Cordiamine belongs to the group of respiratory analeptics with combined action. The drug affects the central nervous system, promoting the activation of the vasomotor and respiratory centers, which are located in the medulla oblongata. Cordiamine is often used for low blood pressure, since the active components of the drug can sharply increase blood pressure, which makes it an indispensable drug for relieving emergency conditions. However, for safe treatment with this medication, the correct dosage and optimal dosage regimen must be selected. What are the features of using the drug for hypotension and is it possible to use it for hypertension?
pharmachologic effect
Has an analeptic effect. Stimulates the central nervous system: has a stimulating effect on the vasomotor center of the medulla oblongata (especially when this center is depressed), which leads to an indirect increase in systemic blood pressure. Excites the respiratory center due to the stimulating effect on the chemoreceptors of the sinocarotid reflexogenic zone, which leads to an increase in the frequency and depth of respiratory movements. The drug does not have a direct stimulating effect on the heart and a direct stimulating vasoconstrictor effect.
Drug interactions
Enhances the effects of psychostimulants and antidepressants.
Reduces the effect of narcotic analgesics, hypnotics, antipsychotic and antiepileptic drugs, anxiolytics.
Reduces the effectiveness of niketamide: aminosalicylic acid, opiniazid, phenothiazine derivatives and drugs for general anesthesia.
The convulsive effect of the drug is enhanced by reserpine and aminazine.
The pressor effect of niketamide is enhanced by monoamine oxidase inhibitors.
Directions for use and doses
Adults are administered subcutaneously, intramuscularly and intravenously in a dose of 1-2 ml 1-3 times a day; for children - subcutaneously, depending on age, in a dose of 0.1-0.75 ml. Intravenous administration is carried out slowly. For intoxication with drugs, sleeping pills, analgesics, adults are given 3-5 ml of the drug intravenously (can be subcutaneously or intramuscularly). Since subcutaneous and intramuscular injections of cordiamine are painful, to reduce pain, depending on the situation, novocaine (1 ml of 0.5% solution) is first injected into the injection site. Higher doses for adults subcutaneously: single - 2 ml, daily - 6 ml. The highest single dose for subcutaneous and intravenous administration for drug poisoning is 5 ml.
Composition and release form
Solution - 1 ml:
- active ingredient - niketamide 250.0 mg;
- excipient - water for injection up to 1.0 ml.
Solution for injection 250 mg/ml, 1 ml or 2 ml in an ampoule.
5 ampoules in a blister pack made of polyvinyl chloride (PVC) or polyethylene terephthalate (PET) film.
1 or 2 blister packs together with instructions for use and an ampoule scarifier are placed in a pack of cardboard for consumer packaging or imported.
5 or 10 ampoules along with instructions for use and an ampoule scarifier are placed in a pack of cardboard for consumer packaging with a corrugated liner. When using ampoules with a break point or ring, do not insert an ampoule scarifier.
Packaging for hospitals.
4, 5 or 10 blister packs along with instructions for use in an amount equal to the number of blister packs are placed in a cardboard pack for consumer packaging.
50, 100 blister packs of ampoules along with an equal number of instructions for use are placed in a corrugated cardboard box.
Pharmacological properties
Under the influence of the medication, the transmission of nerve impulses to neurons is normalized, as a result of which the sensitivity and excitability of the respiratory center to the effects of various stimuli increases. Taking Cordiamin helps suppress the process of inhibition in the brain and activate impulses for a long time.
As a result of increased activity of the vasomotor center, peripheral vascular resistance increases, which increases blood pressure.
Features of reception at low pressure
Cordiamine at low pressure allows you to increase blood pressure in a short time. After taking the dosage forms of the drug, the nerve endings are irritated, which leads to the activation of vital processes in the body. The patient experiences a narrowing of the vascular lumen, resulting in an increase in blood pressure.
Taking Cordiamine is indicated for patients with increased arterial tone. The narrowing of the circulatory system occurs under the influence of certain structural elements of the brain, so the patient experiences a sharp increase in blood pressure. However, the indicators should be increased gradually so that the vessels can adapt to the new physiological state.
The dosage form for injection is used in situations requiring an emergency increase in blood pressure
The use of the drug must be agreed with a specialist, since the dose is selected depending on the severity of the pathology.
Mechanism of influence on pressure
Before starting a therapeutic course, it should be established whether Cordiamine increases or decreases blood pressure. The active substance is a respiratory analeptic with combined action. Niketamide has a central and peripheral mechanism of action. It has a direct effect on the structural elements of the brain (vasomotor and respiratory centers), as well as on nerve endings localized in the periphery.
The main mechanism of action is the stimulation of the vasomotor center, which is located in the medulla oblongata, as a result of which the drug increases blood pressure. An increase in the activity of the vasomotor center does not have a direct effect on pressure; it increases due to the transfer of impulse from the structural element of the brain to the vascular center. Due to the narrowing of the lumen of blood vessels, blood pressure levels can increase.
Important! Cordiamine does not have a direct effect on vascular tone and does not stimulate cardiac activity, since these effects occur reflexively.
Contraindications and side effects
The use of the drug is contraindicated in the presence of the following conditions, which in case of overdose can also be detected as side effects:
- allergic reaction to the active substance;
- predisposition to epileptic and convulsive seizures;
- hypertension;
- rapid heartbeat with normal blood pressure;
- hyperthermia;
- pregnancy period.
Important! While using Cordiamin, you should stop taking ascorbic acid, as they are incompatible. The medication enhances the effect of antidepressants and stimulants and reduces the therapeutic effect of analgesics, barbiturates, and tranquilizers.
Cordiamine is an effective remedy for both emergency and one-time increases in blood pressure. When taking the drug, you must follow the dose and take it only after prior consultation with a specialist.
For what conditions is it used?
Cordiamine has a strong pharmacological effect, so it is used to relieve emergency conditions when it is necessary to quickly restore respiratory function and stabilize blood pressure. Experts recommend using the drug for pathologies accompanied by impaired central and peripheral circulation, as well as a decrease in vascular tone.
So, the main indications for taking the drug are:
What pills increase blood pressure in a person?
- Collapse (characterized by a sharp decrease in blood pressure, as a result of which the blood circulation of vital organs is disrupted).
- Shock of various etiologies (progressive disorder of the functional activity of the nervous system, breathing, hemodynamics, metabolic reactions).
- Drug intoxication (poisoning with barbiturates, painkillers, narcotic substances).
- Cardiac disorder.
- Choking caused by laryngospasm or bronchospasm.
- Decreased respiratory activity (due to severe infections, brain injury).
- Hypotensive conditions (manifested by low blood pressure).
- Depression of respiratory function as a result of surgery and after it.
Only the attending physician can prescribe the drug, since uncontrolled use can lead to a worsening of the condition and cause a number of side effects.
Cordiamine 25% 30ml drops for oral administration
pharmachologic effect
Analeptic.
Composition and release form Cordiamine 25% 30ml drops for oral administration
Drops - 1 ml:
- Active ingredient: niketamide (nicotinic acid diethylamide) - 250.0 mg;
- Excipient: purified water up to 1 ml.
15, 25, 30 or 50 ml in a glass dropper bottle, sealed with a polyethylene dropper stopper and a screw cap.
Each dropper bottle, along with instructions for use, is placed in a cardboard pack.
Description of the dosage form
Transparent, colorless or slightly yellowish or greenish liquid with a characteristic odor.
Directions for use and doses
Inside, regardless of food intake.
Adults: 15-40 drops per dose 2-3 times a day. The highest single dose for adults is 60 drops, the daily dose is 180 drops.
Children over 10 years old: 10 drops 2-3 times a day.
Children under 10 years of age: 2-3 times a day, the number of drops per dose should be equal to the number of full years of the patient.
To determine the advisability of a course of use of the drug, you should consult your doctor.
Pharmacodynamics
Has an analeptic effect.
Stimulates the central nervous system: has a stimulating effect on the vasomotor center of the medulla oblongata (especially when this center is depressed), which leads to an indirect increase in systemic blood pressure.
Excites the respiratory center due to the stimulating effect on the chemoreceptors of the sinocarotid reflexogenic zone, which leads to an increase in the frequency and depth of respiratory movements.
The drug does not have a direct stimulating effect on the heart and a direct stimulating vasoconstrictor effect.
Pharmacokinetics
Well absorbed by any route of administration. It undergoes rapid biotransformation in the liver with the formation of inactive metabolites, excreted mainly by the kidneys.
Indications for use Cordiamine 25% 30ml drops for oral administration
Collapse, conditions accompanied by a decrease in blood pressure, decrease in vascular tone and weakening of breathing during infectious diseases and during the recovery period.
Contraindications
Hypersensitivity to the drug, epilepsy, history of seizures and predisposition to seizures, hyperthermia in children, pregnancy, breastfeeding.
With caution: children should use the drug only under the supervision of a doctor.
Application of Cordiamine 25% 30ml drops for oral administration during pregnancy and breastfeeding
The drug is contraindicated during pregnancy and breastfeeding.
If it is necessary to use cordiamine during lactation, breastfeeding should be discontinued.
special instructions
Impact on the ability to drive vehicles and operate machinery
During the period of treatment with the drug, you should refrain from performing potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions (driving vehicles, working with moving mechanisms, working as a dispatcher, operator).
Overdose
Symptoms: tonic-clonic convulsions, increased severity of side effects.
Treatment: symptomatic.
Side effects Cordiamine 25% 30ml drops for oral administration
From the gastrointestinal tract: vomiting.
From the cardiovascular system: heart rhythm disturbances.
From the nervous system: restlessness, anxiety, muscle twitching (starting from the orbicularis oris muscles), tonic-clonic convulsions, facial flushing.
Allergic reactions: itching of the skin.
Drug interactions
The convulsive effect of cordiamine is enhanced by reserpine; the stimulating effect on the respiratory center is eliminated by means of general anesthesia; the effect of the drug is weakened by aminosalicylic acid and opiniazid; Chlorpromazine and other phenothiazine derivatives lead to a weakening of the analeptic effect and convulsive effect.
Enhances the effects of psychostimulants and antidepressants.
Reduces the effect of narcotic analgesics, sleeping pills, neuroleptics, tranquilizers, anticonvulsants.
