Why should glycine be placed under the tongue?

What is glycine and what is its role in the body? Glycine is a non-essential amino acid that is involved in many vital processes and also helps to survive emergency situations. The key role of glycine is its direct participation in the process of energy formation in cells, protecting them from premature death and ensuring proper functioning. This is a unique substance with almost universal properties, which our body can produce on its own, but at the same time often experiences an increased need for it.

Composition/description

Registration number: LSR-001431/07
Trade name: Glycine

International nonproprietary name:

glycine.

Dosage form:

sublingual tablets.

Composition per tablet:

microencapsulated glycine (in terms of the active ingredient glycine - 100 mg), excipients: methylcellulose - 1 mg, magnesium stearate - 1 mg.

Description:

round flat-cylindrical tablets of white or almost white color with marbling elements with a chamfer and a score.

Transbuccally - how is that?

The characteristics of the glycine molecule determine the easiest way for it to penetrate into the blood - through the mucous membrane of the mouth.

In the instructions for use, you may find the words “sublingual” or “buccal”. What “sublingual” means can be understood simply by the sound of the word - the tablet must be placed under the tongue and kept there until completely dissolved, without dissolving.

Buccal administration is the placement of a tablet or powder behind the cheek, between the cheek and gum, usually in the area of ​​the angle of the lower jaw. Buccal administration is especially convenient for young children, children with developmental delays, neurological patients, during and after a stroke, when keeping the medicine under the tongue is problematic.

Pharmacological properties

Pharmacotherapeutic group:

metabolic agent.

ATX code:

N06BX.

Pharmacodynamics: Glycine is an amino acid and one of the main inhibitory neurotransmitters in the brain. Glycine normalizes and activates protective inhibition processes in the central nervous system, reduces psycho-emotional stress, and increases mental performance.

Glycine has glycine- and GABA-ergic, alpha1-adrenergic blocking effects, regulates the activity of glutamate (NMDA) receptors.

The drug has the following properties:

• – reduces psycho-emotional stress, aggressiveness, conflict, increases social adaptation;
• – improves mood;
• – makes it easier to fall asleep and normalizes sleep;
• – increases mental performance;
• – reduces vegetative-vascular disorders (including during menopause);
• – reduces the severity of brain disorders in ischemic stroke and traumatic brain injury;
• – reduces the toxic effect of alcohol and other drugs that depress the function of the central nervous system.

Pharmacokinetics:

easily penetrates into most biological fluids and tissues of the body, incl. into the brain; metabolized to water and carbon dioxide; accumulation in the body does not occur.

When should you increase your Glycine dose?

The drug should be taken according to the instructions, that is, no more than 3 tablets (300 mg) per day. The use of a large dose of the drug at one time (10 tablets or 1000 mg) is due to ischemic stroke or situations close to it.

If the goal of taking Glycine is to improve performance and mood, protect against central nervous system overload, prevent various diseases and maintain the desired level of amino acid in the body, there is no need to increase the dosage.

Remember that to achieve a therapeutic effect, it is important how to take Glycine, and not how many times a day. Glycine is applied sublingually or buccally. It is this taking of the drug that will provide the desired effect. If you just take the pills orally, there will be no harm, but there will be no positive effect either.

Indications for use

Indications for use:

• – reduced mental performance;
• – stressful situations - psycho-emotional stress (during exams, in conflict situations, etc.);
• – deviant (deviating from the norm) forms of behavior of children and adolescents;
• – various functional and organic diseases of the nervous system, accompanied by increased excitability, emotional instability, decreased mental performance, memory and sleep disturbances: neuroses, neurosis-like conditions and vegetative-vascular dystonia, stress nervous disorders, consequences of neuroinfections and traumatic brain injury, perinatal and others forms of encephalopathies (including those of alcoholic origin);
• - ischemic stroke.

Contraindications: hypersensitivity to glycine or other components of the drug.

Precautions for use: does not require special precautions.

Use during pregnancy and breastfeeding: Glycine is not recommended for use during pregnancy and breastfeeding due to the lack of sufficient data.

Biological role of glycine

Glycine is an inhibitory transmitter that, when overexcited, protects the nervous system from overload, providing protective inhibition. It has a calming property, but does not depress, but stimulates metabolic processes in neurons, as it stimulates cellular respiration. Therefore, after taking glycine as an anti-stress drug, there is no drowsiness or decreased cognitive function.

Glycine is an integral part of the mitochondrial respiratory chain, the Krebs cycle. During cellular respiration, glycine molecules are able to enhance the activity of oxidative reactions, increasing the efficiency of resource use to produce ATP. In case of intoxication, stress, or dysfunction of external respiration and blood circulation, the function of cellular respiration is disrupted, the cell suffers from a lack of ATP, which can lead to its death if problems with cell respiration are not resolved. Glycine helps solve the problem by restoring the activity of the Krebs cycle.

Directions for use and doses

Glycine is used sublingually or buccally (in tablets or in powder form after crushing the tablets): adults, adolescents and children over three years old - 1 tablet (100 mg), children under three years old - 0.5 tablets (50 mg).

Glycine is prescribed to practically healthy children, adolescents and adults for psycho-emotional stress, stress nervous disorders, decreased memory, attention, mental performance, mental retardation, and deviant forms of behavior: 2-3 times a day for 14-30 days.

For functional and organic lesions of the nervous system, accompanied by increased excitability, emotional lability and sleep disturbance:

• – children under three years of age: 2-3 times a day for 7-14 days, then 1 time a day for 7-10 days, daily dose - 100-150 mg, course dose - 2000-2600 mg;
• – children over three years old, adolescents and adults: 2-3 times a day for 7-14 days, daily dose - 200-300 mg, course dose - 2800-4200 mg;

On the recommendation of a doctor, the course of treatment can be increased to 30 days; if necessary, the course is repeated after 30 days.

For sleep disorders: 20 minutes before bedtime or immediately before bedtime, 0.5-1 tablet (depending on age).

For ischemic cerebral stroke: during the first 3-6 hours from the onset of stroke, 1000 mg is prescribed sublingually or buccally with one teaspoon of water, then for 1-5 days 1000 mg per day, then over the next 30 days 1-2 tablets 3 times a day.

In narcology, glycine is used as a means of increasing mental performance and reducing psycho-emotional stress during the period of remission in cases of encephalopathy, organic lesions of the central and peripheral nervous system: 1 tablet 2-3 times a day for 14-30 days. If necessary, courses are repeated 4-6 times a year.

Reception features

What factors determine how much Glycine you can take per day?

• Age
  . The drug can be given even to infants and taken in old age, so the dosage changes taking this factor into account.
• What is the drug used for
  ? How much Glycine you need per day depends on the reasons for use. For example, to improve sleep, half or one tablet is enough, but for a stroke, 10 tablets with a small amount of water are used at once.
• Individual appointment
  . Consultation with your doctor will help you adjust your dosage regimen and the number of tablets for daily use to achieve maximum effect.

Contraindications and side effects of glycine

As already mentioned, glycine is a natural substance that is constantly produced by our body and enters it in food, therefore glycine is familiar to the body and has no toxic effects. Only individual intolerance is indicated as a contraindication for glycine. In extremely rare cases, an allergy to glycine may occur and should be monitored for such reactions.

Considering that glycine has no serious contraindications or side effects, it is sometimes taken in large doses, but this can hardly be considered justified. It is better to follow the manufacturer's recommendations, and if you have any questions, consult your doctor.

Benefits of sublingual administration

Sublingual application provides a quick healing effect. The amino acid is absorbed in full and begins to act 20 minutes after administration.

But this method of application has one drawback - the appearance of irritation in the sublingual area. However, the development of such a condition in the oral cavity can only be caused by long-term use of the drug.

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More details

What are the benefits of glycine for the body?

Glycine is widely used in clinical practice, so it is well known to all of us - it is even given to infants so that they sleep more peacefully and develop better. In addition, glycine is used for hangover and withdrawal symptoms. Those. The benefit of glycine for the body is primarily in its nootropic effect (activating and facilitating brain activity). Despite weak evidence of its effects and unclear mechanisms of action, glycine is often used and shows good results as part of complex therapy.

Therefore, when analyzing the benefits and harms of glycine, we must know that it is a completely safe substance, the disadvantages of which are associated only with the weak validity of its effects. Glycine is often used in large doses, and although this is not encouraged, it does not cause any problems - glycine is present in our body all the time and has no toxic effects.

The second important function of glycine is to participate in the synthesis of collagen, a protein on which the health of joints, tendons, skin and almost all other organs depends. Medical research shows a link between good joint and tendon health and excess glycine in the diet.

Why do children need glycine?

The high metabolic rate in the nervous tissue in children is due to constant growth and development, so the need for glycine is also high. Also, with the help of the amino acid glycine, imperfections in the mechanisms of excitation and inhibition can be mitigated, as a result of which the child’s adaptation to biological and psychological factors improves.

A child’s need for glycine often cannot be met by the body’s own resources, so pediatricians prescribe it in the form of a drug. As in adults, Glycine in this case is a signaling molecule that activates the synthesis of its own amino acid. Glycine can help with a variety of childhood problems - night terrors, neuroses, poor adaptation to kindergarten and school, lack of self-confidence, poor performance, ADHD. Since this is a natural substance for the body, it can be taken for a long time without fear of side effects and overdose.

What foods contain glycine?

Considering that glycine is a very common amino acid found in many proteins (both plant and animal), especially collagen (up to 35% of its composition), glycine can be obtained from many foods. The greatest amount is found in soy protein (3.6-2.7%), spirulina (3.1%), chicken egg white (2.8%), octopus meat (1.9%), pumpkin seeds (1 .8%), parsley (1.8%), as well as meat, animal skin and offal (chicken, rabbit) in beef and veal (1.6%) – i.e. A lot of glycine is found in those foods that are rich in protein in general and collagen in particular.

For those who do not have the opportunity to include a lot of animal products in their diet, there are glycine supplements that allow you to benefit from its use without changing your diet.

Drugs

Glycine is available in different dosages and volumes. Therefore, the drug can be chosen for one or several courses.

Table - Glycine Supplements

Who is recommended to take glycine?

Considering the nootropic and proteinogenic properties of glycine, it is successfully used in many cases:

• athletes and everyone who suffers from overwork,
• those who experience increased stress on joints and tendons,
• students and people engaged in intense mental work,
• those who suffer from brain damage (only as prescribed by a doctor and as part of medical therapy).

Taking glycine can improve mental stability, increase performance, both mental and physical, reduce the negative effects of taking alcohol or medications, improve mood and relaxation, protect the ligaments and improve the health of the joints and vascular system.

In general, glycine is an affordable, safe and well-known remedy that is gentle and provides many benefits.