine and 500 mg of paracetamol . Auxiliary components: sodium bicarbonate, sodium saccharinate, sorbitol, sodium lauryl sulfate, povidone, citric acid, dimethicone, sodium carbonate.
Note!
The description of the drug Solpadeine on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
Release form
White capsule-shaped tablets with red inscription "Solpadeine".
- 5 tablets in a blister - 1 or 2 blisters in a pack-cover made of plastic;
- 6 tablets in a blister - 1 or 2 blisters in a pack-cover made of plastic;
- 8 tablets in a blister - 1 blister in a pack-cover made of plastic or in a pack of paper;
- 12 tablets in a blister - 1 blister in a paper pack.
Soluble white flat tablets, scored on one side.
- 2 tablets per strip - 2, 4, 12, 6 or 30 strips in a paper pack.
Capsules with a red cap and a white body, with the black inscription “Solpadeine”, inside there is a white powder with crystalline inclusions.
- 6 capsules in a blister - 1 or 2 blisters in a pack of paper;
- 12 capsules in a blister - 1 blister in a pack of paper.
Soluble white tablets with beveled edges and a notch on one side.
- 2 tablets per strip - 2 or 6 strips in a paper pack;
- 4 tablets per strip - 6 strips per pack of paper.
Pharmacodynamics and pharmacokinetics
A drug of complex composition containing a combination of 3 active ingredients.
Paracetamol has an antipyretic and analgesic effect.
Caffeine demonstrates a general tonic effect (reduces drowsiness, weakens the feeling of fatigue, increases performance, increases heart rate, increases blood pressure during arterial hypotension ), stimulates the analgesic effect of Solpadeine.
Codeine has an analgesic effect and also improves pain tolerance.
Contraindications
- organic diseases of the circulatory system, including heart attack and atherosclerosis ;
- anxiety and panic disorders;
- attacks of tachycardia , ventricular extrasystole ;
- asthma ; cardiopulmonary failure; disorders accompanied by increased sputum production;
- arterial hypertension;
- sleep disorders;
- decompensated liver or kidney failure ;
- traumatic brain injury;
- blood disorders ( neutropenia, anemia, agranulocytosis, thrombocytopenia, hypocoagulation );
- increased intracranial pressure;
- pregnancy and lactation;
- allergy to the components of the drug;
- age up to 12 years;
- alcohol poisoning;
- epilepsy.
Solpadeine tablets should be prescribed with caution for viral hepatitis , benign hyperbilirubinemia, alcoholism , increased excitability, alcoholic damage to liver tissue, glaucoma , deficiency of glucose-6-phosphate dehydrogenase , tendency to seizures, and in old age.
Contraindications for use
The drug is not used in treatment for:
- congenital hyperbilirubinemia,
- dysfunctions in the kidneys and liver,
- alcoholism,
- hereditary intolerance to oligosaccharides,
- hypersensitivity in patients to the active and auxiliary substances of the drug,
- blood diseases,
- heart failure in decompensated form and acute myocardial infarction,
- paroxysmal tachycardia,
- increased arousal and sleep disorders,
- hypertension and atherosclerosis,
- glaucoma and hyperthyroidism,
- epilepsy and vascular spasms,
- acute pancreatitis,
- anemia, leukopenia and diabetes mellitus in severe forms,
- patients over 60 years old,
The medication is not prescribed to adolescents under 12 years of age. Doctors do not recommend taking the medicine:
- pregnant women, as there is a risk of miscarriage,
- mothers who breastfeed their babies, due to the entry of the medication into the milk.
Side effects
In the doses indicated below, the drug is well tolerated, but in some cases angioedema , skin rash, bronchospasm, and urticaria .
Codeine can cause: nausea, constipation , dizziness, vomiting, drowsiness, gastralgia , sleep disturbances, tachycardia .
Paracetamol can cause: agranulocytosis, leukopenia, thrombocytopenia, hemolytic anemia, methemoglobinemia, liver and kidney dysfunction (with long-term use in high doses).
Caffeine can cause: anxiety, agitation, headache, tachycardia , increased blood pressure, arrhythmias .
Prescription of medication
The medication is used to relieve symptoms:
- headache, dental, menstrual and muscle pain,
- migraine attacks,
- rheumatic diseases and neuralgia,
- pain due to inflammation of the throat and joints,
- pain that occurs after treatment and tooth extraction operations,
- fever after administering vaccines to a patient,
- elevated temperature due to colds and flu.
Solpadeine effervescent is dissolved in 0.5 cups of water cooled to room temperature. Solpadeine for toothache in fifteen minutes reduces the patient’s suffering during the day and before falling asleep and helps before visiting the dentist. Solpadeine for headaches is used at the onset of migraine attacks and changes in weather conditions. The medicine eliminates nausea, frontal and temporal pain in 10-20 minutes. Solpadeine for fever is used to reduce fever and intoxication during epidemics of colds and after vaccinations. Solpadeine at a temperature makes the patient feel better in 10-15 minutes and is prescribed for sinusitis and sore throat.
Instructions for use of Solpadeine (Method and dosage)
Solpadeine capsules and tablets, instructions for use
Persons over 16 years of age are recommended to take 1-2 tablets (effervescent tablets or capsules) up to four times a day, with an interval of at least four hours between doses. The largest permitted single dose is 2 tablets, the largest permitted daily dose is 8 tablets.
Children 12-16 years old are prescribed to take 1 tablet (effervescent tablet or capsule) up to 4 times a day with an interval of at least four hours between doses. The largest permitted single dose is 1 tablet, the largest permitted daily dose is 4 tablets.
The drug should be taken after meals. Soluble (or “effervescent”) Solpadeine must be diluted in a glass of water before taking.
You should not take the described drug for more than 5 days in a row when treating pain and more than 3 days in a row when treating fever.
Solpadeine Active (Solpadeine Fast), instructions for use
Solpadeine Fast effervescent tablets must be dissolved in a glass filled with water before taking.
Persons over 12 years of age are recommended to take 1-2 tablets up to four times a day, with an interval of at least four hours between doses. The largest permitted single dose is 2 tablets, the largest permitted daily dose is 8 tablets.
You should not take the described drug for more than 5 days in a row when treating pain and more than 3 days in a row when treating fever.
Solpadeine fast pain reliever, tablets, 12 pcs.
pharmachologic effect
An analgesic-antipyretic of a combined composition, contains a combination of two active ingredients: paracetamol and caffeine.
Has antipyretic and analgesic effects. Paracetamol blocks COX in the central nervous system, affecting the centers of pain and thermoregulation (in inflamed tissues, cellular peroxidases neutralize the effect of paracetamol on COX), which explains the almost complete absence of anti-inflammatory effect. The lack of influence on the synthesis of prostaglandins in peripheral tissues determines the absence of a negative effect on water-salt metabolism (sodium and water retention) and the gastrointestinal mucosa.
Caffeine stimulates the psychomotor centers of the brain, has an analeptic effect, enhances the effect of analgesics, eliminates drowsiness and fatigue, and increases physical and mental performance.
Composition and release form Solpadeine fast pain reliever, tablets, 12 pcs.
1 tab.:
- Active ingredients: paracetamol 500 mg,
- caffeine 65 mg.
Description of the dosage form
White film-coated tablets, capsule-shaped with a flat edge, embossed with a triangle and “+” sign on one side of the tablet.
Characteristic
Analgesic-antipyretic
Directions for use and doses
Before oral administration, Solpadeine Fast tablets should be dissolved in at least 100 ml (half a glass) of water.
Adults (including the elderly) and children over 12 years of age are prescribed 1-2 tablets. 3-4 times/day, if necessary. The interval between doses is at least 4 hours. The maximum single dose is 2 tablets, the maximum daily dose is 8 tablets.
The drug is not recommended for use for more than 5 days when prescribed as an analgesic and for more than 3 days as an antipyretic without prescription and medical supervision.
Increasing the daily dose of the drug or the duration of treatment is possible only under the supervision of a physician.
Pharmacodynamics
An analgesic-antipyretic of a combined composition, contains a combination of two active ingredients: paracetamol and caffeine. Has antipyretic and analgesic effects.
Paracetamol blocks COX in the central nervous system, affecting the centers of pain and thermoregulation (in inflamed tissues, cellular peroxidases neutralize the effect of paracetamol on COX), which explains the almost complete absence of anti-inflammatory effect. The lack of influence on the synthesis of prostaglandins in peripheral tissues determines the absence of a negative effect on water-salt metabolism (sodium and water retention) and the gastrointestinal mucosa.
Caffeine stimulates the psychomotor centers of the brain, has an analeptic effect, enhances the effect of analgesics, eliminates drowsiness and fatigue, and increases physical and mental performance.
Pharmacokinetics
Paracetamol is quickly and almost completely absorbed from the gastrointestinal tract, distribution in body fluids is relatively even. The binding of paracetamol to plasma proteins is minimal at therapeutic concentrations.
Paracetamol is metabolized in the liver and excreted in the urine in the form of glucuronide and sulfate metabolites - less than 5% is excreted unchanged. T1/2 when taking a therapeutic dose is 2-3 hours.
Caffeine is quickly absorbed from the gastrointestinal tract and distributed throughout the body. Caffeine is almost completely metabolized in the liver through oxidation and demethylation into metabolites that are excreted in the urine. T1/2 is 4-9 hours.
Indications for use Solpadeine fast pain reliever, tablets, 12 pcs.
- headache;
- migraine;
- toothache;
- lower back pain;
- neuralgia;
- muscle and rheumatic pain;
- painful menstruation;
- sore throat;
- symptomatic treatment of colds and flu (to reduce elevated body temperature).
Contraindications
- severe liver dysfunction;
- severe renal dysfunction;
- arterial hypertension;
- glaucoma;
- sleep disorders;
- epilepsy;
- children under 12 years of age;
- hypersensitivity to the components of the drug.
The drug should be used with caution in cases of benign hyperbilirubinemia (including Gilbert's syndrome), viral hepatitis, alcoholic liver damage, glucose-6-phosphate dehydrogenase deficiency, and alcoholism.
Effect on the body
Analgesic-antipyretic
Application Solpadeine fast pain reliever, tablets, 12 pcs. during pregnancy and breastfeeding
Solpadeine Fast contains caffeine. When taking caffeine, there is a high risk of having a low birth weight baby and a risk of spontaneous abortion.
When caffeine passes into breast milk, it can have a stimulating effect on a breastfed baby.
Solpadeine Fast should not be used during pregnancy and lactation (breastfeeding).
special instructions
Contraindication: severe liver dysfunction.
Contraindication: severe renal dysfunction.
Contraindication: children under 12 years of age.
Application is possible according to the dosage regimen.
Overdose
Symptoms caused by paracetamol: pale skin, nausea, vomiting, anorexia, stomach pain are possible within 24 hours; after 1-2 days, signs of liver damage may appear (pain in the liver area, increased activity of liver enzymes). There may be disturbances in carbohydrate metabolism and signs of metabolic acidosis. In adult patients, liver damage develops after taking more than 10 g of paracetamol. If there are factors that influence the toxicity of paracetamol to the liver, liver damage is possible after taking paracetamol in an amount of 5 g or more. In severe cases of overdose, encephalopathy, bleeding, hypoglycemia, cerebral edema, and even death may develop. It is possible to develop acute renal failure with acute tubular necrosis, the characteristic signs of which are pain in the lumbar region, hematuria, proteinuria, while severe liver damage may be absent. There are reports of cases of heart rhythm disturbances and pancreatitis.
Treatment: if an overdose is suspected, even in the absence of pronounced first symptoms, it is necessary to stop using the drug and immediately seek medical help. Within 1 hour after an overdose, it is recommended to lavage the stomach and take enterosorbents (activated carbon, polyphepan). The concentration of paracetamol in the blood plasma should be determined, but not earlier than 4 hours after the overdose (earlier results are unreliable). Administration of acetylcysteine within 24 hours after an overdose. The maximum protective effect is ensured during the first 8 hours after an overdose; over time, the effectiveness of the antidote drops sharply. If necessary, acetylcysteine is administered intravenously. In the absence of vomiting, methionine can be used before the patient is admitted to the hospital. The need for additional therapeutic measures (further administration of methionine, intravenous administration of acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as the time elapsed after its administration. Treatment of patients with severe liver dysfunction 24 hours after taking paracetamol should be carried out in conjunction with specialists from a poison control center or specialized liver disease department.
Symptoms caused by caffeine: epigastric pain, vomiting, frequent urination, tachycardia, arrhythmia, stimulation of the central nervous system (insomnia, restlessness, agitation, anxiety, increased neuro-reflex excitability, tremor and convulsions). It should, however, be taken into account that the appearance of clinically significant symptoms of caffeine overdose when taking this drug is always associated with severe liver damage due to an overdose of paracetamol.
Treatment: there is no specific antidote. Treatment includes supportive measures, such as drinking plenty of fluids and maintaining vital signs. Within 1 hour to 4 hours after an overdose, it is recommended to take activated carbon. To reduce the effects of caffeine overdose on central nervous system function, intravenous sedatives are recommended.
Side effects Solpadeine fast pain reliever, tablets, 12 pcs.
At recommended doses, the drug is usually well tolerated.
Determination of the frequency of side effects: very often (≥1/10), often (≥1/100 and
The following side effects were detected spontaneously during post-registration use of the drug.
Paracetamol
- Allergic reactions: very rarely - skin rash, angioedema (Quincke's edema), Stevens-Johnson syndrome, anaphylaxis.
- From the hematopoietic system: very rarely - leukopenia, thrombocytopenia, methemoglobinemia, agranulocytosis, hemolytic anemia.
- From the respiratory system: very rarely - bronchospasm (in patients with hypersensitivity to acetylsalicylic acid and NSAIDs).
- From the hepatobiliary system: very rarely - liver dysfunction.
With long-term use in high doses, the likelihood of hepatotoxicity, nephrotoxicity and pancytopenia increases. Also, in cases of long-term use in high doses, monitoring of the blood picture is necessary.
Caffeine
- Possible: dyspeptic symptoms (including nausea, epigastric pain), increased excitability, dizziness, sleep disturbances, tachycardia.
Excessive consumption of caffeine-containing foods (including tea, coffee) while taking the drug may cause restlessness, anxiety, irritability, insomnia, headache, disorders of the digestive system, tachycardia, cardiac arrhythmia.
If any of the listed side effects occur, you should stop taking the drug and consult a doctor immediately.
Drug interactions
When taken regularly over a long period of time, the drug enhances the effect of indirect anticoagulants (warfarin and other coumarins), which increases the risk of bleeding. Occasional administration of a single dose of the drug does not have a significant effect on the effect of indirect anticoagulants.
The drug enhances the effect of MAO inhibitors.
Barbiturates, carbamazepine, phenytoin, primidone, ethanol, rifampicin, phenylbutazone, St. John's wort, tricyclic antidepressants and other inducers of microsomal oxidation increase the production of hydroxylated active metabolites, causing the possibility of developing severe liver damage with small overdoses of paracetamol (5 g or more).
Microsomal oxidation inhibitors (cimetidine) reduce the risk of hepatotoxicity.
Under the influence of paracetamol, the elimination time of chloramphenicol increases 5 times.
Caffeine accelerates the absorption of ergotamine.
The simultaneous use of paracetamol and alcoholic beverages increases the risk of developing hepatotoxic effects and acute pancreatitis.
Metoclopramide and domperidone increase, and cholestyramine reduces the rate of absorption of paracetamol.
The drug may reduce the effectiveness of uricosuric drugs.
Overdose
In case of overdose (even if you feel well), you should immediately consult a doctor.
Signs of overdose: stomach pain, vomiting, nausea, pale skin, anorexia. After 2 days, symptoms of deterioration in liver function are revealed. hepatic coma is possible .
Treatment of overdose: use of enterosorbents , gastric lavage, symptomatic therapy.
SOLPADEIN FAST
Overdose
Symptoms (due to paracetamol)
An overdose of paracetamol may cause liver failure, which may lead to the need for a liver transplant or death.
The hepatotoxic effect in adults occurs when taking paracetamol in amounts of 10 g or more. If there are factors that influence the toxicity of paracetamol to the liver (see sections “Interaction with other drugs”, “Special instructions”), liver damage may occur after taking paracetamol in an amount of 5 g or more.
With long-term use of the drug in excess of the recommended dose, the drug may have a nephrotoxic effect (renal colic, nonspecific bacteriuria, interstitial nephritis, papillary necrosis).
During the first 24 hours after an overdose, the following symptoms may appear: nausea, vomiting, stomach pain, pale skin, anorexia, metabolic acidosis. After 1-2 days, signs of liver damage are determined (pain in the liver area, increased activity of “liver” enzymes), and possible development of carbohydrate metabolism disorders and metabolic acidosis.
In severe cases of overdose, encephalopathy (impaired brain function), bleeding, hypoglycemia, cerebral edema, even death, the need for liver transplantation, and death may develop as a result of liver failure. It is also possible to develop acute renal failure with acute tubular necrosis, the characteristic signs of which are pain in the lumbar region, hematuria (admixture of blood or red blood cells in the urine), proteinuria (increased protein in the urine), while severe liver damage may be absent. There have been cases of heart rhythm disturbances and pancreatitis.
Treatment
In case of suspected overdose with Solpadeine Fast, even in the absence of pronounced first symptoms,
You must stop using the drug and immediately consult a doctor for medical assistance. During the first hour after an overdose, but no later than 4 hours, it is recommended to lavage the stomach and take enterosorbents (activated carbon, polyphepane). The concentration of paracetamol in the blood plasma should be determined, but not earlier than 4 hours after the overdose (earlier results are unreliable).
Administration of acetylcysteine within 24 hours after an overdose. The maximum protective effect is ensured during the first 8 hours after an overdose; over time, the effectiveness of the antidote drops sharply. If necessary, acetylcysteine is administered intravenously. In the absence of vomiting, methionine can be used before the patient is admitted to the hospital. The need for additional therapeutic measures (methionine intake, intravenous acetylcysteine) is determined depending on the concentration of paracetamol in the blood plasma, as well as the time elapsed after its administration. Treatment of patients with severe liver dysfunction 24 hours after taking paracetamol should be carried out in conjunction with specialists from a poison control center or specialized liver disease department.
Symptoms (caused by caffeine)
Epigastric pain, vomiting, frequent urination, tachycardia, arrhythmia, stimulation of the central nervous system (insomnia, restlessness, agitation, anxiety, increased neuro-reflex excitability, tremor and convulsions). It should be borne in mind that the appearance of clinically significant symptoms of caffeine overdose when taking the drug is always associated with severe liver damage due to an overdose of paracetamol.
Treatment
There is no specific antidote. Treatment includes supportive measures, such as drinking plenty of fluids and maintaining vital signs. Within 1 hour to 4 hours after an overdose, it is recommended to take activated carbon. To reduce the effects of caffeine on CNS function, intravenous sedatives and beta-adrenergic antagonists are recommended to reduce the cardiotoxic effect.
Interaction
Barbiturates, Salicylamide , Rifampicin , antiepileptic drugs and other activators of microsomal oxidation accelerate the production of toxic paracetamol , which negatively affect liver function.
The half-life of Chloramphenicol under the influence of paracetamol is extended by approximately 5 times.
Metoclopramide accelerates the adsorption of paracetamol .
With repeated use, paracetamol can enhance the effects of indirect anticoagulants , which increases the risk of bleeding.
Caffeine accelerates the absorption of Ergotamine .
Blockers of microsomal oxidation reduce the risk of hepatotoxic effects of the drug.
Taking nervous system depressants (including alcohol) with codeine may enhance their effects.
special instructions
It is recommended to take Solpadeine with caution in case of liver or kidney diseases, intestinal disorders, after cholecystectomy , when taking antiemetics, drugs that cause drowsiness, indirect anticoagulants, monoamine oxidase inhibitors, ethanol together.
Solpadeine should not be used together with other drugs including paracetamol or codeine .
With prolonged use in dosages significantly higher than those indicated, periodic monitoring of the blood condition is necessary.
During treatment with the drug, excessive intake of coffee and tea is not recommended, because this can lead to tachycardia , sleep disturbance, agitation and even arrhythmia .
The patient should be warned that if side effects from digestion, allergic reactions , skin rashes, ulceration on the oral mucosa, bleeding and bruises , it is necessary to stop taking Solpadeine and immediately consult a doctor.
With long-term uncontrolled use of the described drug in large dosages, addiction (decreased analgesic effect) and dependence may occur.
During drug therapy, it is recommended to be careful when driving.
Side effects
The drug can extremely rarely cause:
- allergic reactions,
- nausea and vomiting, epigastric pain and heartburn,
- tachycardia and arrhythmia, increased blood pressure,
- hypoglycemia,
- disruptions in the functioning of the nervous system, which are complicated by dizziness, anxiety and insomnia,
- dysfunctions of the hematopoietic and lymphatic systems, which are accompanied by anemia,
- increased activity of liver enzymes.
Analogs
Level 4 ATC code matches:
Phenacetin
Combiflu
Chlorphenamine
Coldflu
Calpol
Fervex
Panadol Extra
Panadol for children
Panadol
Efferalgan
Milistan
Coldrex Maxgripp
Coldrex Hotrem
Coldrex
AntiGrippin
Unispaz
Pentalgin Plus
Rapidol
Maxicold
Perfalgan
Kaffetin , Aurora Hot Sip , Adzhicold, Gripout , Pentalgin , Ibuprofen , Mig 400 .
Price, where to buy
The price of Solpadeine in capsules No. 12 in Russia is on average 150 rubles, and in Ukraine it can reach 39 hryvnia.
The price of Solpadein Fast No. 12 in Russia is 130-150 rubles, in Ukraine – 30-41 hryvnia.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
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