Release form
250 mg capsules are available:
- 15 pieces in blisters; 4 such blisters in a cardboard package;
- 10 pieces in blisters; 3 such blisters in a cardboard package;
- 30 pieces in a polypropylene bottle; one such bottle in a cardboard package;
- 100 pieces in a polypropylene bottle; one such bottle in a cardboard package.
Structum 500 mg is available in 12 capsules in blisters; 5 such blisters in a cardboard package.
Tablets as a release form are not used in the production of the drug.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Chondroitin sulfate is one of the main components of cartilage and bone tissue, joints, it helps maintain the integrity of cartilage due to:
- enhancing the anabolic effect of chondrocytes (activation of proteoglycan );
- inhibition of the harmful effects of interleukin-1β on the structural components of cartilage;
- inhibition of excessive degradation of cartilage (by blocking elastase in tissues, reducing the activity of metalloproteases and increasing the activity of a metalloprotease ).
Chondroitin sulfate improves the balance of the synovial environment by increasing the production of hyaluronic acid - thus maintaining the proper viscosity and density of the synovial fluid. Chondroitin sulfate also suppresses the development of inflammatory reactions.
Pharmacokinetics
After taking the drug, more than 70 percent of it is absorbed in the digestive tract. The maximum concentration in blood plasma is observed after 3-4 hours, in synovial fluid - after 4-5 hours. Bioavailability is about 13%.
Structum 500 mg 60 pcs. capsules
pharmachologic effect
Tissue repair stimulator.
Composition and release form Structum 500 mg 60 pcs. capsules
Capsules - 1 capsule:
- Active substance: chondroitin sulfate sodium - 500 mg;
- Excipient: talc - 10 mg;
- Composition of the capsule shell (body and cap): indigo carmine, titanium dioxide, gelatin.
12 capsules in a blister made of PVC and aluminum foil, 5 blisters along with instructions for use in a cardboard pack.
20 capsules in a blister made of PVC and aluminum foil; 3,4, 5, 6, 7 or 10 blisters along with instructions for use in a cardboard pack.
Description of the dosage form
Gelatin capsules No. 0 from light blue to light blue.
The contents of the capsules are a whitish-cream powder; the presence of conglomerates (lumps) associated with the peculiarities of the spatial structure is allowed.
Directions for use and doses
Inside, with water. Adults and adolescents over 15 years of age are prescribed 1 g per day - 2 capsules of 250 mg or 1 capsule of 500 mg 2 times a day. The recommended duration of the initial course of treatment is 6 months, the period of action of the drug after its discontinuation is 3-5 months, depending on the location and stage of the disease, the duration of repeated courses of treatment is determined by the doctor.
Pharmacodynamics
Affects metabolic processes in hyaline and fibrous cartilage, reduces degenerative changes in the cartilage tissue of joints, stimulates the biosynthesis of glycosaminoglycans. Slows down bone resorption and reduces calcium loss, accelerates bone tissue restoration processes. When treated with Structum, pain decreases and mobility of the affected joints improves. The therapeutic effect persists for a long time after the end of the course of treatment.
Pharmacokinetics
More than 70% of chondroitin sulfate is absorbed in the digestive tract. The bioavailability of the drug is 13%. With a single oral administration of an average therapeutic dose, the maximum concentration in plasma is observed after 3-4 hours, in the synovial fluid after 4-5 hours. The drug absorbed in the gastrointestinal tract accumulates in the synovial fluid. Excreted by the kidneys.
Indications for use Structum 500 mg 60 pcs. capsules
Osteoarthrosis, intervertebral osteochondrosis.
Contraindications
Hypersensitivity to the components of the drug.
Children under 15 years of age (due to lack of accurate data).
Application of Structum 500 mg 60 pcs. capsules during pregnancy and breastfeeding
Structum is not recommended for use during pregnancy and lactation due to the lack of sufficient clinical data.
special instructions
Caution should be used in patients with bleeding, as well as in patients with a tendency to bleeding.
Overdose
In rare cases, symptoms of overdose from the gastrointestinal tract may occur: nausea, vomiting, diarrhea; with prolonged use of excessively high doses (over 3 g per day), hemorrhagic rashes are possible. Treatment is symptomatic.
Side effects Structum 500 mg 60 pcs. capsules
Rarely: allergic reactions (urticaria, erythema, itching); nausea, vomiting.
Drug interactions
With the simultaneous use of Structum with other drugs, it is possible to enhance the effect of indirect anticoagulants, antiplatelet agents, and fibrinelytics.
Instructions for use of Structum
Instructions for use of Structum 500 mg recommend taking the drug orally with water.
For adults and children over 15 years of age, the medicine is prescribed at a dose of 1 gram per day or 500 mg 2 times a day - that’s two capsules; it’s a mistake to say “tablets”. The optimal duration of the initial course of therapy is six months. The therapeutic effect of the drug lasts for 3-5 months, depending on the stage of the disease and its location. If necessary, repeated courses of treatment are allowed.
Structum 500 mg No. 60 caps.
Instructions for use of the drug for specialists Struktum ® Trade name Struktum ® International nonproprietary name Chondroitin sulfate sodium Dosage form Capsules 250 mg and 500 mg Composition One capsule contains the active substance - chondroitin sulfate sodium 250 mg and 500 mg, excipients: talc, gelatin, titanium dioxide , indigotine. Description Blue gelatin capsules, odorless. Pharmacotherapeutic group Other drugs for the treatment of diseases of the musculoskeletal system. ATC code M09AX02 Pharmacological properties Pharmacokinetics After oral administration, chondroitin sulfate is rapidly absorbed from the gastrointestinal tract. The maximum concentration in the blood plasma is achieved depending on the initial content of chondroitin sulfate in the blood, on average 3-4 hours after taking the drug. The bioavailability of chondroitin sulfate is 13%. The accumulation of chondroitin sulfate occurs mainly in the synovial fluid of the joints. Excretion is carried out mainly by the kidneys within 24 hours. Pharmacodynamics Structum affects metabolic processes in hyaline cartilage, reduces degenerative changes in the cartilage tissue of joints, and stimulates the biosynthesis of glycosaminoglycans. Structum has a prolonged effect and reduces the number of exacerbations of osteoarthritis. It has an analgesic and anti-inflammatory effect, reduces pain at rest and when walking. When treated with Structum, pain decreases, mobility of the affected joints improves, and the need for non-steroidal anti-inflammatory drugs decreases. Indications for use: degenerative diseases of the joints and spine: osteoarthritis, intervertebral osteochondrosis. Directions for use and dosage: Structum is taken orally with water. Adults are prescribed 1000 mg per day - 2 capsules of 250 mg or 1 capsule of 500 mg 2 times a day. The recommended duration of the initial course of treatment is 6 months, the aftereffect period of the drug after its discontinuation is 3-5 months, depending on the location and stage of the disease, the duration of repeated courses of treatment is set individually and depends on the location and degree of arthrosis and osteochondrosis. Side effects - allergic reactions - nausea, epigastric pain, flatulence, diarrhea, constipation. Contraindications - individual intolerance to the drug - tendency to bleeding, thrombophlebitis - phenylketonuria - pregnancy and lactation - children under 12 years of age. Drug interactions When Structum is used simultaneously with other drugs, it is possible to enhance the effect of indirect anticoagulants, antiplatelet agents, and fibrinolytics. Special instructions Features of the effect on the ability to drive transport and potentially dangerous mechanisms The use of the drug does not affect the ability to drive transport and potentially dangerous mechanisms. Use with caution in patients with a tendency to bleeding. Overdose Symptoms: increased side effects. Treatment: gastric lavage, symptomatic therapy. Release form and packaging Capsules 250 mg are packed in blisters of 15 pcs.; in a cardboard box there are 4 blisters (60 capsules) with instructions for use. Capsules of 500 mg are packaged in blisters of 12 pieces; in a cardboard pack there are 5 blisters, or 15 pcs., in a cardboard pack there are 4 blisters, or 20 pcs.; in a cardboard box there are 3 blisters (60 capsules) with instructions for use. Storage conditions Store at a temperature not exceeding 250 C. Keep out of the reach of children! Shelf life 3 years - capsules of 250 mg, 500 mg. Do not use the drug after the expiration date. Conditions for dispensing from pharmacies By prescription, France Progifarm, 45500 Zhien.
Analogues of Structum
Level 4 ATX code matches:
Nimulid
Diacerein
Aponil
Chondroitin sulfate
Sigan
Don
Nimegesic
Artiflex
Nimesil
Nimika
Artron Hondrex
Artron Flex
Artron Complex
Arthroker
Arthrodarin
Nemulex
Chondroitin
Glucosamine Hydrochloride
Glucosamine
Nimid Forte
The most common analogues of Structum are: Artron Chondrex , Chondroxide , Chondroflex , Teraflex , Alflutop . The price of analogues is an order of magnitude lower than the price of the original.
Reviews about Structum
Reviews of Structum are not fundamentally different from reviews of other drugs of identical composition. Forums containing reviews of patients about Structum say that chondroitin are most effective as part of complex treatment, including procedures that increase blood circulation and therapeutic exercises. Reviews from doctors indicate that injectable drugs are more effective than other forms of release (tablets and capsules).
Which is better: Artra or Structum?
Based on a comparison of the compositions of the drugs, we can conclude that the effect of Artra is more complex, since it additionally contains glucosamine, which protects cartilage tissue from various damages. Otherwise, it is worth remembering that injectable drugs have greater bioavailability, and the treatment of joint pathology must be multicomponent.
Structum price
The price of Structum (60 capsules of 500 mg) in Russia varies from 980 to 1370 rubles.
The price of Structum tablets in Ukraine averages 840 hryvnia and is even more variable depending on the region. Thus, buying the drug in the city of Kharkov will cost from 513 to 940 hryvnia. Injections of similar composition and action, as a rule, can be purchased below the price of Structum.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Structum capsules 500 mg 60 pcs. Pierre Fabre Medicament Production
RUR 1,696 order
Pharmacy Dialogue
- Structum (caps. 500 mg No. 60)Pierre Fabre Medicament
RUB 1,627 order
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Pharmacy24
- Structum 500 mg N60 capsules Pierre Fabre Medicine Production, France
900 UAH.order
PaniPharmacy
- Structum capsule Structum caps. 500 mg No. 60 France, Pierre Fabre Medicament Production
1023 UAH. order
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Structum capsules 500 mg No. 20x3
Name
Structum caps 500 mg in blister pack No. 12x5
Main active ingredient
Chondroitin sulfate
Release form
capsules
Compound
Active ingredient: Chondroitin sulfate sodium 500.00 mg Excipients: Talc 10.00 mg Composition of the capsule shell (body and cap): Gelatin, qs up to 112 mg (qs 100%) Titanium dioxide (E171). about 2.24 mg (2% ) Indigotine (E132). about 0.1014 mg (0.0905%)
Description
Capsule size 0+, opaque, blue, containing a conglomerated powder ranging in color from white to yellowish. 60 capsules in thermoformable blisters made of PVC-PVDC/aluminum foil coated with a layer of heat-sealable varnish. Each blister contains 20 capsules. Accordingly, 3 blisters are packed together with an insert in a cardboard box.
Dosage
500mg
Pharmacological properties
A drug for the treatment of osteoarthritis. Chondroitin sulfuric acid is an integral component of the ground substance of bone and cartilage.
Indications for use
Symptomatic treatment with delayed action of osteoarthritis of the hip and knee joints.
Contraindications
Hypersensitivity to the active substance or any of the excipients listed in section 6.1. Children under 15 years of age (due to lack of exact data).
Use during pregnancy and lactation
Data on the use of Chondroitin sulfate in pregnant women are absent or limited (less than 300 cases of pregnancy). Animal studies have not shown direct or indirect adverse effects regarding reproductive toxicity. As a precaution, it is recommended to avoid the use of the drug during pregnancy. Lactation It is not known whether Chondroitin sulfate and drug metabolites are excreted into breast milk. A risk to newborns and infants cannot be excluded. The drug should not be taken during breastfeeding. Fertility Animal studies do not show any effects on fertility.
Directions for use and doses
The drug should only be used in adults (over 15 years of age). Capsules are taken orally. Capsules should be swallowed whole with a large glass of water. One capsule 500 mg twice a day, i.e. 1 g per day. Use in children: There are no data allowing the use of chondroitin sulfate in children 0-18 years of age. Therefore, the use of chondroitin sulfate in children is not recommended.
Side effect
The table below summarizes the adverse effects observed in seven clinical studies involving a total of 2,244 patients, 1,154 of whom received STRUCTUM. Adverse effects are presented in accordance with the MedDRA system-organ classification and are listed below as: very often (? 1/10), often (? 1/100 to
Overdose
In case of overdose, symptomatic treatment is prescribed.
Storage conditions
Store at a temperature not exceeding 25°C, out of the reach of children.
Buy Structum caps 500 mg in blister pack No. 20x3 in the pharmacy
Price for Structum caps 500 mg in blister pack No. 20x3
Instructions for use for Structum caps 500 mg in blister pack No. 20x3
