Modern life is characterized by high rhythm, as well as increased mental and physical stress. Lack of sleep, constant stress and other negative factors impair memory and reduce concentration. This leads to a deterioration in the quality of life in general. With age, the risks of developing negative deviations increase. The nootropic drug Semax will help stop age-related changes, increase performance and improve memory.
pharmachologic effect
Semax nasal drops 1% is an original synthetic peptide drug, which is an analogue of the ACTH4-10 fragment (methionyl-glutamyl-histidyl-phenylalanyl-prolyl-glycyl-proline), completely devoid of hormonal activity.
All amino acids are L-form. The drug has an original mechanism of neurospecific action on the central nervous system. It is a synthetic analogue of corticotropin, which has nootropic properties and is completely devoid of hormonal activity. The drug improves cognitive processes of the brain, such as memory, learning, attention; increases mental performance. Improves the adaptation of brain cells to hypoxia, anesthesia and other damaging influences.
The drug is practically non-toxic with single and long-term administration. Does not exhibit allergic, embryotoxic, teratogenic and mutagenic properties. Does not have a local irritant effect.
Release form and composition
The nootropic drug Semax belongs to the group of new generation drugs in the class of regulatory peptides. It is produced in the form of nasal drops. 1 ml of the drug contains 1 mg of methionyl-glutamyl-histidyl-phenylalanyl-prolyl-glycyl-proline. This substance has psychostimulating, neuroprotective, antioxidant and antihypoxic effects.
Drops are offered in two forms: bottles with a pipette or complete with a dropper. The volume of the drug is always the same, but the percentage composition of the active substance is different and can be 0.1% and 1%.
Dosage
Semax is used intranasally, using a bottle sealed with a plastic screw cap or a dropper cap.
The volume of 1 drop is 0.05 ml (50 µl). 1 drop of standard solution contains 500 mcg of active substance.
For
moderate
stroke , 2-3 drops are administered into each nostril at one time, which is 2000 (4 drops or 0.2 ml)-3000 mcg (6 drops or 0.3 ml). Instillation is carried out 3-4 times a day with an interval between instillations of 3-4 hours. The daily dose is 6000 (12 drops or 0.6 ml) - 12,000 mcg (24 drops or 1.2 ml).
For severe stroke
At one time, 3-4 drops are administered into each nostril, which is 3000 (6 drops or 0.3 m)-4000 mcg (8 drops or 0.4 ml). Instillation is carried out 4-5 times a day with an interval between instillations of 2.5-3 hours. The daily dose is 12,000 (24 drops or 1.2 ml) - 20,000 mcg (40 drops or 2.0 ml).
The drug is prescribed daily for 10 days.
Mode of application
If the bottle is sealed with a plastic screw cap:
—
For initial use, you must remove the plastic screw cap and replace it with the supplied pipette with cap;
- draw the drug into a pipette;
— slightly tilting your head to the side, squeeze out the required number of drops of the drug onto the mucous membrane of the nasal passage.
If the bottle is sealed with a dropper cap:
—
it is necessary to carefully cut off the tip of the pipette and tightly close the pipette with the cap;
— before use, you should turn the bottle over so that the liquid fills the entire space of the pipette;
- remove the cap and squeeze out the required number of drops of the drug onto the mucous membrane of the nasal passage.
The drug should be kept tightly closed with a capped pipette or plastic screw cap or dropper cap.
When are Semax drops prescribed?
Semax, the instructions for use indicate this, is used when symptoms appear that indicate impairment of memory and intelligence. They occur most often against the background of vascular lesions, traumatic brain injuries, and neurosurgical operations. The drug is indicated during the recovery period after a stroke, for neurotic disorders of various origins and dyscirculatory encephalopathy.
Semax is prescribed, the instructions for use confirm this, in extreme situations when it is necessary to increase the adaptive capabilities of the human body. The medicine is considered effective for the prevention of mental fatigue. It is able to maintain performance during monotonous work or performing operations in stressful situations.
The medicine is used in ophthalmology. He is appointed:
- In the complex treatment of optic nerve atrophy. This disease often leads to vision loss.
- With optic neuritis, which develops against the background of infection or inflammation and is characterized by degradation of visual function.
The product can be used in pediatrics. Drops are indicated for children over 7 years of age to eliminate minimal brain dysfunction. The drug is considered effective for attention deficit hyperactivity disorder.
Drug interactions
Pharmaceutical
Based on the chemical structure of the drug, the presence of chemically incompatible combinations is not expected: the drug is quickly destroyed and does not enter the gastrointestinal tract.
Pharmacokinetic
Considering the chemical structure of the drug (heptapeptide is a synthetic analogue of ACTH, completely devoid of hormonal activity), the rate of absorption and rate of entry into the blood, as well as the intranasal route of administration, the influence of other drugs on the pharmacokinetic parameters of the drug Semax nasal drops 1% is not expected.
Considering the method of administration of Semax nasal drops 1%, it is undesirable to administer agents that have a local vasoconstrictor effect when administered intranasally.
Impact
Semax drops, the instructions confirm this, have a neurometabolic effect on the central nervous system when used in small doses. When used, it is possible to improve attentiveness and stimulate memory development. This allows you to quickly assimilate new information, which means increasing learning rates. In addition, it reduces the body’s negative reactions during oxygen starvation or cerebral ischemia.
The neuroprotective effect of the drug allows you to stop and limit areas of brain damage. As a result, it is possible to increase the effectiveness of restorative therapy for various pathological processes.
With increasing doses of Semax nasal drops, they additionally have antioxidant, angioprotective and antihypotoxic effects. This minimizes the development of problems due to oxygen starvation caused by decreased blood flow to the brain.
The active substance is absorbed from the nasal mucosa at rates of 60-70%. It spreads quickly throughout the body. Therefore, a positive result is obtained even after a single dose in the shortest possible time.
Due to the simple chemical structure of the drug, incompatible combinations with other drugs are excluded. The active substance does not enter the bloodstream through the gastrointestinal tract.
Contraindications and negative reactions of the body
The main contraindications for Semax drops are hypersensitivity to the active component. The medicine is not prescribed to children under 7 years of age. Its use is contraindicated when carrying a child and during breastfeeding. This is due to the fact that studies have not been conducted to prove safety for the fetus and newborn child.
It is necessary to stop using the drug if you confirm:
- Acute psychotic disorders, which are characterized by difficulties assessing reality.
- Conditions of internal anxiety that cause dizziness, panic, muscle tension, shortness of breath.
- History of seizures, characterized by involuntary contraction of muscle groups.
There were no side effects when taking the medication. Sometimes minor irritation of the mucous membrane may occur. Signs of overdose were not affected even with repeated dosage increases.
You can find both positive and negative reviews about the drug. Many patients emphasize that after the course of treatment, memory and concentration have significantly improved. Many also note a positive effect associated with slowing the progression of dementia.
All negative reviews, as a rule, contain information that there is no positive result. Negative side reactions of the body are also often observed, due to which it was necessary to abandon the medicine.
Terms of use
The product is intended for intranasal administration. A pipette or dropper is used to ensure accurate dosage. The recommended amount is 2-3 drops in each nasal passage. If the doctor recommends an increased dosage, then the medicine should be administered with a break of at least 10 minutes.
Recommended dosages for various disorders and pathological conditions are given in the instructions for use. But they can be adjusted by the doctor during the treatment process depending on the patient’s condition and the results obtained.
Semax, 1%, nasal drops, 3 ml, 1 pc.
Semax® has an original mechanism of neurospecific action on the central nervous system.
Semax® has a pronounced neurometabolic effect, which manifests itself even when prescribed in very small doses. Higher doses of Semax®, while maintaining the neurometabolic properties of small doses, have a pronounced antioxidant, antihypoxic, angioprotective and neurotrophic effect. When administered intranasally, Semax® penetrates the BBB within 4 minutes, and the therapeutic effect with a single administration lasts 20–24 hours, which is associated with its sequential degradation, in which most of the effects of the neuropeptide are retained in its fragments.
Neurometabolic
The drug affects processes associated with memory formation and learning. Semax® enhances attention when learning and analyzing information, improves the consolidation of the memory trace; improves the body's adaptation to hypoxia, cerebral ischemia, anesthesia and other damaging influences.
Semax® has a stimulating effect on the population of cholinergic neurons of the basal forebrain ganglia.
The targeted effect of Semax® on cholinergic neurons is accompanied by a significant increase in the activity of the acetylcholinesterase enzyme in specific brain structures, which correlates with an improvement in learning processes and memory formation.
Neuroprotective
Semax® affects the processes of delayed neuronal death, including local inflammation, nitric oxide formation, oxidative stress and dysfunction of trophic factors. Powerful, comparable to the effect of NGF, trophotropic effect of Semax® on neurons of the cholinergic group both in a complete environment and in unfavorable conditions caused by deprivation of glucose and oxygen. Semax® at the gene level includes the synthesis of neurotrophins - regulators of growth and differentiation of nervous tissue (BDNF factor).
Semax® has a direct effect on molecular trigger mechanisms, normalizing the balance of cytokines and increasing the level of anti-inflammatory factors, reducing the formation of nitric oxide, causing inhibition of lipid peroxidation (LPO), activation of the synthesis of superoxide dismutase (SOD) and a decrease in the level of cyclic guasine monophosphate (cGMP) ).
Antioxidant, antihypoxic
Semax® has a positive effect on the body's adaptation to hypoxia. The ability of the drug to stop post-hyperventilation EEG effects caused by a compensatory decrease in cerebral blood flow was discovered.
The drug is practically non-toxic with single and long-term administration. Does not exhibit allergic, embryotoxic, teratogenic and mutagenic properties. Does not have a local irritant effect.
Semax, 1 piece, 3 ml, 0.1%, nasal drops
Semax® has an original mechanism of neurospecific action on the central nervous system.
Semax® has a pronounced neurometabolic effect, which manifests itself even when prescribed in very small doses. Higher doses of Semax®, while maintaining the neurometabolic properties of small doses, have a pronounced antioxidant, antihypoxic, angioprotective and neurotrophic effect. When administered intranasally, Semax® penetrates the BBB within 4 minutes, and the therapeutic effect with a single administration lasts 20–24 hours, which is associated with its sequential degradation, in which most of the effects of the neuropeptide are retained in its fragments.
Neurometabolic
The drug affects processes associated with memory formation and learning. Semax® enhances attention when learning and analyzing information, improves the consolidation of the memory trace; improves the body's adaptation to hypoxia, cerebral ischemia, anesthesia and other damaging influences.
Semax® has a stimulating effect on the population of cholinergic neurons of the basal forebrain ganglia.
The targeted effect of Semax® on cholinergic neurons is accompanied by a significant increase in the activity of the acetylcholinesterase enzyme in specific brain structures, which correlates with an improvement in learning processes and memory formation.
Neuroprotective
Semax® affects the processes of delayed neuronal death, including local inflammation, nitric oxide formation, oxidative stress and dysfunction of trophic factors. Powerful, comparable to the effect of NGF, trophotropic effect of Semax® on neurons of the cholinergic group both in a complete environment and in unfavorable conditions caused by deprivation of glucose and oxygen. Semax® at the gene level includes the synthesis of neurotrophins - regulators of growth and differentiation of nervous tissue (BDNF factor).
Semax® has a direct effect on molecular trigger mechanisms, normalizing the balance of cytokines and increasing the level of anti-inflammatory factors, reducing the formation of nitric oxide, causing inhibition of lipid peroxidation (LPO), activation of the synthesis of superoxide dismutase (SOD) and a decrease in the level of cyclic guasine monophosphate (cGMP) ).
Antioxidant, antihypoxic
Semax® has a positive effect on the body's adaptation to hypoxia. The ability of the drug to stop post-hyperventilation EEG effects caused by a compensatory decrease in cerebral blood flow was discovered.
The drug is practically non-toxic with single and long-term administration. Does not exhibit allergic, embryotoxic, teratogenic and mutagenic properties. Does not have a local irritant effect.
