Products that stimulate regeneration Fermenkol (gel)

From this article you will learn:

• Fermenkol: patient reviews, price,
• Fermenkol gel - instructions for use using the application method and using the phonophoresis technique.

Fermenkol is a drug based on a complex of proteolytic enzymes (collagenolytic proteases) obtained from marine and freshwater organisms. Fermenkol destroys excessively formed pathological collagen, which makes up hypertrophic and keloid scars.

Indications for use –

• for hypertrophic and keloid scars (Fig. 1-2),
• for scars after acne (Fig. 3),
• to prevent the occurrence of these types of scars.

Release form and composition

Fermenkol is available in the following forms:

• gel: transparent, colorless mass (10 g and 30 g in aluminum tubes);
• lyophilized powder: light yellow or light brown mass (4 mg in glass bottles; included in the kit for enzyme correction together with Solactin, a clear liquid for preparing an enzyme solution).

Composition of 1 g gel:

• active ingredients: complex of collagenolytic proteases with molecular weights from 23 kDa to 36 kDa – 0.1 mg;
• auxiliary components: acrylate crosspolymer, ammonium sulfate, glycerin, methylisothiazolinone, water.

Fermenkol in the form of a lyophilized powder also contains a complex of collagenolytic proteases with molecular weights from 23 kDa to 36 kDa as an active component.

Solactin (solvent) contains the following components: potassium hydroxide, methylisothiazolinone, citric acid, calcium chloride, water.

Side effects

The use of the drug is almost always easily tolerated by patients; it extremely rarely causes side effects.

Possible adverse reactions include the following:

• allergic reactions;
• the appearance of itching, irritation and urticaria in the areas where the product is applied;
• local redness and increased skin temperature;
• a tingling feeling that disappears fairly quickly.

Any side effects when using Fermenkol are mild. They may disappear on their own during the treatment process as the skin adapts to the drug. If unwanted reactions do not disappear, it is recommended to choose another drug.

Pharmacological properties

Fermencol has a collagenolytic effect. It ensures deep hydrolysis of collagen, breaking peptide bonds between amino acids. The drug exhibits selective activity against pathological collagen molecules with vortex and nodular packing. It exhibits less activity against fibrils of native collagen present in healthy tissue. The destruction of excess collagen leads to scar reduction.

Fermencol also has a general proteolytic effect and is capable of hydrolyzing polysaccharides. Thanks to this, a complex effect is achieved on the components of scar tissue.

When Fermenkol is used to eliminate acne and its consequences, the scar capsule around the inflamed glands is destroyed, as a result of which they are cleansed, the volume of scar tissue is reduced and the skin is smoothed.

Thanks to the use of a cosmetic product, the following effects are observed:

• the volume of the scar decreases;
• the color of the skin in the scar area is normalized;
• itching and discomfort are reduced;
• the feeling of tightness is removed;
• The elasticity of the skin in the scar area increases.

How Fermenkol works -

The active components of Fermenkol have high activity in reducing the rate of collagen production in the skin. As you know, scar tissue forms due to increased levels of collagen production. Keloid and hypertrophic scars are formed as a result of an unexplained failure in collagen production - when collagen is produced in excessive, excessive quantities.

Collagenase, which is part of Fermenkol products, selectively acts only on the molecules of pathological collagen contained in the scar tissue of atrophic and keloid scars, destroying them, resulting in a reduction in the scar. According to the manufacturer: Fermenkol has virtually no effect on normal collagen of healthy skin tissue.

Thus, with the help of a complex of enzymes, collagen and elastin fibers are hydrolyzed, which break down into individual amino acids. Enzymes also hydrolyze polysaccharides in scar tissue, such as hyaluronic acid.

Important : Fermenkol only acts on scars that are no more than 1-2 years old, when scar tissue formation is still active.

Technologies that ensure the effectiveness of Fermenkol –

1. Firstly, the manufacturer uses collagenolytic proteases with a molecular weight of only 23,000 to 36,000 Daltons, which ensures good penetration of enzymes deep into scar tissue.
2. Secondly, Fermenkol contains components that increase the permeability of the stratum corneum of the skin by increasing its hydration (moistening), and also increase the permeability of the dermis due to the swelling and loosening of interstitial collagen and elastin.
3. It is also known that scar tissue has very little hydration (moistening) with water when compared to normal skin tissue. A normal level of hydration provides healthy skin with turgor, elasticity, a youthful and healthy appearance. Fermenkol provides not only the hydrolysis of pathological collagen, but also deep hydration of scar tissue, which together ensures a reduction in scars, as well as an improvement in their appearance.

Directions for use and dosage

Gel

Fermenkol in gel form is used in the form of applications, as well as during phonophoresis and electrophoresis procedures.

Applications with the gel are recommended in the early stages of scar formation (no earlier than 3–4 weeks after surgery, burn or injury).

The gel is applied to clean, dry skin in the scar area 2-3 times a day. The duration of one course is 30–40 days. A repeat course is possible after 10–14 days.

To correct dense mature scars after wounds, surgical interventions, acne, burns and Dupuytren's contracture, phonophoresis with Fermencol gel is used. With phonophoresis, the effect of the drug is enhanced, as a result of which the skin restoration process is accelerated.

Before the phonophoresis procedure, it is recommended to thoroughly clean the skin. To improve the penetration of the active components into the tissue, you can apply a hot cloth (not scalding).

When used in the neck and face area, the recommended radiation intensity is 0.2 W/cm2, in the area of ​​the limbs and torso – 0.3 W/cm2. When using phonophoresis in children, the duration of the procedure per area is 2–3 minutes, in adults – 3–5 minutes. The total duration of phonophoresis in several areas: for children – 10 minutes, for adults – 20 minutes. The procedures are carried out daily, the interval between them should not be more than 2 days. One course requires 10–15 procedures. Repeated courses are possible after 10–14 days.

The phonophoresis procedure is performed with extreme caution on young scars, since ultrasound can stimulate scar growth. In children, ultrasound therapy can be used from 3 years of age, but it is recommended to avoid exposure to ultrasound on growth areas.

If it is impossible to carry out phonophoresis, electrophoresis with Fermenkol is used. The procedure is carried out using the Nevoton apparatus.

Electrophoresis is used for scars of limited area located on the face, for example, for post-acne scars. The procedure is also indicated for the correction of scars in hard-to-reach areas (in the armpit area, on the hands).

Lyophilized powder

Fermencol in the form of a lyophilized powder is used during the electrophoresis procedure, having previously prepared a solution of the required concentration. When choosing the concentration of the solution, the area, depth, age and clinical shape of the scar are taken into account:

• hypertrophic scar up to 6 months: 0.01% solution (1 bottle of powder requires 40 ml of Solactin);
• hypertrophic mature scar: 0.02% solution (1 bottle of powder requires 20 ml of Solactin);
• keloid scar up to 6 months: 0.05% solution (1 bottle of powder requires 8 ml of Solactin);
• keloid mature scar: 0.1% solution (1 bottle of powder requires 4 ml of Solactin).

To carry out the electrophoresis procedure, about 0.1–0.2 ml of solution is required per 1 cm2 of scar tissue. Moisten a gauze pad or a layer of filtered paper with the prepared solution and apply it to clean, dry skin. A gasket with an electrode soaked in water should be placed on top. The gasket should be slightly larger than the electrode and protrude beyond its perimeter to avoid burns.

Introduction is carried out from the anode (positive pole). When the scar is localized in the neck and face, the current density should be no more than 0.05 mA/cm2, for scars on the skin of the limbs and torso - no more than 0.1 mA/cm2. When carrying out the procedure in children under 5 years of age, the current density during electrophoresis in the neck and face should be no more than 0.01 mA/cm2.

The duration of one procedure for children under 5 years old is 10–15 minutes, for adults and children over 5 years old – 20–25 minutes. The procedures are carried out daily, with a permissible interval of no more than 2 days. One course requires 10–15 procedures. Repeated courses are possible after 7–10 days.

Products that stimulate regeneration Fermenkol (gel)

Oh, what a problem girl I am. And I have bad hair (restored, TTT), and scars on my face, and excess weight) Just an excellent object for testing all kinds of miracle remedies: P So, another long review)

I tried this gel at the dawn of its appearance, in 2008, and it seriously helped smooth out the scars on my face (I have different ones - hyper-, atro- and normotrophic, but I am more concerned about the protruding hypertrophic ones). For those who remember, this was the time when Solazol spray was included in the gel/creams. And the gel helped me without any electrophoresis/phonophoresis and so on.

But my hands are playful, I am one of those funny people who find it difficult not to rip off a wound on their leg, not to squeeze out a pimple, and who are the source of their own scars. It would not be an exaggeration to say that I have a lot of scars, these are not just dots from squeezed out pimples, but I don’t do that anymore, almost ^^. And I don’t regret and love my terrible scars, but I don’t want to scare people, and I want more lovers, so I again needed Fermenkol for the existing new fresh (~1-2 years) scars. Especially hypertrophic ones, which Fermenkol should have handled with a bang.

I almost always bought fermenkol from their website (or from their resellers in my city). In 2011, fermenkol was not available for sale due to technical reasons. In 2012 it appeared, but the batch was defective, the gel caused skin irritation, which I found out by writing to them about it, they sent me another tube as a replacement, which did not cause irritation, but did not help at all :(.

Since 2012, the gel came without Solazol spray and before application it was only recommended to wipe the skin with some cleansing lotion or something like that. To be honest, I don’t like changes like this, and, apparently, they tinkered with the composition. Therefore, I thought that after a defective batch they added less than what was needed for each element, and the product stopped working.

I decided that I would wait a little, maybe the next batch will have the normal composition. I waited and bought a new tube of gel. To be sure, I bought a Nevoton device for electrophoresis at home. Conducted a course of procedures - 0 effect. Precisely 0, not a “weak effect”. In general, I didn’t like Nevoton, the instructions say “you should feel a pleasant tingling sensation” - fig. Either it gives you an electric shock, or you don’t feel anything. In short, nothing pleasant.

Oh, and by the way, I also tried Mepiform patches. Absolutely useless on the face - don't waste your money! Maybe they would somehow stay on the cheeks, but on the forehead/chin (especially if the skin is uneven, and of course it is uneven). And I’m generally silent about the possibility of using them repeatedly.

I started looking for other options. And here I can recommend 2 good, and even very good things (however, the story about fermenkol is not finished yet).

1) Hiruscar gel, produced in Hong Kong in collaboration with Switzerland (site where you can buy and read reviews, mainly in Chinese X) -> [link]).

There are two types of tubes: “3in1”, 10 g each. and “2in1” 20 gr. Both will cost ~423 rubles, when ordering 2 pieces. on promotion. Payment by card or via PayPal, in general there are different payment methods. Delivery is free only for orders over $39, otherwise delivery will cost $12 (~400r). It takes ~1 month. I advise you to take 2, it’s cheaper. I didn’t try the 10-gram one, I took the cheaper one, it seemed to me that they were the same in composition and purpose. Next time I’ll try “3in1”. But for testing, “2 in 1” is enough.

If you look at it, its composition/consistency/smell is similar to useless contratubes/mederma. Those. it contains one of the components Allium Cepa = onion. I saw this when ordering, but the reviews convinced me to try it. Actually, although it is similar, it is different, and its smell is gentler and more pleasant, and it is quickly absorbed like a real gel; you can apply foundation on it without any problems.

From this gel I got the effect that I expected from Fermenkol, i.e. visible : |!!! In fact, the scars did not smooth out at all, but they really began to look better and became lighter. There are products in the world about which you think “it seemed to help, but maybe it didn’t help” or “it seemed to help me, but it turned out that it was self-deception.” So with hiruscar it helped 100%, I’m glad I took it, and then I bought 2 more tubes as a reserve. I still have a suspicion that it makes my skin better; it has never (TTT) caused me any pimples or blemishes like other creams and gels.

It’s hard for me to say how long it lasts, because... I use it with short experimental breaks. It’s definitely enough for a month, maybe 2. I started using it in September. I'm finishing my second tube now.

2) Dermaroller/mesoroller (dermaroller/dermapen/dermastamp), 1.5mm (I'm thinking about trying 2mm for some areas, and using a dermapen instead of a dermaroller). The internet is full of pictures. There are needles of shorter length, but for scars the recommended length is from 1.5 mm for the face, 2 mm for the body. There are also rollers with different numbers of needles - 540 and 200. I recommend 200, I tried 540 - it penetrates the skin worse and takes a long time to heal.

Pros: everyone knows that we knock out a wedge with a wedge). In fact, if they hadn’t started selling such a thing, I would have come up with something like that myself. In general, physiotherapists abroad recommend massage to “break” scars. In this case, this is a more radical breaking, probably closer to a fraxel laser. The needles passing through the scar destroy some of its fibers, giving way to new skin. This is of course a very long process. But judging by the reviews, it has results, especially for post-acne (for example, this guy posted his results on a video blog for almost two years [link]). But I also noticed changes for the better in my scars, little by little the scars are leveling out. This is noticeable, especially after the first two procedures. If it weren’t so painful, I would do this procedure every extraction.. I’ll probably start doing every extraction, I’ll only finish the epic with Fermenkol).

This method has disadvantages:

it hurts, especially on the face X) It’s tolerable, but it hurts. Some people use painkillers, but I’m somehow afraid to apply extra medicine, I’d rather be patient. On the body, most likely, it is not so noticeable. It bleeds during the procedure, then the face is inflamed, it takes at least a couple of days to recover. It all depends on your glamor, I don’t worry about scars or redness on my face, so it’s not a problem for me to go to work, even if my face has not yet fully recovered.

I first ordered through a group on VK (~770 rubles), and then I started ordering through ebay ^^ (you need PayPal), they cost about $5 (~150 rubles) there with free shipping, it took me ~1.5 months. There is no difference in quality, it is bad everywhere)) joke). They are simply designed for one-time use, but if used carefully, they should be enough for ~6 times. However, this does not apply to long needles, IMHO. In general, I don’t know... After one time, the games can become dull, bend slightly, after which they begin to “catch” the skin, and the process becomes more painful.

So... I certainly liked these two pieces, but I was still hoping for something more). Therefore, having once again read all the materials on the Fermenkol website, I decided to try phonophoresis). I ordered a Reton device there for phonophoresis at home. Took the course (and even longer). No result. Zero. I can’t say anything bad about the device, it’s pleasant, it feels warm and all that, it might even work, so it’s normal. But the scars were and remain.

I gave it up for a while. Then I finally got inspired to try scrubs and peels (which I heard about that don’t help with scars, but you never know...). Scrub is, of course, pampering. But the peeling (exfoliant) from Cora is nothing like that, it does not remove scars, but it evens out the skin around it a little, so there is some effect. I don't regret the purchase. But I decided to kill two birds with one stone and try applying Fermenkol after peeling. They also advise applying it after cleansing the skin, and what could be cooler than peeling?! But I don't see any effect. Of course, I will finish the tube, but I won’t buy it again, and I won’t recommend it.

I know one thing, before the gel helped without any additional devices or procedures, but now it doesn’t help at all.

********

PS I can’t help but mention all sorts of radical measures, such as laser, dermabrasion, deep acid peels, etc. Baba Yaga is against) I advise you to read the reviews, especially the first link (especially page 11, as well as Olga’s reviews!!)

[link]

[link]

[link] (in English)

I can tell you from my personal experience. Somehow I decided to have mechanical dermabrasion, went to a cool paid clinic in my city, and made an appointment with a surgeon for a consultation (400 rubles). He looked, felt, and said - you can’t do it yet (it was summer), buy Dermatix (sucks! Jewishly expensive sticky sparkling thing that you can’t apply foundation on), come in the fall. I asked him about Fermenkol, that it gives good results and all that. This was the first time he had heard about this remedy). This is a doctor who deals with scars! The consultation lasted at most 7 minutes. Of course, I frowned, but I came in the fall. There was another cool doctor there (another 400 rubles). The consultation again took no more than 7 minutes. She told me, “how can I do dermabrasion for you here, I don’t even have a cutter like that, there’s only a laser, come tomorrow, we’ll do everything.” Omg.. no mention of the consequences, about pigmentation, about the rehabilitation period. Of course, I decided that no, no, especially in my city).

If anyone can recommend anything else, write: R. If I find anything else good, I’ll write in the comments ^^

Reviews about Fermenkol

On the Internet you can find numerous reviews about Fermenkol. In most cases, the cosmetic product is evaluated positively, noting its effectiveness, ease of use, natural composition, absence of dyes and fragrances, good tolerance and the rare occurrence of allergic reactions.

The disadvantages of the product include its high cost and short shelf life of opened packaging. Some patients note its low effectiveness and rapid consumption. Also in reviews you can find information that the drug is not sold in all pharmacies.

Features of use during pregnancy

Pregnancy is not a direct contraindication to the use of the drug. The product is intended for external use, so it is not dangerous to the health of mother and child.

It is worth considering that during pregnancy, skin reactions can be unpredictable. During this period, under the influence of hormones, she is most prone to various allergic reactions. It is also possible that the effectiveness of therapy will decrease. If any side effects occur, it is recommended to stop treatment immediately.

Cheap and expensive analogues

The drug has many analogues from different price categories.

Inexpensive substitutes include the following:

1. Dermofibrase.
2. Lidaza.
3. Vinitan Forte.
4. Kelotan.
5. Rescuer.
6. Contratubeks.

More expensive products include the following:

1. Kelo-Kot.
2. Strataderm cream.
3. Stratamed.
4. Collost.
5. Dermatix.

The drugs have a similar principle of action, but differ in their composition. The selection of a substitute is advisable in case of individual intolerance to the components and hypersensitivity to them.

If you have a tendency to allergic reactions, it is necessary to first check for allergies when using each product and begin therapy gradually.

Price of the drug in Moscow, St. Petersburg and regions

The cost of the product differs depending on the region of sale. Approximate prices will be presented in the table below.

The drug can also be purchased from online pharmacies. The average cost in this case is 850-950 rubles. The price is for Fermencol gel 10 mg. A volume of 30 mg costs on average 1500-1600 rubles.

Reviews from dermatologists about the effectiveness of the product

Experts note that Fermencol is several times more effective than many well-known drugs. Compared to products such as Contratubeks, Collagenase or Kelotan, Fermenkol provides the fastest results.

In severe cases, dermatologists and cosmetologists recommend using not only a gel for topical application, but also combining it with phonophoresis. This approach allows you to destroy the structure of a scar, scar, burn or stretch mark in the deep layers of the epidermis. That is why many experts compare the Fermenkol treatment course with laser correction techniques.

Unlike laser, Fermenkol has practically no contraindications, it is easily tolerated by patients, rarely provokes side effects and does not require a rehabilitation period.

To achieve the desired result, dermatologists recommend taking a course of therapy, which on average includes 20 phonophoresis procedures and regular application of gel to the affected areas for a month.

Not only doctors and cosmetologists note the high results from using the product. Most patients were also satisfied; reviews of this drug were mostly positive. People note a mild effect, quick results, as well as a general improvement in the condition of the skin.

Many experts note the high effectiveness of the use of Fermencol gel. To achieve maximum results, they recommend strictly following the instructions for use.

Author: Kolenova Victoria

Interactions

Fermenkol gel (instructions for use are presented for informational purposes only and do not replace the official instructions for the product) does not imply interaction with other medications.

In order to maintain the effectiveness of the product, it is not recommended to apply it to the skin immediately after other local medications. If you have a tendency to allergic reactions, it is recommended to first consult with a specialist if complex treatment is planned.

special instructions

Applying the drug to areas with violations of the integrity of the skin does not imply danger. If the gel or powder gets into your eyes, you must immediately rinse them with warm, clean water.

Fermenkol is allowed to be used locally after malignant neoplasms, but only with caution and after consulting an oncologist. During the treatment process, it is necessary to be regularly monitored by a specialist. It is not recommended to apply cosmetics immediately after using the drug; it is advisable to wait a while.

Terms of sale and storage

The drug must be stored in a dry and dark place, out of reach of children. The temperature should be from 0 to +25 degrees. An open tube of gel must not be stored for more than 1 month. The finished solution can be stored for a week if the temperature is maintained. Recommended temperature is from +1 to +6 degrees. The sealed period is 3 years.

The drug is freely available and does not require a prescription to purchase it.