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Aktiferrin

Children have a high risk of intoxication with iron preparations; life-threatening conditions can occur when taking 1 g of iron sulfate. Therefore, iron supplements should be stored out of the reach of children.

Symptoms

: with accidental ingestion of very large doses of the drug, the following symptoms may be observed: weakness, fatigue, paresthesia, pale skin, cold clammy sweat, decreased blood pressure, palpitations, acrocyanosis, abdominal pain, bloody diarrhea, cyanosis, confusion, weak pulse, hyperthermia, lethargy, seizures, symptoms of hyperventilation, coma.

Signs of peripheral circular collapse appear within 30 minutes after administration; metabolic acidosis, convulsions, fever, leukocytosis, coma - within 12-24 hours; acute renal and hepatic necrosis - after 2-4 days.

Treatment

: before carrying out specific therapy, measures are taken to remove the drug that has not yet been absorbed from the stomach (gastric lavage), milk and raw eggs are given. Specific therapy is carried out by prescribing deferoxamine (desferal) orally and parenterally. In case of acute poisoning, to bind iron that has not yet been absorbed from the gastrointestinal tract, give 5-10 g of the drug by dissolving the contents of 10-20 ampoules in drinking water.

In case of advanced poisoning, deferoxamine is administered slowly intramuscularly, for children - 15 mg/hour, for adults - 5 mg/kg/hour (up to 80 mg/kg/day); for mild poisoning - children 1 g intramuscularly every 4-6 hours; adults - 50 mg/kg (up to 4 g/day).

In severe cases, accompanied by the development of shock in patients, 1 g of the drug is administered intravenously and symptomatic therapy is carried out. Death mainly occurs when patients are not treated in a timely manner due to shock. Hemodialysis is ineffective for removing iron, but can be used to accelerate the removal of the iron-deferoxamine complex, and can also be prescribed for oligo- and anuria. Peritoneal dialysis is also possible.

During a course of treatment with iron supplements, systematic monitoring of serum iron levels and other blood serum parameters is necessary.

Special measures: for severe intoxication - Unitaol (sodium dimercaptopropanesulfonate) parenterally.

Due to the possibility of the formation of neurotoxic complexes, Unitaol should be used with caution.

Analogs

Level 4 ATC code matches:
Ferroplex

Fenyuls

The closest analogues: Sorbifer Durules, Ferroplekt, Maltofer, Totema, Gemoferon, Ranferon-12, Feron Forte, Gemsineral - TD .

Which is better Maltofer or Aktiferrin?

Maltofer , unlike the original drug, contains a polymaltose complex of ferric hydroxide and has some advantages over ferrous iron . For example, the likelihood of poisoning in case of an overdose is greatly reduced, the drug is less toxic, better tolerated, does not interact with food and other drugs, and tooth enamel does not turn black. However, the cost of Aktiferrin is slightly lower than that of its analogue. Judging by reviews on the Internet, both products are quite effective. The incidence of adverse reactions from both drugs is the same.

Reviews about Aktiferrin

The drug has generally good reviews. It is well tolerated, side effects are infrequent. Many people like the relatively low cost and variety of dosage forms. Actiferrin Compositum was more suitable for many, as it was better absorbed.

Reviews of Aktiferrin for infants

The product raises hemoglobin levels well, the child becomes more active, and skin color improves. However, side effects still occur and it is difficult to wash off clothes.

Interaction

Tetracycline , ciprofloxacin , norfloxacin , ofloxacin , levofloxacin , penicillamine , carbidopa , levodopa and methyldopa under the influence of the drug may be poorly absorbed by the body; dose adjustment is required.

When combined with thyroxine and zinc, iron salts will be less absorbed in the stomach.

Citric and ascorbic acids enhance the absorption of iron.

Calcium, magnesium, chloramphenicol , cholestyramine, antacids containing aluminum, magnesium, calcium or bismuth reduce iron resorption.

When combined with glucocorticosteroids, of erythropoiesis may be enhanced .

Vitamin E reduces the activity of iron in the body, especially in children.

Compound

Aktiferrin drops (100 ml) contain 4.72 grams of ferrous sulfate heptahydrate ; 3.56 grams of serine + additional ingredients ( potassium sorbate, ethanol, raspberry and cream flavors, water, ascorbic acid, invert sugar syrup ).
In one capsule: 113.85 mg of ferrous sulfate monohydrate + 129 mg of serine + excipients ( lecithin, soybean oil, gelatin, beeswax, glycerol, rapeseed oil, sorbitol, black and red iron oxide ).

Per 100 ml of syrup there are 3.42 g of ferrous sulfate heptahydrate ; 2.58 g serine + sugar syrup, vitamin C , raspberry flavor, water, ethanol, cream flavor .

Aktiferrin Compositum capsules contain 113.85 mg of ferrous sulfate monohydrate ; 129 mg serine ; 0.5 mg folic acid + excipients ( beeswax, soy lecithin, rapeseed oil, soybean oil, sorbitol, gelatin, black iron oxide, glycerol, titanium dioxide, yellow iron oxide, titanium dioxide, brown iron oxide, shellac, red iron oxide, butanol, methanol, ethyl acetate ).

Pharmacodynamics and pharmacokinetics

Iron is a very important element for the normal functioning of the body. The substance is part of hemoglobin , cytochromes and myoglobin , participates in the process of oxygen transfer to all organs and tissues, stimulator of erythropoiesis . About 60% of the substance is part of red blood cells (hemoglobin) , 1 gram is the reticuloendothelial system of the liver and spleen . Iron is found in the bone marrow ; about 25 mg of the substance is found there every day.

The alpha amino acid serine improves iron absorption without requiring much less iron. It spreads faster throughout the body and is absorbed.

Folic acid is involved in the synthesis of amino acids , nucleic acids and nucleotides , and also takes part in erythropoiesis . The acid is very useful for pregnant women, protects against various teratogenic factors.

Absorption of the active components occurs in the duodenum and upper small intestine . About 15% of iron is absorbed here. However, if the patient has very low hemoglobin and increased erythropoiesis , then this figure can reach 50%. After 3 hours the drug reaches its maximum concentration in plasma.

Already in the bloodstream, iron binds to the enzyme transferrin and is transported to the necessary tissues and organs. The maximum amount of iron that reacted with the enzyme is 12 mg.

The deposition process takes place in the liver , bone marrow and spleen . Iron can cross the placenta and enter breast milk.

Every day the body loses up to 1 mg of iron, this occurs especially intensely in women during menstruation. After hemoglobin breaks down, the iron released in the process can be reused to synthesize a new oxygen carrier.

Contraindications

The medicine is not prescribed:

if you are allergic to the components of the drug;
for hemochromatosis and hemosiderosis ;
for anemia (including lead, sideroachrestic, thalassemia, hemolytic and caused by a lack of vitamin B12 );
if you take other products containing iron;
for serious gastrointestinal ( stenosis , intestinal obstruction );
with fructose or galactose intolerance;
if regular blood transfusions .

Side effects

Possible occurrence:

constipation , flatulence , diarrhea , abdominal pain, nausea, bitter taste in the mouth, loss of appetite;
weakness, headaches , dizziness , rarely – encephalopathy ;
pain or pressure in the chest, sore throat or toothache;
allergies , skin rashes, anaphylactic shock .

If there are disturbances in the gastrointestinal tract , you should try to reduce the daily dose, the symptoms should disappear.

Aktiferrin price, where to buy

The price of Aktiferrin drops is about 247 rubles per 30 ml.

The cost of 50 capsules of Actiferrin is 275 rubles.

The price of syrup is 198 rubles per 100 ml.

30 capsules of Actiferrin Compositum cost 241 rubles.

Online pharmacies in RussiaRussia
Online pharmacies in UkraineUkraine
Online pharmacies in KazakhstanKazakhstan

Pharmacy Dialogue

Aktiferrin (30ml bottle)Merckle GmbH
RUR 358 order

PaniPharmacy

Aktiferrin capsule Aktiferrin caps.
No. 20 Germany, Merckle 294 UAH. order
Aktiferrin liquid Aktiferrin drops 30ml Germany, Merckle
309 UAH. order

special instructions

bronchial asthma , rheumatoid arthritis , hepatitis , alcoholism , liver and kidney diseases, and diabetes should be careful .

Do not take tablets or capsules with black tea, milk, or coffee. Also, you should not simultaneously take (two hours apart) raw cereals, solid foods, bread, eggs and various dairy products.

The stool may turn black. In order to avoid staining your teeth black, you should brush your teeth after taking medications and do not drink undiluted syrup or drops.

Release form

drops are produced in the form of a transparent yellow-green solution with a raspberry smell and taste, in 30 ml bottles.

The drug is also produced in the form of dark brown capsules in a gelatin shell, inside the capsule there is a light beige oily liquid. The product is available in packs of 20 and 50 pieces.

syrup is transparent yellow-green, has a raspberry smell, with a capacity of 100 ml.

Aktiferrin Compositum - capsules are light brown on one side, dark brown on the other, on the tablet there is a white inscription “Aktiferrin F”, inside there is a grayish-yellow paste. There are 30 pieces in a package.