Compound
The drug Ferlatum Fol contains the active substances: iron protein succinylate and calcium folinate pentahydrate .
As well as auxiliary components: sorbitol, sodium methyl parahydroxybenzoate, propylene glycol, sodium propyl parahydroxybenzoate, sodium saccharinate, cherry flavor, mannitol and purified water. Ferlatum also contains the protein iron succinylate . Auxiliary components: sorbitol, propylene glycol, sodium propyl parahydroxybenzoate, sodium saccharin, sodium methyl parahydroxybenzoate, flavoring and water.
Pharmacodynamics and pharmacokinetics
The drug Ferlatum Fol includes iron and calcium folinate . Therefore, when taking it, the lack of iron and folate in the human body is compensated.
The main function of iron in these preparations is to transport oxygen to tissues. This component is one of the components of hemoglobin, myoglobin and iron-containing enzymes-cytochromes . It also carries out electron transfer and functions as a catalyst for oxidation reactions, hydroxylation and other metabolic processes.
The active component, iron-protein succinylate , is a complex compound in which ferric iron atoms surround semi-synthetic protein carriers, which helps prevent damage to the mucous membranes of the gastrointestinal tract. The protein carrier can dissolve in the duodenum, optimally releasing iron.
The entry of ferric iron into the blood from the gastrointestinal tract occurs through active absorption, preventing the possibility of overdose or poisoning.
Ferlatum Fol solution for oral administration 15 mg fl PE 100 mg powder N10
Registration Certificate Holder
ITALFARMACO (Italy)
Dosage form
Medicine - Ferlatum FOL (Ferlatum FOL)
Description
Oral solution.
The solution for oral administration is transparent, brownish in color, with a pleasant characteristic cherry odor.
1 fl.
iron protein succinylate 800 mg, which corresponds to Fe3+ content 40 mg
Excipients
: sorbitol, propylene glycol, sodium methyl parahydroxybenzoate, sodium propyl parahydroxybenzoate, cherry flavor (concentrated wild black cherry flavor, vanillin, amyl acetate, small amounts of other esters, benzaldehyde, clove bud oil, propylene glycol, diethylene glycol monoethyl ether, water), sodium saccharinate, purified water .
Powder for the preparation of oral solution is white with a yellowish tint, odorless (in a sealed dispenser cap [container cap]).
100 mg
calcium folinate pentahydrate 235 mcg, which corresponds to the content of calcium folinate 200 mcg or equivalent to the content of folinic acid 185 mcg
Excipients
: mannitol.
15 ml - polyethylene bottles (10) with a container cap containing 100 mg of powder - cardboard packs. 15 ml - polyethylene bottles (20) with a container cap containing 100 mg of powder - cardboard packs.
Indications
- treatment of latent and clinically significant iron deficiency (iron deficiency anemia) and folate;
- prevention of iron and folate deficiency during pregnancy, lactation, active growth, after prolonged bleeding, against the background of inadequate and unbalanced nutrition.
Contraindications for use
- hemochromatosis;
- violation of iron utilization (including lead anemia, sideroachrestic anemia);
- non-iron deficiency anemia (including hemolytic anemia, megaloblastic anemia caused by a lack of vitamin B12);
- chronic pancreatitis;
- cirrhosis of the liver;
- hypersensitivity to the components of the drug.
Carefully _
the drug should be used for peptic ulcers of the stomach and duodenum, malabsorption in pathologies of the small intestine (including enteritis, malabsorption syndrome, resection of the small intestine, gastric resection according to Billroth II with the inclusion of the duodenum).
pharmachologic effect
Antianemic drug. Contains iron and calcium folinate. Replenishes the lack of iron and folate in the body.
The main function of iron is to transport oxygen to tissues. Iron is part of hemoglobin, myoglobin, iron-containing cytochrome enzymes, transfers electrons and works as a catalyst for oxidation reactions, hydroxylation and other metabolic processes.
Ferlatum Fol contains iron-protein succinylate, which is a complex compound where ferric iron atoms are surrounded by a semi-synthetic protein carrier that prevents damage to the gastric mucosa. The protein carrier dissolves in the duodenum, releasing iron at the site of optimal absorption.
Ferric iron enters the blood from the intestines through active absorption, which explains the impossibility of overdose and poisoning.
Calcium folinate is the calcium salt of folinic acid, which replenishes the lack of folate in the body.
Drug interactions
With simultaneous use, there was no interaction of the drug Ferlatum Fol with other drugs.
Iron absorption can be increased with simultaneous use of Ferlatum Fol with ascorbic acid in a dose of >200 mg.
Iron absorption may be reduced when Ferlatum Fol is used concomitantly with antacids.
Chloramphenicol causes a delayed response to iron therapy.
There is no pharmacological interaction with the simultaneous use of Forlatum Fol with histamine H2 receptor antagonists.
Some antitumor and antileukemic drugs (including aminopterin, methotrexate and other pterin derivatives) exhibit folate antagonist properties.
Dosage regimen
Ferlatum Fol should be taken orally before or after meals.
For adults
1-2 bottles/day in 2 doses (in an amount equivalent to 40-80 mg of ferric iron and 0.235-0.470 mg of calcium folinate pentahydrate) or as recommended by a doctor.
Children (from the neonatal period)
1.5 ml/kg/day (in an amount equivalent to 4 mg/kg/day ferric iron and 0.0235 mg/kg/day calcium folinate) in 2 divided doses or as recommended by a physician.
1 bottle (15 ml) contains: iron protein succinylate - 800 mg (equivalent to 40 mg ferric iron) and 0.235 mg calcium folinate pentahydrate (equivalent to 0.185 mg folinic acid).
Pregnant
for
the prevention of iron deficiency anemia
- 1 bottle/day.
For the treatment of latent or clinically pronounced iron deficiency
- 1-2 bottles/day in 2 divided doses.
After achieving normal levels of serum iron and hemoglobin, treatment is continued at a maintenance dose for at least 8-12 weeks.
Rules for preparing the solution
To prepare the solution for oral administration, press firmly on the perforator of the dispenser cap so that the powder pours into the solution in the bottle. Then you should vigorously shake the contents of the bottle, remove the dispenser cap and drink the solution from the bottle.
Overdose
To date, no signs of intoxication or excessive intake of the drug Ferlatum Fol into the body have been described.
Side effect
Rarely:
the appearance of gastrointestinal disorders that disappear when the dose is reduced or the drug is discontinued.
special instructions
The continuous period of use of the drug Ferlatum Fol should not exceed 6 months, with the exception of cases of chronic blood loss (including menorrhagia, hemorrhoids) and pregnancy.
Due to the possible development of allergic reactions, the drug should be prescribed with caution to patients with milk protein intolerance.
Ferlatum Fol contains sorbitol, so the drug should not be used in patients with hereditary fructose intolerance.
Effect on the ability to drive vehicles and operate machinery
The drug does not affect the performance of potentially hazardous activities that require increased concentration and speed of psychomotor reactions (including driving vehicles).
Storage conditions
The drug should be stored out of the reach of children at a temperature not exceeding 25°C.
Best before date
Shelf life: 2 years.
Use during pregnancy and breastfeeding
Restrictions during pregnancy - No restrictions. Restrictions when breastfeeding - No restrictions.
The use of Ferlatum Fol is especially recommended for the prevention and treatment of iron and folate deficiency that develops during pregnancy and breastfeeding.
Use for liver dysfunction
Restrictions for liver dysfunction - Contraindicated.
The use of the drug is contraindicated for liver cirrhosis.
Use in children
Restrictions for children - No restrictions.
Children (from the neonatal period)
1.5 ml/kg/day (in an amount equivalent to 4 mg/kg/day ferric iron and 0.0235 mg/kg/day calcium folinate) in 2 divided doses or as recommended by a physician.
Terms of sale
The drug is available with a prescription.
Contacts for inquiries
ITALFARMACO S.p.A. (Italy)
ITALFARMACO SpA
Representative office in Russia ITF LLC 115432 Moscow Andropov Avenue, 18, bldg. 6, off. 4-01 Tel. Fax
Contraindications for use
It is not recommended to take any iron supplement if:
- hypersensitivity;
- hemosiderosis;
- anemia caused by impaired iron utilization, for example, lead and sideroblastic, as well as non-iron deficiency - hemolytic and B12 deficiency;
- chronic pancreatitis;
- liver cirrhosis.
Instructions for Ferlatum (Method and dosage)
Iron preparations are intended for internal use before or after eating. The dosage is determined by the attending physician, taking into account the age, characteristics of the patient and the severity of the disorder.
When normal hemoglobin and serum iron are achieved, it is recommended to continue therapy at a maintenance dose for another 8-12 weeks.
Ferlatum is offered in a ready-to-use form. To prepare a solution for oral administration, using the instructions for Ferlatum Fol, it is necessary to press with some force on the perforator of the dispenser cap - this will allow the powder to pour out into the solution placed in the bottle. The contents of the bottle should be shaken vigorously, the dispenser cap should be removed and the resulting solution should be drunk.
Ferlatum Fol oral solution 15 ml N 10
Active substance
calcium folinate
ATX code
B03AB09 (Ferric proteinsuccinylate)
Release form, packaging and composition of the drug
Oral solution.
The solution for oral administration is transparent, brownish in color, with a pleasant characteristic cherry odor.
| 1 fl. | |
| iron protein succinylate | 800 mg, |
| which corresponds to the Fe3+ content | 40 mg |
[PRING] sorbitol, propylene glycol, sodium methyl parahydroxybenzoate, sodium propyl parahydroxybenzoate, cherry flavor (concentrated wild black cherry flavor, vanillin, amyl acetate, small amounts of other esters, benzaldehyde, clove bud oil, propylene glycol, diethylene glycol monoethyl ether, water), sodium saccharinate, purified water.
Powder for the preparation of oral solution is white with a yellowish tint, odorless (in a sealed dispenser cap [container cap]).
| 100 mg | |
| calcium folinate pentahydrate | 235 mcg, |
| which corresponds to the calcium folinate content | 200 mcg |
| or corresponds to folinic acid content | 185 mcg |
[PRING] mannitol.
15 ml - polyethylene bottles (10) with a container cap containing 100 mg of powder - cardboard packs. 15 ml - polyethylene bottles (20) with a container cap containing 100 mg of powder - cardboard packs.
Clinical and pharmacological group
Antianemic drug
Pharmacotherapeutic group
Hematopoiesis stimulator-iron drug
pharmachologic effect
Data on the pharmacokinetics of the drug are not provided.
Indications for use
- treatment of latent and clinically significant iron deficiency (iron deficiency anemia) and folate;
- prevention of iron and folate deficiency during pregnancy, lactation, active growth, after prolonged bleeding, against the background of inadequate and unbalanced nutrition.
Dosage
Ferlatum Fol should be taken orally before or after meals.
For adults
1-2 bottles/day in 2 doses (in an amount equivalent to 40-80 mg of ferric iron and 0.235-0.470 mg of calcium folinate pentahydrate) or as recommended by a doctor.
Children (from the neonatal period)
1.5 ml/kg/day (in an amount equivalent to 4 mg/kg/day ferric iron and 0.0235 mg/kg/day calcium folinate) in 2 divided doses or as recommended by a physician.
1 bottle (15 ml) contains: iron protein succinylate - 800 mg (equivalent to 40 mg ferric iron) and 0.235 mg calcium folinate pentahydrate (equivalent to 0.185 mg folinic acid).
Pregnant
for
the prevention of iron deficiency anemia
- 1 bottle/day.
For the treatment of latent or clinically pronounced iron deficiency
- 1-2 bottles/day in 2 divided doses.
After achieving normal levels of serum iron and hemoglobin, treatment is continued at a maintenance dose for at least 8-12 weeks.
Rules for preparing the solution
To prepare a solution for oral administration, press firmly on the perforator of the dispenser cap so that the powder pours into the solution in the bottle. Then you should vigorously shake the contents of the bottle, remove the dispenser cap and drink the solution from the bottle.
Contraindications
- hemochromatosis;
- violation of iron utilization (including lead anemia, sideroachrestic anemia);
- non-iron deficiency anemia (including hemolytic anemia, megaloblastic anemia caused by a lack of vitamin B12);
- chronic pancreatitis;
- cirrhosis of the liver;
- hypersensitivity to the components of the drug.
Carefully _
the drug should be used for peptic ulcers of the stomach and duodenum, malabsorption in pathologies of the small intestine (including enteritis, malabsorption syndrome, resection of the small intestine, gastric resection according to Billroth II with the inclusion of the duodenum).
Overdose
To date, no signs of intoxication or excessive intake of the drug Ferlatum Fol into the body have been described.
Side effects
Rarely:
the appearance of gastrointestinal disorders that disappear when the dose is reduced or the drug is discontinued.
Overdose
With simultaneous use, there was no interaction of the drug Ferlatum Fol with other drugs.
Iron absorption can be increased with simultaneous use of Ferlatum Fol with ascorbic acid in a dose of >200 mg.
Iron absorption may be reduced when Ferlatum Fol is used concomitantly with antacids.
Chloramphenicol causes a delayed response to iron therapy.
There is no pharmacological interaction with the simultaneous use of Forlatum Fol with histamine H2 receptor antagonists.
Some antitumor and antileukemic drugs (including aminopterin, methotrexate and other pterin derivatives) exhibit folate antagonist properties.
Storage conditions
The drug should be stored out of the reach of children at a temperature not exceeding 25°C. Shelf life: 2 years.
Conditions for dispensing from pharmacies
The drug is available with a prescription.
Special Instructions
The continuous period of use of the drug Ferlatum Fol should not exceed 6 months, with the exception of cases of chronic blood loss (including menorrhagia, hemorrhoids) and pregnancy.
Due to the possible development of allergic reactions, the drug should be prescribed with caution to patients with milk protein intolerance.
Ferlatum Fol contains sorbitol, so the drug should not be used in patients with hereditary fructose intolerance.
Impact on the ability to drive vehicles and operate machinery
The drug does not affect engagement in potentially hazardous activities that require increased concentration and speed of psychomotor reactions (including driving).
Overdose
Ferlatum Fol is well tolerated by patients and its use does not lead to overdose.
Cases of Ferlatum overdose are characterized by the development of epigastric pain , nausea, vomiting, diarrhea, drowsiness, pallor, shock and coma.
In this case, treatment is carried out using emetics, gastric lavage, and adequate supportive therapy.
Comparison of ease of use of Ferlatum and Ferlatum Fol
This includes dose selection taking into account various conditions and frequency of doses. At the same time, it is important not to forget about the release form of the drug; it is also important to take it into account when making an assessment.
The ease of use of Ferlatum is approximately the same as that of Ferlatum Fol. However, they are not convenient enough to use.
The drug ratings were compiled by experienced pharmacists who studied international research. The report is generated automatically.
Last update date: 2020-12-04 13:43:07
Interaction
The simultaneous use of iron-containing drugs with ascorbic acid can significantly increase the absorption of iron; antacids, on the contrary, reduce it.
Chloramphenicol may cause a delayed response to iron treatment.
Combination with certain antitumor and antileukemic drugs , for example, Aminopterin, Methotrexate and other pterin derivatives, can cause symptoms characteristic of folate antagonists. It is also possible that the absorption of tetracyclines in the gastrointestinal tract may be impaired.
Reviews about Ferlatum
It should be noted that iron-containing preparations are especially often discussed by parents of young children and women during pregnancy . This is not surprising, since it is during these periods that the body requires additional components and blood composition indicators are regularly monitored. Moreover, almost everyone who has used this drug leaves positive reviews about Ferlatum Fol. With its help, it is possible to quickly and reliably increase hemoglobin and normalize the general condition of the body.
Numerous reviews of pregnant women about Ferlatum report that this is one of the most effective remedies and put it in first place among similar drugs.
However, some women note that taking such drugs, on the contrary, worsens their well-being. This was manifested by the development of general ailments - fatigue, drowsiness, and external disorders - redness around the eyes, dulling of the complexion.
In any case, problems such as iron deficiency in the body or the development of suspected side effects should be addressed with your doctor. Timely prescribing or discontinuation of therapy will allow you to avoid complications and properly maintain your health.
Comparison of the effectiveness of Ferlatum and Ferlatum Fol
Ferlatum Fol is more effective than Ferlatum - this means that the ability of the medicinal substance to provide the maximum possible effect is different.
For example, if the therapeutic effect of Ferlatum Fol is more pronounced, then it is impossible to achieve this effect with Ferlatum even in large doses.
Also, the speed of therapy is an indicator of the speed of the therapeutic action; Ferlatum Fol and Ferlatum are also different, as is bioavailability - the amount of a medicinal substance reaching the place of its action in the body. The higher the bioavailability, the less it will be lost during absorption and use by the body.
Ferlatum during pregnancy
As a rule, iron supplements are often prescribed to pregnant women. Ferlatum Fol is usually used, since with the help of this remedy it is possible to compensate for the deficiency of iron and B vitamins, known as folates, which are involved in the production of red blood cells. A similar state of the body can be observed in young mothers.
In the majority, reviews during pregnancy are positive. The drug is characterized as quite effective and fast-acting, fully restoring hemoglobin . Moreover, the body absorbs this product better than other iron-containing products .
Comparison of addiction in Ferlatum and Ferlatum Fol
Like safety, addiction also involves many factors that must be considered when evaluating a drug.
So, the totality of the values of such parameters as “syndrome o” in Ferlatum is quite similar to the similar values in Ferlatum Fol. Withdrawal syndrome is a pathological condition that occurs after the cessation of intake of addictive or dependent substances into the body. And resistance is understood as initial immunity to a drug; in this it differs from addiction, when immunity to a drug develops over a certain period of time. The presence of resistance can only be stated if an attempt has been made to increase the dose of the drug to the maximum possible. At the same time, in Ferlatum the meaning of the “syndrome” is quite small, however, the same as in Ferlatum Fol.
Ferlatum price, where to buy
Price Ferlatum Fol in oral solution for 10 pcs. varies between 493-652 rubles.
You can buy Ferlatum for a price starting from 414 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Ferlatum solution for internal
approx. 800 mg 15 ml 20 pcs Italfarmako S.A. RUB 892 order - Ferlatum foul solution internal 15ml 10pcsItalfarmako S.A./Dobrolek LLC
625 rub. order
Pharmacy Dialogue
- Ferlatum Fol solution 15ml No. 10Italfarmaco
RUR 615 order
- Ferlatum solution 800 mg 15 ml No. 20Italfarmaco
880 rub. order
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