Focal atrophic gastritis of the stomach: symptoms and treatment

Atrophic gastritis , or the more correct medical name atrophy of the gastric mucosa , is an irreversible process in which the death of cells in the gastric mucosa that produce gastric juice and hydrochloric acid occurs. Atrophy also includes the gradual replacement of stomach cells with connective tissue and cells similar in structure to the cells of the intestinal mucosa.

Atrophy of the gastric mucosa is a dangerous condition for health, since over time and especially in the presence of additional risk factors, it can lead to the development of stomach cancer.

Causes of atrophic gastritis

There are more than ten different causes, each of which can lead to atrophy of the gastric mucosa. Most often, this condition is the result of a long course of inflammation, against the background of chronic gastritis.

Chronic gastritis is a common disease (found in up to 30% of the population in various populations), which has a chronic and recurrent course, manifested by inflammation of the gastric mucosa and confirmed by morphological examination.

The causes of the development of chronic gastritis are:

  • presence of Helicobacter pylori infection (H. pylory);
  • inflammation caused by an autoimmune process, when your own immune system damages the cells of the gastric mucosa;
  • long-term use of medications, such as non-steroidal anti-inflammatory drugs (NSAIDs);
  • doudenogastric reflux, when the contents of the duodenum, including bile, are thrown into the stomach;
  • prolonged contact with harmful substances during work;
  • exposure to radiation;
  • the presence of other chronic diseases, for example, celiac disease, Crohn's disease, sarcoidosis;
  • food allergies;
  • endocrine disorders;
  • other infections (except H. pylori), fungi, parasites.

That is, in most cases, atrophy of the gastric mucosa is the result of the most common (80%) chronic gastritis caused by Helicobacter pylori infection, or autoimmune gastritis, which occurs in 1-2% of cases. This article discusses in detail the atrophy associated with these two causes.

Fully or partially limited products

The diet for atrophic gastritis excludes the use of:

  • Foods that are difficult to digest in the stomach: fatty rough meat and fish, baked goods, raw fruits and vegetables, black bread, smoked meats, mayonnaise, mushrooms, fish/poultry skin, cartilage, fried pies, legumes, margarine, pancakes, fresh milk.
  • Products that contribute to intestinal bloating and increased gas formation: legumes, raw vegetables, okroshka, millet soup.
  • Some types of cereals (corn, millet, barley, pearl barley).
  • Products that irritate the mucous membrane: garlic, salty/smoked foods, fresh onions, hot seasonings, turnips, radishes, radish, canned snack foods, rutabaga.
  • Hot sauces, vinegar, ketchup, pepper and spices.
  • Undiluted fruit/vegetable juices, strong black tea, coffee, sour fruits, kvass, alcoholic beverages.

Table of prohibited products

Proteins, gFats, gCarbohydrates, gCalories, kcal

Vegetables and greens

vegetables legumes9,11,627,0168
swede1,20,17,737
cabbage1,80,14,727
sauerkraut1,80,14,419
green onion1,30,04,619
bulb onions1,40,010,441
cucumbers0,80,12,815
canned cucumbers2,80,01,316
white radish1,40,04,121
turnip1,50,16,230
canned tomatoes1,10,13,520
horseradish3,20,410,556
spinach2,90,32,022
sorrel1,50,32,919

Mushrooms

mushrooms3,52,02,530

Cereals and porridges

corn grits8,31,275,0337
pearl barley9,31,173,7320
millet cereal11,53,369,3348
barley grits10,41,366,3324

Confectionery

candies4,319,867,5453

Ice cream

ice cream3,76,922,1189

Cakes

cake4,423,445,2407

Raw materials and seasonings

mustard5,76,422,0162
ginger1,80,815,880
ketchup1,81,022,293
mayonnaise2,467,03,9627
ground black pepper10,43,338,7251
chilli2,00,29,540

Dairy

kefir3,42,04,751
sour cream2,820,03,2206
curdled milk2,92,54,153

Meat products

pork16,021,60,0259
ham22,620,90,0279

Sausages

dry-cured sausage24,138,31,0455
sausages10,131,61,9332
sausages12,325,30,0277

Bird

smoked chicken27,58,20,0184
duck16,561,20,0346
smoked duck19,028,40,0337
goose16,133,30,0364

Fish and seafood

dried fish17,54,60,0139
smoked fish26,89,90,0196
canned fish17,52,00,088

Oils and fats

animal fat0,099,70,0897
cooking fat0,099,70,0897

Non-alcoholic drinks

bread kvass0,20,05,227
black tea20,05,16,9152
* data is per 100 g of product

What happens to mucosal cells during atrophy?

The gastric mucosa consists of three layers. The top layer covering the entire inner surface of the stomach is formed from cells that produce mucus to protect against the aggressive effects of gastric juice. Beneath it is the most important layer, called the “lamina propria of the stomach.” It contains the glands of the stomach, which produce substances that form gastric juice - hydrochloric acid, pepsin, hormones (internal Castle factor). The third layer contains muscle cells, the main task of which is to ensure the mobility of the gastric mucosa to move food along.

Atrophy of the gastric mucosa affects the upper layer and the lamina propria of the stomach and is an almost irreversible process that can be slowed down if the causes of inflammation are eliminated.

The gastric mucosa is exposed to an aggressive environment, so its cells are completely renewed every three days. The inflammatory process, which develops as a result of the influence of external factors, for example, a bacterial infection or internal causes, for example, the reaction of the immune system, disrupts the process of renewal (regeneration) of cells of the gastric mucosa, including the cells of the gastric glands that produce gastric juice. As a result, the cells of the stomach glands die and are replaced by connective tissue cells, as well as cells similar in structure to intestinal cells.

This process can be diagnosed using histological examination of samples of the gastric mucosa. If only a decrease in the number of cells of the gastric glands is detected, then they speak only of atrophy of the gastric mucosa. If intestinal cells are found in the test sample, then a diagnosis of atrophy with intestinal metaplasia is established. Metaplasia is the appearance of cells that are atypical for a given organ.

Why is eradication necessary?

Eliminating Helicobacter helps:

  • suppress further development, the addition of other bacteria, and the growth of antibiotic-resistant strains;
  • reduce the duration of treatment for gastritis;
  • reduce the negative effects of medications;
  • bring the acidity of gastric juice closer to normal.

The most effective treatment regimens are those that combine tetracycline and penicillin antibiotics and Metronidazole (Trichopol). The modern product De-Nol, a drug based on bismuth citrate, is actively used. Doses are selected individually.

How to correctly diagnose gastric mucosal atrophy?

To diagnose atrophic gastritis, FGDS (gastroscopy) with the collection of at least 5 biopsies (small fragments of mucous membrane) from different parts of the stomach. The number of biopsy samples is determined by the structure of the stomach, since atrophy in different sections develops at different rates, and therefore it is necessary to take samples from all five sections.

The diagnosis is established by a morphologist after a histological examination. Based on this study, treatment is selected and the frequency of examinations is determined for the timely detection of the oncological process.

Also, to assess the severity of atrophy, determination of the activity of the secretory function of the stomach using a laboratory blood test is used - Gastropanel (link).

Diagnosis of Helicobacter pylori infection is carried out using biopsy specimens and a 13C-urease breath test .

For autoimmune gastritis, laboratory diagnostics are carried out using a blood test to determine antibodies to stomach cells and internal Castle factor.

Authorized Products

The diet for atrophic gastritis includes:

  • Concentrated broths based on lean meat/fish/mushrooms and first courses based on them with the addition of finely chopped vegetables and permitted cereals.
  • Lean red meat (beef, pork, lamb), rabbit meat and poultry (chicken, turkey) boiled, baked or stewed (bits, cutlets, zrazy, quenelles).
  • Low-fat fish (hake, pink salmon, cod, pollock, pike) in pieces or in the form of cutlets, meatballs.
  • Dried (yesterday's) wheat bread, dry cookies, uneaten flour products.
  • Broth-based jellied dishes, sauces prepared with meat broths for main courses.
  • Porridges cooked with water/meat broth.
  • Dairy/fermented milk products (kefir, yogurt, curdled milk, sour cream, omelet with cheese, grated cheese, milk, cottage cheese and cream in dishes).
  • Vegetable puree (zucchini, potato, beetroot, pumpkin, carrot, cauliflower), green peas, stewed vegetables with the addition of garden herbs and vegetable oils.
  • Ripe pureed fruits, oranges, baked apples, tangerines, watermelon, peeled grapes.
  • Desserts: marshmallows, marshmallows, jam, marmalade, preserves, honey.
  • Diluted vegetable/fruit juices, tea with lemon, mineral water, coffee and cocoa.

Table of permitted products

Proteins, gFats, gCarbohydrates, gCalories, kcal

Vegetables and greens

zucchini0,60,34,624
cauliflower2,50,35,430
potato2,00,418,180
carrot1,30,16,932
beet1,50,18,840
pumpkin1,30,37,728

Cereals and porridges

semolina10,31,073,3328
cereals11,97,269,3366
white rice6,70,778,9344

Flour and pasta

noodles12,03,760,1322

Bakery products

white bread crackers11,21,472,2331

Confectionery

jam0,30,263,0263
jelly2,70,017,979
marshmallows0,80,078,5304
meringues2,620,860,5440
paste0,50,080,8310
Maria cookies8,78,870,9400

Raw materials and seasonings

honey0,80,081,5329
sugar0,00,099,7398
milk sauce2,07,15,284

Dairy

milk3,23,64,864
cream2,820,03,7205

Cheeses and cottage cheese

cottage cheese17,25,01,8121

Meat products

boiled beef25,816,80,0254
boiled veal30,70,90,0131
rabbit21,08,00,0156

Bird

boiled chicken25,27,40,0170
turkey19,20,70,084

Eggs

chicken eggs12,710,90,7157

Non-alcoholic drinks

mineral water0,00,00,0

Juices and compotes

apricot juice0,90,19,038
jelly0,20,016,768
carrot juice1,10,16,428
pumpkin juice0,00,09,038
rose hip juice0,10,017,670
* data is per 100 g of product

Atrophic gastritis associated with Helicobacter pylori infection

After infection with the bacterium Helicobacter Pylory, inflammation and chronic non-atrophic gastritis develop in the gastric mucosa. At the beginning of the disease, the glands of the stomach produce a sufficient amount of gastric juice. If left untreated, inflammation becomes more active and spreads to all parts of the stomach, leading to mucosal atrophy) and partial replacement of stomach cells with intestinal cells (intestinal metaplasia).

Symptoms

At the onset of the disease, gastritis is asymptomatic. As atrophy progresses, symptoms appear associated with a decrease in the production of hydrochloric acid and other components of gastric juice:

  • loss of appetite,
  • belching of air or rotten belching;
  • nausea;
  • feeling of heaviness and fullness in the stomach;
  • bad breath; salivation, unpleasant taste in the mouth;
  • rumbling, bloating;
  • intolerance to certain foods;
  • unstable stool;
  • dull, aching pain that intensifies after eating;
  • weight loss.

Treatment

Eradication (destruction) of Helicobacter Pylory is the first stage of treatment for this variant of atrophic gastritis.

Reviews and results

Dietary nutrition for atrophic gastritis, according to patients, is of great importance. Therapeutic nutrition is physiologically complete and is prescribed for a long period, however, due to the variety of approved products, patients do not feel significant discomfort.

  • “... I was diagnosed with “chronic atrophic gastritis” 10 years ago, when I was admitted to the hospital with a suspected ulcer. Since then, there have been exacerbations almost every year and dietary nutrition has practically supported me. I usually go on a diet for 2-3 months, and then gradually expand my diet to the menu I’m used to. I don’t feel any particular discomfort while on a diet. Sometimes, of course, I have a desire to eat something from the list of prohibited foods, but I try not to give in to such feelings, because I broke down several times and realized that then I have to start all over again.”
  • “... Atrophic gastritis with low acidity. I have long been accustomed to and adapted to dietary nutrition (Table No. 2). The diet is not complicated, not financially burdensome, especially since you can prepare soups with delicious broths, and foods can be lightly fried and stewed. When there is an exacerbation, I no longer run to the hospital - I immediately go on a diet, drink herbs, and sometimes drugs to stimulate gastric juice. I cook dishes mainly in a double boiler, the cooking process in which is simple and saves a lot of time. Usually after 3-4 weeks the symptoms subside, but I still take precautions and go on a diet for at least 2 months.”

Autoimmune atrophic gastritis

With this type of chronic gastritis, stomach cells are damaged by antibodies produced by the body's own immune system. In this case, chronic inflammation develops, leading to atrophy of the gastric glands and a decrease in the production of hydrochloric acid and internal Castle factor, which ensures the absorption of vitamin B12. A significant decrease in the production of intrinsic factor of Castle can cause anemia B12-deficiency anemia (pernicious anemia) - a disease characterized by impaired hematopoiesis.

Symptoms

The symptoms of autoimmune atrophic gastritis are similar to the symptoms of atrophy caused by Helicobacter pylori infection.

Additionally, anemia develops; autoimmune gastritis can often be accompanied by other autoimmune diseases.

Treatment

There is no specific treatment for autoimmune gastritis; treatment with corticosteroids is used only in exceptional cases.

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