"Creon" is a medicine that is used as an additional source of digestive enzymes. Normally, these compounds should be synthesized in the pancreas. But in case of insufficient functions, the deficit must be replenished from an additional source. The medicine contains pancreatic enzymes, including:
- amylase;
- pancreatin;
- proteases of different composition;
- lipase.
Available in the form of gelatin-coated capsules. One package contains 10, 20 or 50 capsules.
Pharmacodynamics
This enzyme preparation, as Wikipedia indicates, is intended to improve digestive processes. The pancreatic enzymes included in its composition promote the breakdown of proteins, fats and carbohydrates, leading to complete absorption in the small intestine. The main substance pancreatin is also the INN of the drug.
According to the abstract, the capsule shell easily dissolves in the stomach, resulting in the release of many mini-microspheres. Thus, mini-microspheres are mixed with intestinal contents, improving the distribution of enzymes within the intestine.
Pancreatic juice and its enzymes
The pancreas (P) produces pancreatic juice, which, unlike gastric juice, has a pronounced alkaline reaction. Pancreatic juice contains amylase, lipase and protease, and other enzyme compounds. These substances are involved in the breakdown of proteins, fats and carbohydrates and help food to be absorbed. Enzymes are produced by the gland in the form of proenzymes, and their activation, that is, transformation into active enzymes, occurs in the intestinal lumen. This is necessary to avoid damage to pancreatic cells.
During normal functioning of the gland, pancreatic juice begins to be produced some time after eating. If a person is hungry, the pancreas does not secrete secretions. During meals, gastric digestion is activated and gastric juice is released. This signals the pancreas to begin its work. Its liquid enters the duodenum, where proenzymes are activated and the digestion process begins. Pancreatic juice production naturally decreases 9-10 hours after eating. At the next meal, this process is activated again.
The secretion of pancreatic juice is promoted by the consumption of acidic foods and drinks, and small portions of alcohol. The mucous membrane of the duodenum produces special hormones that are also involved in the regulation of the secretion of pancreatic juice. A decrease or increase in its production can be caused by the entry of certain drugs into the body or changes in the functioning of the nervous system.
With diseases of the pancreas or its partial removal due to pathology, the patient develops a deficiency of enzymes and hormones produced by the organ. In this case, replacement therapy, which includes insulin preparations and enzyme agents, helps normalize the condition.
Indications for use of Creon
The main indications for use are:
- carrying out replacement treatment for insufficient exocrine pancreatic function accompanying the following diseases: cystic fibrosis , chronic pancreatitis , pancreatectomy , pancreatic cancer , obstruction of the gastrointestinal tract due to neoplasms, Shwachman-Diamond syndrome , as well as in elderly patients;
- symptomatic treatment of digestive disorders with: partial gastrectomy , total gastrectomy , biliary obstruction , liver cirrhosis , cholestatic hepatitis , terminal pathologies and excessive bacterial growth in the small intestine.
Indications for taking Creon 10000 in adults
The pancreas has hormonal and exocrine functions. The hormonal function is to produce insulin, which is necessary for the absorption of glucose by cells. Exocrine function is characterized by the production and release of pancreatic enzymes. They have enzymatic activity and participate in the breakdown of protein, fat and carbohydrate compounds.
In many diseases, there is a decrease in the secretion of pancreatin or its increased destruction in the intestinal lumen. This leads to symptoms of enzyme deficiency. Patients with the following diseases encounter this phenomenon:
- chronic pancreatitis and its complications;
- cystic fibrosis;
- disturbances in the functioning of the pancreas due to chronic cholecystitis, obstruction of the bile ducts;
- tumor diseases of the gland;
- surgical removal of part of an organ;
- gastrectomy.
Enzyme deficiency can occur in patients without pancreatic pathology in the event of improper nutrition. The secretion of enzymes worsens with overeating, an abundance of heavy fatty foods in the diet, and large gaps between meals.
Creon capsules, instructions for use (Method and dosage)
Instructions for use Creon 10000 recommends prescribing them to small patients. In general, this drug of any quantity of units is taken orally. The dosage is selected individually and depends on age, severity of the disease and type of diet. It is usually recommended to take part of the medicine before meals, and the rest with food.
At the beginning of treatment, tablets are prescribed in a dosage of 10,000–25,000 units. When it is necessary to reduce steatorrhea and maintain optimal patient condition, the dose may be increased. In medical practice, patients can receive an average of 20,000–50,000 units of EP lipase.
During the treatment of cystic fibrosis, the dosage is determined depending on the weight. For example, when treating small patients under 4 years of age, 1000 lipase units per kg of weight are prescribed, and over 4 years of age, 500 lipase units per kg of weight with each meal. For many patients, the daily dosage should not exceed 10,000 units per 1 kg of weight.
Instructions for use Creon 25000 recommends taking it in the treatment of other conditions that may be accompanied by exocrine pancreatic insufficiency. In this case, the dose is set taking into account the individual characteristics of the patient, for example, how much digestion is impaired, how much fat is contained in the food, and so on.
Instructions for use of Creon for children contain a detailed description of how to give it to children with difficulty swallowing. To use this drug for children, the capsules must be carefully opened. The internal contents are mixed with liquid or food that does not require chewing. It must be remembered that such mixtures cannot be stored, so take them immediately after they are prepared. It is forbidden to crush or chew mini-microspheres and add them to acidic foods - this can destroy their shell, which protects them from the effects of gastric juice.
Instructions for use Creon 40000 recommends taking this drug for adult patients. Its dosage also depends on the severity of the disease and the personal characteristics of the patient. The duration of use must be determined by the attending physician.
Special instructions for the use of the drug Creon
In patients with cystic fibrosis who took high doses of other pancreatin preparations, narrowing of the ileocecal intestine and colon (fibrosing colonopathy), as well as colitis, was noted, but controlled studies failed to provide evidence of an association between taking Creon and the occurrence of fibrosing colonopathy. However, as a precautionary measure, it is necessary to exclude the possibility of damage to the colon in the event of unusual abdominal symptoms or a change in the nature of the symptoms of the underlying disease, especially if the patient is taking more than 10,000 IU lipase/kg/day. Use during pregnancy and lactation. Due to the fact that there is no clinical trial data on the effect of pancreatic enzymes on the course of pregnancy, the drug should be prescribed with caution during pregnancy. Animal studies have shown no evidence of absorption of pancreatic enzymes. Thus, the possibility of toxic effects on reproductive function and fetal development is excluded. Since animal studies indicate that there is no systemic exposure to pancreatic enzymes in women during breastfeeding, no effect on the breastfed infant has been identified. Children. Creon can be used for children. The ability to influence the reaction rate when driving a vehicle or while working with other mechanisms. There is no data on the negative effect of the drug Creon on the ability to drive vehicles or operate other mechanisms.
special instructions
There have been cases when patients treated for cystic fibrosis received pancreatin in high dosages, which caused colitis , strictures of the cecum and ileum.
For this reason, it is necessary to monitor the dose, especially when Creon 40000 is prescribed. It is also necessary to monitor the appearance of any symptoms and changes that occur in the abdominal cavity. In addition, you should immediately find out how to take Creon to 10,000 adult patients and not exceed its dosage.
Side effects and contraindications
"Creon 10000" has no contraindications except in cases of hypersensitivity to the components of the product. As for side effects, unwanted reactions most often occur from the digestive system. Some patients experience the following symptoms:
- nausea and vomiting;
- abdominal pain;
- bowel dysfunction (diarrhea or constipation);
- strictures (narrowing of the lumen) of the intestine (with prolonged treatment with high doses);
- flatulence.
Taking Creon 10000 in adults can lead to rashes, itching, and redness of the skin. The frequency of allergic reactions is low.
As a rule, if the dosage is correctly chosen and the patient follows the rules of administration, the drug is well tolerated.
Creon for children
An enzyme preparation is prescribed to children when they need to improve digestion. The recommended daily dosage of Creon 10,000 for children is divided into several parts and taken with each meal.
When prescribing it, parents need to immediately find out from the doctor how to take Creon for children, since the dose is prescribed taking into account the baby’s weight.
It should be noted that reviews for the child are very ambiguous. Some mothers report the effectiveness of the capsules, but there are also reviews about the uselessness of this medicine.
Creon for babies
When this drug is prescribed to children, many parents immediately have questions: what is Creon and what is it taken for? It is known that the gastrointestinal tract of newborns develops over a certain period of time. Therefore, even small deviations in the diet for infants can cause problems.
Also, mothers begin to worry about how to give capsule medicine to their infant? In fact, the pediatrician explains all this in detail and describes the instructions for the drug. It should be noted that Creon 10000 is usually prescribed for newborns, indicating the dosage, regimen and duration of therapy.
Reasons to prescribe capsules for newborns are:
- constant colic;
- constipation or diarrhea with particles of undigested food;
- bloating.
By the way, reviews from parents show that the question of how to give this medicine to a baby is not a problem at all. Many mothers are confused by the effect of the drug, since its effectiveness is not always evident.
How to take Creon
The dosage of Creon 10,000 in adults is determined by the patient’s health condition and the degree of enzyme deficiency. Gelatin capsules with pancreatin are taken with or immediately after meals. This applies not only to full meals, but also to snacks.
Capsules must be swallowed whole with plenty of water. If the medicine is taken by an elderly person, a bedridden patient who has difficulty swallowing, you can open the shell and mix the contents of the capsules with soft food. Here you need to follow some rules:
- Food should not be hot.
- You can use products with a sour taste. Kefir or yogurt, sour fruit juice, fruit or vegetable puree are suitable for mixing.
- After stirring the minimicrospheres, the contents should be taken orally immediately. Enzymes mixed with food cannot be stored, including in the refrigerator.
- It is not advisable to chew minimicrospheres during administration. Chewing leads to the destruction of the protective shell of the granules and the release of active components into the mouth. This reduces the effectiveness of the drug and can lead to irritation of the oral mucosa.
- When taking enzyme preparations, you should monitor your drinking regime. If there is a lack of fluid, taking Creon 10000 can cause constipation.
Analogues of Creon
Level 4 ATC code matches:
Digestin
Pancitrate
Mezim
Festal
Pankreoflat
Pancreazim
Enterosan
Panzinorm Forte
Panzinorm
Micrasim
Enzistal P
Pancreatin
Penzital
Pangrol
Hermital
Abomin
The main analogues of Creon 10000 and other units:
- Panzinorm
- Micrasim
- Penzital
- Pangrol
- Mezim
- Pancreazim
- Gastenorm
- Enzistal
- PanziCam
- Pancreatin
However, this does not mean that each of them is an equivalent substitute.
It should be noted that the price of analogues can be very different and cannot incline towards the purchase of one or another medicine. The question of what can replace treatment should be clarified with a doctor. Especially when the medicine is selected for children under one year of age.
Creon or Pancreatin - which is better?
Despite many similarities, each of these drugs has significant differences. But if you know what the difference is, then you can make the right choice when buying a medicine.
If we compare how Creon differs from Pancreatin , then the first is the form of release. Pancreatin is available in tablets. The second difference is the concentration of the active substance, which in Pancreatin is presented in arbitrary content.
The effect of drugs is also different - Pancreatin already acts in the stomach and therefore does not fully perform its function, which is why it is considered less effective. Although its cost is much lower.
Thus, based on these data, each patient will be able to decide which drug to choose.
Hermital or Creon - which is better?
The compositions of these drugs are quite similar, but Ermital is less effective due to the type of active ingredient. Creon mini microgranules easily mix with the contents of the stomach, significantly improving physiological digestion, while other products have a somewhat delayed effect.
Which is better: Creon or Micrasim?
These products are almost identical in everything, but they differ in the dosages of their components.
For example, Micrasim contains 320 mg of pancreatin. In addition, it is a domestically produced medicine and is cheaper.
Therefore, when prescribing this drug, it is important to take into account the high content of the enzyme, since such a difference is noticeable and can lead to complications in the digestive tract.
Creon or Panzinorm - which is better?
Another absolute analogue is Panzinorm . It is produced by the KRKA brand from Slovenia. This medicine is also used in the treatment of enzyme deficiency.
It is believed that each of them has the same effectiveness, and which drug is suitable for treatment, you need to choose yourself, but still on the recommendation of a doctor.
How to use Creon 10000 during gestation and lactation
At the moment, there are no results of clinical trials on the treatment of pregnant women with drugs based on pancreatic enzymes. Testing of these drugs on animals has confirmed their safety for the fetus and a breastfed child.
At the same time, experts advise avoiding independent uncontrolled use of enzyme products by pregnant and lactating women. The appointment should be made by a doctor, taking into account the physiological state of the patient and the characteristics of her health. The expected benefit of taking the drug for the mother must exceed the potential risk to the fetus or newborn.
Reviews about Creon
This drug is quite popular and is discussed on various forums. Reviews about Creon 10000 are especially common, which is prescribed to young children suffering from digestive disorders. Although many mothers do not understand what Creon tablets are for, they try to treat their baby with it.
It is interesting that reviews of Creon 10000 for infants are markedly ambiguous - while some mothers report that the treatment helped them quickly get rid of problems, others call it the most useless medicine. However, it does not cause harm to the child.
Patients are also actively discussing Creon 25000, which is prescribed to patients with digestive system disorders. Numerous reviews of Creon 25000 on forums are also very mixed. While some take it for complex disorders of the digestive system, most take it in cases where problems arise with digesting “heavy” food. One way or another, this allows you to improve the condition of insufficiency of exocrine pancreatic function and other disorders.
By the way, there are reports that some adult patients refuse to use this drug due to the fact that it is produced from pork pancreas. In rare cases, you can find stories about the undesirable effects of this drug, in the form of heaviness and discomfort in the stomach, pain in the gall bladder.
Undoubtedly, patients for whom this drug brought the desired effect and helped reduce the manifestations of severe diseases of the digestive system are not going to stop taking it. An important point of the therapeutic course is to follow a diet with healthy foods and nutrition in normal amounts. With this approach, you can maintain your own health and prevent the development of complications.
Creon price, where to buy
The price of Creon depends on the number of units and the number in the package.
You can buy Creon 10000 tablets in Moscow at a cost of about 300 rubles for 20 pcs. This is the medicine chosen for children.
The price of Creon capsules is 25,000 for 20 pieces. is approximately 600 rubles.
Creon price 40,000 for 50 pcs. starts from 1400 rubles.
The price of Creon 10000 in Ukraine is about 100 UAH.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Creon Micro granules quiche/sol.
5000 units. fl. 20g (included with measuring spoon) Abbott GmbH RUR 1,399 order - Creon 25000 capsules intestinal. 25000 units 20pcs JSC Veropharm
RUR 434 order
- Creon 10000 capsules enteric solution. 10000 units 50 pcs Abbott Laboratories GmbH
RUB 463 order
- Creon 25000 caps. ksh/sol. 25000 units 50pcs JSC Veropharm
938 rub. order
- Creon 10000 caps. ksh/sol 150 mg 20 pcs Abbott Laboratories GmbH
RUB 239 order
Pharmacy Dialogue
- Creon capsules 10000 units No. 50Abbot Laboratories
RUR 681 order
- Creon capsules 40000 units No. 50Abbot Laboratories
RUB 1,412 order
- Creon capsules 10000 units No. 20Abbot Laboratories
320 rub. order
- Creon (caps. 25000 units No. 20)Abbot Laboratories
RUR 556 order
- Creon capsules 25000 units No. 50Abbot Laboratories
RUB 1,269 order
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Pharmacy24
- Creon 10000 150 mg N20 capsules Abbott Laboratories GmbH, Nimetchina
102 UAH.order - Creon 25000 300 mg N20 capsules Abbott, Germany
271 UAH order
- Creon 25000 300 mg N100 capsules Abbott Laboratories GmbH, Nimecchina
1269 UAH. order
PaniPharmacy
- Creon 25,000 capsule Creon 25,000 capsules. 300 mg blister. No. 20 Germany, Abbott Lab.
279 UAH. order
- Creon 10,000 capsule Creon 10,000 capsules. 150 mg No. 20 Germany, Abbott Lab.
102 UAH order
- Creon 10,000 capsule Creon 10,000 capsules. 150 mg blister. No. 20 Germany, Abbott Lab.
116 UAH order
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