Pharmacy No. 84. Delivery of medicines to your home and office.

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Compound

Ospamox capsules contain the active ingredient amoxicillin (250 mg).
The tablets contain the active ingredient amoxicillin (500 mg or 1000 mg). As auxiliary elements, the product contains polyvidone, magnesium stearate, sodium starch glycolate, talc, MCC, titanium dioxide, methylhydroxypropyl cellulose.

Ospamox granules contain the active ingredient amoxicillin (125 mg or 250 mg). As excipients, the composition contains sodium saccharin, simethicone, trisodium citrate anhydrous, guarana (gum), sodium benzoate, sucrose, flavoring.

pharmachologic effect

The drug is an antibiotic that belongs to the group of penicillins , beta-lactam antimicrobial agents. Provides a wide range of antimicrobial effects.

The active ingredient amoxicillin is part of the aminopenicillin subgroup. Produces a pronounced bactericidal effect, acts on a number of microorganisms, both gram-positive and gram-negative. Its mechanism of action is associated with the ability of the active substance to inhibit the synthesis of peptidoglycan, which forms the basis of the bacterial cell membrane. peptidoglycan formation at the final stage is disrupted under the influence of amoxicillin due to inhibition of the enzymatic activity of penicillin-binding proteins. Since the structure of the cell membrane is disrupted during their reproduction and growth, the integrity of the cell membranes is disrupted and bacterial lysis is observed.

Amoxicillin does not have a toxic effect on the body, since mammals do not have peptidoglycan and penicillin-binding proteins, which are affected by the drug.

Amoxicillin is an unprotected penicillin; it is destroyed by beta-lactamases. Therefore, those bacteria that produce penicillinase demonstrate resistance to Ospamox.

The drug is effective in the treatment of infectious diseases that were caused by microorganisms that are sensitive to the effects of amoxicillin.

Citrobacter, Klebsiella, Proteus vulgaris, Bacteroides fragilis, Enterobacter, Serracia, Acinetobacter, Moraxella catarrhalis, Riketsia, Providencia, Chlamidia, Mycoplasma, Proteus, Pseudomonas do not demonstrate sensitivity to the influence of the active substance.

Analogs

Level 4 ATC code matches:
Hiconcil

Ampioks

Ampicillin Trihydrate

Ampicillin

Amoxicar

Penicillin

Flemoxin Solutab

Amoxicillin

Amosin

Amoxil

Ecoball

Analogues of this drug, containing a similar component as an active substance, are the following drugs: Amoxicillin , Amosin , Gonoform , Grunamox , Flemoxin Solutab , Danemox , Ecobol , etc.

Any of the analogues can be taken instead of Ospamox only after a doctor’s prescription.

Side effects

Ospamox 250 suspension, 500 mg tablets and Ospamox 1000 mg are generally well tolerated by patients. But sometimes during the treatment the development of such negative effects was noted:

Gastrointestinal tract: nausea, anorexia , vomiting, abdominal pain, flatulence , stool disorders, feeling of dry mouth; change in taste, temporary discoloration of the tongue in a black tint, change in the color of teeth - in isolated cases.
Central nervous system, peripheral nervous system : dizziness , hyperkinesia , fainting; People with kidney disease may experience seizures.
Liver and kidneys: temporary changes in the activity of liver transaminases, interstitial nephritis .
Allergies: itching, rash, urticaria , exanthema , erythema multiforme , dermatitis ; Stevens-Johnson syndrome , anaphylactic shock , Quincke's edema , toxic epidermal necrolysis may develop .
Hematopoiesis: agranulocytosis , thrombocytopenia .
Other manifestations: superinfection, fever , fungal infections of the mucous membranes, in particular candidiasis .

If side effects develop, you need to stop treatment and consult a specialist.

Interaction

With the simultaneous use of phenylbutazone , probenecid , oxyphenbutazone , acetylsalicylic acid , sulfinpyrazone , the half-life of amoxicillin and its concentration in the blood increases.

When taking macrolides, tetracycline antibiotics, chloramphenicol the bactericidal effect of amoxicillin can be neutralized.

It is not recommended to take amoxicillin at the same time as Allopurinol to avoid allergic reactions to the skin.

With simultaneous use, the absorption of Digoxin , therefore, its dose needs to be adjusted.

Concomitant use with Disulfiram .

In case of simultaneous administration of Ospamox with anticoagulants of the coumarin , bleeding time may increase, so dose adjustment is necessary.

When taking amoxicillin and methotrexate , the toxic effect of the latter increases. The renal clearance of Methotrexate is reduced, therefore, its concentration in plasma must be monitored.

Caution: Ospamox should be combined with hormonal oral contraceptives , since their effectiveness may be reduced with this combination. During the treatment period, it is recommended to use additional non-hormonal contraception.

Contraindications

Antibiotics should not be taken for the following diseases and conditions:

high sensitivity to the components of the product, as well as to cephalosporins and beta-lactam antibiotics;
children under 10 years of age (tablets);
Infectious mononucleosis;
epilepsy;
acute lymphocytic leukemia ;
severe gastrointestinal infections, which include diarrhea and vomiting;
allergic diathesis;
bronchial asthma;
respiratory viral infections;
hay fever.

The drug is prescribed with caution to people with meningitis and impaired renal function.

Pharmacokinetics and pharmacodynamics

The active substance after oral administration is absorbed in the small intestine. Depending on the dose that was taken, the level of bioavailability is from 75 to 90%. The rate of absorption is not affected by food intake. The highest concentration of the substance in plasma is recorded 1-2 hours after oral administration. 17% bound to plasma proteins.

It is well distributed in body fluids and tissues. Passes through the placenta and into breast milk. High concentrations of the component are detected in bile , pus , and bronchial secretions .

It penetrates the blood-brain barrier poorly, but in people who suffer from meningitis , there is an increase in this indicator.

Part of Amoxicillin is metabolized, resulting in the formation of penicillin acid, an inactive metabolite. It is mainly excreted through the kidneys, a small part - with bile. The half-life is 1-2 hours. In people suffering from kidney disease, the half-life increases to 5-20 hours.

Overdose

If Ospamox was taken in large doses, a person may develop nausea, stool disorders, vomiting and, as a result, disturbances in the water-salt balance in the body. There is no specific antidote. In case of overdose, the patient’s stomach should be rinsed, saline laxatives and enterosorbents should be given. If the water-salt balance is disrupted, measures must be taken to restore the balance of electrolytes and water. The active component Ospamox is eliminated by hemodialysis .

Indications for use

Ospamox is indicated for use in the treatment of infectious diseases caused by microorganisms sensitive to amoxicillin:

Diseases of the respiratory and ENT organs of an infectious nature: lung abscess , acute and chronic bronchitis pneumonia , otitis media , pharyngitis , sinusitis , the initial stage of whooping cough .
Diseases of the urinary system of infectious origin: prostatitis , urethritis , cystitis , pyelonephritis ; prescribed to pregnant women for the treatment of asymptomatic bacteriuria .
Diseases of the reproductive system of infectious origin: endometritis , septic abortion, uncomplicated gonorrhea .
Diseases of soft tissues and skin of infectious origin: erysipelas , impetigo , infected dermatitis .
Diseases of the gastrointestinal tract, biliary tract, liver of an infectious nature: cholecystitis (without cholestasis), paratyphoid fever , shigellosis , salmonella , typhoid fever .
Other diseases: listeriosis , leptospirosis , infective endocarditis .

The drug can also be prescribed for the treatment of septicemia , bacterial meningitis , and for the prevention of infections during minor surgical interventions, if there is no need to take antibiotic injections.

During pregnancy and lactation

Since amoxicillin can cross the placenta, during pregnancy this drug is prescribed only after comparing the likely benefits and harms.

It is found in breast milk in small quantities. There is a possibility that a breastfed baby may experience highly sensitive reactions. Therefore, Ospamox can be used during lactation only after careful comparison of the likely risks and benefits. If the child has had gastrointestinal disorders, breastfeeding should be stopped.