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General information

Trade name Galavit®
Registration number P N000088/03

INN or group name Aminodihydrophthalazindione sodium

Chemical name 5-amino-1,2,3,4-tetrahydrophthalazine-1,4-dione sodium salt

Dosage form Rectal suppositories

Compound

Active substance - sodium aminodihydrophthalazindione (Galavita) 100 mg; excipients - vitepsol W-35 (fatty acid glycerides) - 575 mg, vitepsol H-15 (fatty acid glycerides) - 575 mg.

Pharmacotherapeutic group

Immunomodulatory and anti-inflammatory agent.

ATX code L03, G02

Pharmacological properties

Pharmacodynamics

The mechanism of action of the drug is associated with the ability to influence the functional and metabolic activity of macrophages.

In inflammatory diseases, the drug reversibly inhibits for 6-8 hours the excessive synthesis of tumor necrosis factor, interleukin-1 and other pro-inflammatory cytokines, reactive oxygen species by hyperactivated macrophages, which determine the degree of inflammatory reactions, their cyclicity, as well as the severity of intoxication. Normalization of the functional state of macrophages leads to the restoration of the antigen-presenting and regulatory functions of macrophages and a decrease in the level of autoaggression. Stimulates the bactericidal activity of neutrophil granulocytes, enhancing phagocytosis and increasing the body's nonspecific resistance to infectious diseases.

Pharmacokinetics

It is excreted from the body mainly through the kidneys. After rectal administration, the half-life is 40-60 minutes. The main pharmacological effects are observed within 72 hours.

Russia, 123290, Moscow, dead end Magistralny 1st, 5A, room. 91 Tel/fax 8-800-707-71-81 E-mail: [email protected] ; https://www.galavit.ru Address of production site 308013, Belgorod, st. Rabochaya, 14 Send claims to the address 123290, Moscow, dead end Magistralny 1st, 5A, room. 91. Tel. 8-800-707-71-81

Indications for use

In adults and adolescents over 12 years of age (including those with secondary immune deficiency) as an immunomodulatory and anti-inflammatory agent in complex therapy:

infectious intestinal diseases accompanied by intoxication and/or diarrhea
peptic ulcer of the stomach and duodenum
viral hepatitis
chronic recurrent diseases caused by the herpes virus
diseases caused by human papillomavirus
infectious and inflammatory urogenital diseases (urethritis of chlamydial and trichomonas etiology, chlamydial prostatitis, acute and chronic salpingoophoritis, endometritis)
purulent-inflammatory diseases of the pelvic organs
postoperative rehabilitation of patients with uterine fibroids
complications of the postoperative period in women of reproductive age
purulent surgical diseases (burn lesions, chronic osteomyelitis, gangrenous appendicitis with omentitis, peritonitis, purulent pleurisy)
postoperative purulent-septic complications and their prevention (including in cancer patients)
chronic recurrent furunculosis, erysipelas
asthenic conditions, neurotic and somatoform disorders, decreased physical performance (including in athletes); mental, behavioral and post-withdrawal disorders in alcohol and drug addiction
inflammatory diseases of the mucous membrane of the mouth and throat, periodontal diseases
frequent recurrent diseases of the respiratory tract and ENT organs of bacterial and viral etiology (frequent ARVI, bronchitis, pneumonia, chronic tonsillitis, chronic otitis media, chronic adenoiditis) and their prevention

Directions for use and doses

For acute infectious intestinal diseases accompanied by diarrhea syndrome: the initial dose is 2 suppositories once, then 1 suppository 2 times a day until the symptoms of intoxication are relieved. It is possible to subsequently continue the course of 1 suppository with an interval of 72 hours. A course of 20-25 suppositories.
For gastric and duodenal ulcers in the acute period: 2 days, 2 suppositories once a day, then 1 suppository at intervals of 72 hours. A course of 15-25 suppositories. In the chronic period: 5 days, 1 suppository once a day, then one suppository every 72 hours. Course of 20 suppositories.
For viral hepatitis: the initial dose is 2 suppositories once, then one suppository 2 times a day until the symptoms of intoxication and inflammation subside. Subsequent continuation of the course of 1 suppository with an interval of 72 hours. Course 20 -25 suppositories.
For chronic recurrent diseases caused by the herpes virus: 1 tablet 4 times a day for 10 days. Then 1 tablet 4 times a day every other day for 10 days.
For diseases caused by the papilloma virus: 5 days, 1 suppository once a day, then one suppository every other day. Course – 20 suppositories.
For urogenital diseases - urethritis of chlamydial and trichomonas etiology, chlamydial prostatitis: 1 day, 1 suppository twice, then one suppository every other day. A course of 10-15 suppositories (depending on the severity of the pathological process).
For salpingoophoritis, endometritis in the acute period: 2 days, 2 suppositories once a day, then one at an interval of 72 hours. In the chronic period: 5 days, 1 suppository once a day, then one every 72 hours. Course - 20 suppositories.
For acute and chronic purulent diseases of the pelvic organs - in the acute period: 1 day, 2 suppositories once, 3 days, one suppository daily, then one every other day for 5 days. Course - 10 suppositories. In the chronic period: 5 days, 1 suppository once a day, then one every 72 hours. Course - 20 suppositories.
For postoperative rehabilitation of patients with uterine fibroids and complications of the postoperative period in women of reproductive age: 5 days, 1 suppository once a day, then one suppository every other day. Course - 15 suppositories.
For the prevention and treatment of surgical complications in the pre- and postoperative period (including in cancer patients): 1 suppository is prescribed once a day - 5 suppositories before surgery, 5 after surgery, one every other day and 5 suppositories at intervals 72 hours. In severe cases of the disease, the initial dose is 2 suppositories once or 2 times a day, one at a time. Course - 20 suppositories.
For chronic recurrent furunculosis, erysipelas: 5 days, one suppository once a day, then one suppository every other day. Course - 20 suppositories.
For asthenic conditions, neurotic and somatoform disorders, for mental, behavioral and post-abstinence disorders, in patients with alcohol and drug addiction: 5 days, one suppository daily, then one suppository every 72 hours. A course of 15-20 suppositories. To increase physical performance: 1 suppository every other day – 5 suppositories, then one suppository after 72 hours, course – up to 20 suppositories.
For inflammatory diseases of the mucous membrane of the mouth and throat, periodontal diseases: initial dose of 1 suppository daily - 5 suppositories, then one at an interval of 72 hours. Course 15 suppositories.
For nonspecific prevention and treatment of influenza and acute respiratory infections, one suppository 1 time per day. Course 5 days.

Precautionary measures

Contraindications

Individual intolerance; pregnancy and lactation.

Side effects

In rare cases, allergic reactions are possible.

Interaction with other drugs

With simultaneous use, it is possible to reduce the course doses of antibiotics. There are no cases of incompatibility with other drugs.

Shelf life, storage conditions

Storage conditions: Store at a temperature not exceeding 25 ° C, in a place protected from light. Keep out of the reach of children.

Shelf life: 3 years. Do not use after the expiration date indicated on the carton.

Conditions for dispensing from pharmacies Dispensed without a prescription.

Galavit® (Galavit)

Sublingually, 1 tablet daily up to 4 times a day or 2 tablets daily up to 2 times a day, depending on the diagnosis and severity of the disease.

— For acute infectious intestinal diseases accompanied by diarrhea syndrome:

The initial dose is 2 tablets - once, then 1 tablet 3-4 times a day until the symptoms of intoxication subside for 3-5 days.

— For peptic ulcer of the stomach and duodenum in the acute period:

for the first 2 days, take 1 tablet 4 times a day, then every 3 days, 1 tablet 4 times a day, course 2-3 weeks. In the chronic period, use: 5 days, 1 tablet 4 times a day, then every 3 days, 1 tablet 4 times a day for a course of up to 3 weeks.

— For viral hepatitis of various etiologies:

in the acute period of the disease, the initial dose is 2 tablets 2 times a day until the symptoms of intoxication and inflammation are relieved. It is possible to subsequently continue the course of 1 tablet 4 times a day every 3 days for a course of up to 2-3 weeks.

— For chronic recurrent diseases caused by the herpes virus:

1 tablet 4 times a day for 10 days. Then 1 tablet 4 times a day every other day for 10 days.

— For diseases caused by the human papillomavirus:

5 days, 1 tablet 4 times a day, then 1 tablet 4 times a day, every other day for a course of up to 2-3 weeks.

- For urogenital diseases - urethritis of chlamydial and trichomonas etiology, chlamydial prostatitis:

on the first day 2 times 2 tablets, then 1 tablet 4 times a day every other day for a course of up to 2 weeks (depending on the severity of the pathological process).

— For salpingoophoritis, endometritis:

in the acute period, 2 days, 2 tablets 2 times a day, then 1 tablet 4 times a day every 3 days for 3 weeks. In the chronic period - 5 days, 1 tablet 4 times a day, then 1 tablet 4 times a day every 3 days for a course of up to 2-3 weeks.

— For acute and chronic purulent diseases of the pelvic organs:

in the acute period - On the first day, 2 tablets 2 times a day, then 3 days, 1 tablet 4 times a day, then 1 tablet 4 times a day, every other day for 10 days. In the chronic period - 5 days, 1 tablet 4 times a day, then 3-4 tablets every 3 days for a course of up to 3 weeks.

— For postoperative rehabilitation of patients with uterine fibroids and complications of the postoperative period in women of reproductive age:

5 days, 1 tablet 4 times a day, then 1 tablet 4 times a day, every other day for a course of up to 2 weeks.

— For purulent surgical diseases (burn lesions, chronic osteomyelitis, gangrenous appendicitis with omentitis, peritonitis, purulent pleurisy):

apply 4 times a day, 1 tablet for 5 days, then 1 tablet 4 times every other day for up to 15 days.

— For the prevention and treatment of surgical complications in the pre- and postoperative period (including in cancer patients)

Prescribe 1 tablet 4 times a day for 5 days before surgery, for 10 days after surgery, 1 tablet 4 times every other day, and for 3 weeks, 1 tablet 4 times every 3 days. In case of severe disease, on the first day, 2 tablets 2 times a day.

— For chronic recurrent furunculosis, erysipelas:

5 days, 1 tablet 4 times a day, then 1 tablet 4 times every other day for a course of up to 3 weeks.

— For asthenic conditions, neurotic and somatoform disorders, for mental, behavioral and post-abstinence disorders, in patients with alcohol and drug addiction:

5 days, 1 tablet 4 times a day, then 1 tablet 4 times every 3 days for 3 weeks. To increase physical performance: 1 tablet 4 times every other day for 10 days, then 1 tablet 4 times a day after 3 days for a course of up to 3 weeks.

— For inflammatory diseases of the mucous membrane of the mouth and throat, periodontal diseases:

initial dose: 1 tablet 4 times a day for 5 days, then 1 tablet 4 times a day after 3 days for a course of up to 3 weeks

— For frequent recurrent diseases of the respiratory tract and ENT organs of bacterial and viral etiology (frequent ARVI, bronchitis, pneumonia, chronic tonsillitis, chronic otitis media, chronic adenoiditis):

apply 4 times a day, 1 tablet for 5 days, then 1 tablet 4 times every other day for up to 15 days. For the prevention of acute respiratory infections and flu, 1 tablet 2 times a day. Course 5-10 days.

Galavit candles

Rectally. The suppository is released from the contour packaging and then inserted into the rectum. It is recommended to empty the intestines first. The dose and duration of use of the drug depends on the nature, severity and duration of the disease. - For urogenital diseases - urethritis of chlamydial and trichomonas etiology, chlamydial prostatitis: 1 day, 1 suppository twice, then one suppository every other day. A course of 10-15 suppositories (depending on the severity of the pathological process). — For salpingoophoritis, endometritis in the acute period: 2 days, 2 suppositories once a day, then one at an interval of 72 hours. In the chronic period: 5 days, 1 suppository once a day, then one every 72 hours. Course - 20 suppositories. — For acute and chronic purulent diseases of the pelvic organs — in the acute period: 1 day, 2 suppositories once, 3 days, one suppository daily, then one every other day for 5 days. Course - 10 suppositories. In the chronic period: 5 days, 1 suppository once a day, then one every 72 hours. Course - 20 suppositories. - For chronic recurrent diseases caused by the herpes virus: 1 suppository daily - 5 suppositories, then one every other day - 15 suppositories. — For diseases caused by the papilloma virus: 5 days, 1 suppository once a day, then one suppository every other day. Course – 20 suppositories. — For postoperative rehabilitation of patients with uterine fibroids and complications of the postoperative period in women of reproductive age: 5 days, 1 suppository once a day, then one suppository every other day. Course - 15 suppositories. - For the prevention and treatment of surgical complications in the pre- and postoperative period (including in cancer patients): 1 suppository is prescribed once a day - 5 suppositories before surgery, 5 - after surgery, one every other day and 5 suppositories - c every 72 hours. In severe cases of the disease, the initial dose is 2 suppositories once or 2 times a day, one at a time. Course - 20 suppositories. — For chronic recurrent furunculosis, erysipelas: 5 days, one suppository once a day, then one suppository every other day. Course - 20 suppositories. — For nonspecific prevention and treatment of influenza and acute respiratory infections: one suppository 1 time per day. Course 5 days. — For inflammatory diseases of the mucous membrane of the mouth and throat, periodontal diseases: initial dose of 1 suppository daily - 5 suppositories, then one at an interval of 72 hours. Course 15 suppositories. — For viral hepatitis: the initial dose is 2 suppositories once, then one suppository 2 times a day until the symptoms of intoxication and inflammation subside. Subsequent continuation of the course of 1 suppository with an interval of 72 hours. Course 20 -25 suppositories. — For acute infectious intestinal diseases accompanied by diarrhea syndrome: the initial dose is 2 suppositories once, then 1 suppository 2 times a day until the symptoms of intoxication are relieved. It is possible to subsequently continue the course of 1 suppository with an interval of 72 hours. A course of 20-25 suppositories. — For gastric and duodenal ulcers in the acute period: 2 days, 2 suppositories once a day, then 1 suppository with an interval of 72 hours. A course of 15-25 suppositories. In the chronic period: 5 days, 1 suppository once a day, then one suppository every 72 hours. Course of 20 suppositories. — For asthenic conditions, neurotic and somatoform disorders, for mental, behavioral and post-abstinence disorders, in patients with alcohol and drug addiction: 5 days, one suppository daily, then one suppository every 72 hours. A course of 15-20 suppositories. — To increase physical performance: 1 suppository every other day - 5 suppositories, then one at a time - after 72 hours, course - up to 20 suppositories.