pharmachologic effect
Nootropic drug. It has a pronounced anti-amnesic effect, activates the integrative activity of the brain, promotes memory consolidation, improves concentration and mental activity, facilitates learning processes, accelerates the transfer of information between the hemispheres of the brain, increases the resistance of brain tissue to hypoxia and toxic effects, has an anticonvulsant effect and anxiolytic activity , regulates the processes of activation and inhibition of the central nervous system, improves mood.
Phenotropil® has a positive effect on metabolic processes and blood circulation in the brain, stimulates redox processes, increases the body's energy potential through glucose utilization, and improves regional blood flow in ischemic areas of the brain. Increases the content of norepinephrine, dopamine and serotonin in the brain.
Does not affect the level of GABA content, does not bind to GABAA and GABAB receptors, and does not have a noticeable effect on the spontaneous bioelectrical activity of the brain.
Phenotropil® has no effect on the respiratory and cardiovascular systems. Has a mild diuretic effect. It has anorexigenic activity when used as a course.
Phenotropil® has a moderate activating effect on motor reactions, increases physical performance, has pronounced antagonism against the cataleptic effect of neuroleptics, and reduces the severity of the hypnotic effect of ethanol and hexenal.
The psychostimulating effect of Phenotropil predominates in the ideational sphere. The moderate psychoactivating effect of the drug is combined with anxiolytic activity. Phenotropil® improves mood, has an analgesic effect, increasing the threshold of pain sensitivity.
Phenotropil® has an adaptogenic effect, increasing the body's resistance to stress under conditions of increased mental and physical stress, fatigue, hypokinesia and immobilization, and low temperatures.
With the use of Phenotropil, there is an improvement in vision (increased sharpness, brightness and fields of vision).
Phenotropil® improves blood supply to the lower extremities.
Phenotropil® stimulates the production of antibodies in response to the introduction of an antigen, which indicates its immunostimulating properties, but at the same time does not cause the development of immediate hypersensitivity reactions and does not change the allergic inflammatory reaction of the skin caused by the introduction of a foreign protein.
With a course of use of Phenotropil, drug dependence and tolerance do not develop. When discontinuing the drug, no withdrawal syndrome was observed.
The effect of Phenotropil appears after a single dose, which is important when using the drug in extreme conditions.
What should I take with it for the best effect?
As practice shows, the effect of even very effective drugs can be enhanced in combination with certain substances. In our case, it is recommended to take Phenotropil, Caffeine and Glycine at the same time for the best effect - of course, if there are no problems with the cardiovascular system.
This complex should be taken if you are afraid of not being able to cope with the assigned tasks, or if you need to receive a regular influx of energy over several weeks. It works like this:
- Phenotropil + caffeine stimulate the body in the morning.
- After lunch, you need an extra dose of caffeine to perk you up.
- Glycine is indicated to improve sleep, since insomnia is a side effect of the combination of Phenotropil and coffee.
Phenotropil can also be taken in conjunction with other medications to mutually enhance the effect - it all depends on the problem present.
Pharmacokinetics
Suction and distribution
After oral administration, it is quickly absorbed from the gastrointestinal tract, distributed in various organs and tissues, and easily penetrates the BBB. The absolute bioavailability of the drug when taken orally is 100%. Cmax in the blood is reached after 1 hour.
Metabolism and excretion
Phenylpiracetam is not metabolized in the body and is excreted unchanged. About 40% is excreted in urine, 60% in bile and sweat. T1/2 is 3-5 hours.
Pubmed
All information in the article is based on scientific medical materials.
PMID (from the English PubMed Identifier, PubMed ID) is a unique identification number assigned to each publication, description, abstract, or full text of which is stored in the PubMed database.
PubMed is an English-language text database of medical and biological publications created by the US National Center for Biotechnology Information (NCBI) based on the biotechnology section of the US National Library of Medicine (NLM). A key component of PubMed is MEDLINE. It was first introduced in January 1996. Available through NCBI-Entrez[en], a central search engine including PubMed, PubChem and other major medical databases. Contains approximately 25 million citations.
Indications for use of the drug
- diseases of the central nervous system of various origins, especially diseases of vascular origin or associated with metabolic disorders in the brain and intoxication (in particular, in post-traumatic conditions and phenomena of chronic cerebrovascular insufficiency), accompanied by a deterioration in intellectual and mnestic functions, a decrease in motor activity;
- neurotic conditions, manifested by lethargy, increased exhaustion, decreased psychomotor activity, impaired attention, memory impairment;
— violations of learning processes;
- depression of mild to moderate severity;
- psychoorganic syndromes, manifested by intellectual-mnestic disorders and apathetic-abulic symptoms, as well as flaccid apathetic states in schizophrenia;
- convulsive conditions;
— obesity (alimentary-constitutional origin);
— prevention of hypoxia, increasing resistance to stress;
— correction of the functional state of the body in extreme conditions of professional activity in order to prevent the development of fatigue and increase mental and physical performance;
— correction of daily biorhythm, regulation of the sleep-wake cycle;
— chronic alcoholism (in order to reduce symptoms of asthenia, depression, intellectual and mental disorders).
Comparison with other drugs
Of course, Phenotropil is not the only nootropic; there are other effective analogue drugs, but which is better? Let's make a short comparison of Phenotropil with such well-known drugs as Phezam and Mexidol.
Phenibut
Both products demonstrate a noticeable nootropic effect. Phenotropil acts as an antidepressant and stimulant, affects stress resistance, memory, and reduces obesity.
Phenibut has a complex effect on the nervous system; it can be prescribed to children over 3 years old and is recommended for use for migraines, low concentration, and depression. At the same time, Phenibut has fewer contraindications, so its scope of use is less limited. The composition contains aminophenylbutyric acid.
Mexidol
Phenotropil has a strong psychostimulating effect; it is effective for obesity, since it is able to stimulate metabolic processes, for convulsions, and depression. Mexidol is a preventive substance for oxygen starvation of brain cells and helps in its treatment; it is used for toxic intoxications and blockage of blood vessels.
Preference for one drug or another is given depending on the problem. So, if you need to eliminate oxygen starvation or improve blood circulation, take Mexidol, if you need brain stimulation and stabilization of the psychological state, use Phenotropil.
Dosage regimen
The dosage regimen is set individually.
Phenotropil® is taken orally immediately after meals.
The average single dose is 100-200 mg, the average daily dose is 200-300 mg. The maximum daily dose is 750 mg. It is recommended to divide the daily dose into 2 doses. A daily dose of up to 100 mg should be taken 1 time/day in the morning; a daily dose of more than 100 mg should be divided into 2 doses. The duration of treatment can vary from 2 weeks to 3 months. The average duration of treatment is 30 days. If necessary, the course can be repeated after a month.
To improve performance
Prescribe 100-200 mg 1 time/day in the morning for 2 weeks (for athletes - 3 days).
With nutritional-constitutional obesity
- 100-200 mg 1 time/day in the morning for 30-60 days.
It is not recommended to take Phenotropil® after 15 hours.
In sports
Due to its properties, Phenotropil is widely used in sports in combination with sports nutrition, although officially it is considered doping, and if the drug is detected in the blood of the violator, disqualification will occur. For athletes, its effect becomes noticeable already on the second or third day of use:
- physical activity increases;
- endurance increases;
- strength indicators increase.
Such properties are especially valuable for running and before training, although if we are talking about gaining muscle mass, Phenotropil will have to be abandoned - the drug is used for obesity, so taking it reduces appetite. The drug should not be taken immediately before the race, given the period of elimination of the substance from the body. It is recommended to take tablets 3-7 days before competitions at a daily rate of 200-500 mg.
Contraindications to the use of the drug
- hypersensitivity to the components of the drug.
Carefully _
the drug should be prescribed to patients with severe organic damage to the liver and kidneys, severe arterial hypertension, and severe atherosclerosis; patients who have previously suffered panic attacks, acute psychotic states, accompanied by psychomotor agitation (as there may be an exacerbation of anxiety, panic, hallucinations and delusions); patients prone to allergic reactions to nootropic drugs of the pyrrolidone group.
Alcohol compatibility
When taking the medicine, the need for alcohol noticeably decreases, the symptoms of withdrawal syndrome decrease, and the psychological mood improves. A single use of the drug eliminates the main signs of alcoholic delirium:
- Panic attacks.
- Aggressiveness.
- Visual hallucinations.
- Loss of orientation.
- Insomnia, nightmares at night.
As for compatibility, Phenotropil is often taken before drinking alcohol, preventing hangover and rapid intoxication. However, this practice is dangerous, since such use increases the toxic effects of alcohol, the amount drunk increases, and frequent simultaneous use of strong drinks and the drug leads to loss of vision, hearing and speech.
special instructions
It should be taken into account that with excessive psycho-emotional exhaustion against the background of chronic stress and fatigue, chronic insomnia, a single dose of Phenotropil on the first day can cause a sharp need for sleep. For such outpatient patients, it is recommended to start taking the drug on non-working days.
Use in pediatrics
Phenotropil® is not recommended for use in children due to the lack of clinical data on the use of the drug in children.
Experimental results
Phenotropil® is characterized by low toxicity; the lethal dose in an acute experiment is 800 mg/kg. Does not have a carcinogenic effect.
Termination of production of phenotropil
Many of you are faced with the impossibility of purchasing such an effective nootropic as Phenotropil in pharmacies. This is due to the cessation of its production by Valenta-Pharm due to patent disputes with the inventor, Valentina Akhapkina. Her plans were to expand the field of application of the drug and introduce new dosage forms (including injections), but the manufacturing company refused this. Phenotropil produced by Akhapkina’s own company (Vira Innfarm) is not yet available for purchase. The Baltic generic is also currently unavailable.
For weight loss
When no methods help to lose weight, including exercise and a balanced diet, women decide to opt for medical weight loss. The drugs include Phenotropil.
Since it has long been discontinued, many are starting to look for substitutes for weight loss. Among them it is worth highlighting such analogues as:
- "Pantogam";
- "Cerebrolysin";
- "Encephabol";
- "Neurodar".
All of the above analogues of phenotropil have properties that accelerate metabolic processes. Experts have found that these drugs eliminate all the symptoms that accompany the feeling of hunger, including:
- increased fatigue and irritability;
- loss of energy;
- significant decrease in performance.
Drug effect
Phenotropil has such a powerful effect on the body that patients often wonder whether this drug is a drug or not. Although included in the list of doping substances and partially exhibiting the effect of amphetamine, Phenotropil is nevertheless not a drug.
It has a psychostimulating effect on the body, reminiscent of a drug effect, enhancing the production of neurotransmitters - dopamine, norepinephrine and serotonin, while increasing productivity and improving the emotional component.
Reviews
Quite often, before deciding to use a particular product, people start looking for patient reviews. Phenotropil is no exception; there are a lot of opinions about it on the Internet, including reviews from people losing weight:
Sergey 03/01/2014:
I tried Phenotropil when I encountered a creative crisis. It helped. Literally from the first appointment, clarity of thought and frantic performance.
Irina 07/12/2016:
I unsuccessfully struggled with excess weight for four years until I tried Phenotropil. I can’t say that I lost an insane amount of kilograms, but I definitely lost weight, and I got rid of my excessive appetite.
Andrey 11/26/2019:
I accept when the session starts. Great for helping you concentrate.
What to replace it with?
Unfortunately, the nootropic drug Carphedon (phenotropil) has not been produced since 2017. As a result, the question arose among consumers about whether there was a replacement for it. This is due to the fact that many people who have been using this drug for a long period of time have already decided on the required dosage, course of treatment, and breaks. That is why it will be quite difficult for them to get used to another drug, which is a derivative of phenylpiracetam.
Among the analogues of Phenylpiracetam, the following should be highlighted:
- "Braviton" is available exclusively by prescription in the form of tablets. Helps improve blood circulation, reduce platelet aggregation, provide reliable brain protection during hypoxia;
- Vinpocetine improves memory and increases concentration. Indications for use include: traumatic brain injury, encephalopathy, senile dementia;
- "Escotropil" - produced on the basis of piracetam, is aimed at stimulating cognitive processes. The effect on the central nervous system is to change the speed of impulses to the brain, stimulating the metabolic process of nerve cells.
Such drugs belong to the group of psychostimulant drugs. By the way, many people are misled by such names as Phenylpiracetam, Carphedon. It is worth noting that these are just synonyms for modified piracetam.
The best
Sometimes there is a need to replace Phenotropil with a more effective option. Today, this is due to the fact that this drug is simply not available on the pharmacy window. Among the most powerful drugs that are analogues of phenotropil, it should be noted:
- "Cavinton";
- "Nootropil";
- "Lutsetam" and others.
It is worth noting that even the best analogue cannot completely replace the original medicine, since the main component can be supplemented with several additional substances.
Imported
Today, there are a large number of imported drugs that act as analogues of phenotropil. Among them are:
- "Piracetam";
- "Acefen";
- "Cogitum";
- "Vinpotropil";
- "Bravinton".
The above analogues have the same properties as the domestic drug called Phenotropil. The only disadvantage of medicines produced by a foreign manufacturer is the high cost of the drug.
