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Lactobacterin por. d/oral/local approx. fl. 5 doses No. 10

Tradename LACTOBACTERIN DRY (Lactobacterinum siccum)

Latin name LACTOBACTERINUM SICCUM

General characteristics Lactobacterin dry is a microbial mass of live lactobacilli, lyophilized in a cultivation medium with the addition of one of the protective media: sucrose-gelatose, milk-sucrose-gelatose or skim milk. Produced in dry form in ampoules or vials (bottles) from 1 to 20 doses and in tablet form. One tablet contains 1 dose. The drug in ampoules or vials (bottles) is a crystalline or porous mass of yellowish-brown color. The tablet is round in shape with flat or slightly convex surfaces from yellowish-gray to beige, “marbling” color is allowed. The drug has a sour milk smell and taste.

Release form Produced in dry form in ampoules or vials (bottles) from 1 to 20 doses and in tablet form. One tablet contains 1 dose.

Pharmacological properties The therapeutic effect of the drug is due to the antagonistic effect of microbial cells of lactobacilli on pathogenic and conditionally pathogenic microorganisms.

Indications for use Lactobacterin dry is intended for the treatment of children and adults suffering from chronic colitis of various etiologies, including nonspecific ulcerative colitis, somatic diseases complicated by dysbacteriosis that arose during the use of antibiotics, sulfonamide drugs and for other reasons, for persons who have suffered acute intestinal infections , in the presence of intestinal dysfunction or the release of pathogenic and conditionally pathogenic bacteria, as well as in obstetric and gynecological practice for the sanitation of the genital tract in the case of nonspecific inflammatory diseases of the genitals and prenatal preparation of pregnant “at-risk” groups with violation of the purity of vaginal secretions up to III-IV degrees. Corrective therapy with lactobacterin can be prescribed after a course of treatment with specific bacteriophages designed to eliminate opportunistic bacteria. Lactobacterin in ampoules and vials (bottles) is prescribed to children from the first months of life, in tablets from 3 years of age.

Method of administration and dosage The main method of using Lactobacterin is through the mouth. The stem of the ampoule is sawed off with a knife and broken off. To avoid glass getting into the ampoule, it is necessary to hold the ampoule with the stem down when breaking it. Remove the metal cap and rubber stopper from the bottle. The contents of the ampoule or vial (bottle) are dissolved with boiled cooled water at the rate of a teaspoon per 1 dose of the drug. Method of dissolution: pour the required number of teaspoons of water into a glass (in accordance with the number of doses indicated on the label (1 teaspoon per 1 dose). Dissolve the drug in an ampoule or vial (bottle) with a small amount of this water. The drug dissolves in no more than 5 minutes , creating a homogeneous mixture of yellowish-brown color with a sour milk smell. Next, the contents of the ampoule, bottle (bottle) are transferred to a glass, mixed, the dissolved drug cannot be stored. Lactobacterin tablets are washed down with boiled water. The drug is taken 40 minutes - 1 hour before meals, it is advisable to drink milk. Treatment is recommended to be accompanied by taking vitamins. Considering the high antibiotic resistance of lactobacilli, the use of lactobacterin does not interfere with antibiotic therapy. LACTOBACTERIN IS USED: a) in the case of protracted and chronic dysentery, with post-dysenteric colitis, after-treatment of convalescents after acute intestinal infections, as well as in the case of prolonged intestinal dysfunction unknown etiology; treatment is carried out for at least 4-6 weeks; b) in the case of nonspecific ulcerative colitis, as well as chronic colitis and enterocolitis, treatment is carried out for up to 1.5-2 months; c) in the case of dysbacteriosis of various etiologies, treatment is carried out for 3-4 weeks. If there is no effect from using the drug within 2 weeks, it is necessary to re-examine the microflora of the gastrointestinal tract and adjust the latter depending on the result obtained. In order to consolidate the obtained clinical effect and in the absence of complete normalization of the microflora, after the end of the course of treatment, a re-examination of the intestinal microflora and, if necessary, maintenance doses of the drug (half the daily dose) are prescribed for 1-1.5 months. For diseases that occur with relapses, repeated courses of treatment are advisable. In these cases, before prescribing the drug, it is necessary to re-examine the microflora. Lactobacterin is used in the following daily doses in adults and children, depending on age: children under 6 months - 1-2 doses; from 6 months to 1 year - 2-3 doses; from 1 year to 3 years - 3-4 doses; after 3 years - 4-10 doses or 4-10 tablets; adults - 6-10 doses or 6-10 tablets. Daily doses can be divided into 2-3 doses. IN OBSTETRIC AND GYNECOLOGICAL PRACTICE LACTOBACTERIN IS USED INTRAVAGINALLY. The contents of the ampoule or vial (bottle) are dissolved in 5 ml of boiled water cooled to room temperature. A cotton or gauze sterile swab is soaked with the resulting mixture of the drug, which is inserted intravaginally and left for 2-3 hours. In the case of inflammatory diseases of the genitals, Lactobacterin is prescribed 3 doses 2 times a day intravaginally for 10-12 days from the 10-12th day of the menstrual cycle. For prenatal preparation of pregnant women at risk, Lactobacterin is prescribed 5-6 doses once a day for 5-8 days. Treatment is carried out under the control of restoration of the purity of vaginal secretions of I-II degrees, the appearance of lactoflora and the disappearance of clinical symptoms of the disease.

Contraindications There are no contraindications to the use of Lactobacterin.

Features of use NOT SUITABLE FOR USE: - a drug whose packaging integrity is damaged (cracked bottles, ampoules). - the drug is not labeled. - a drug with altered physical properties (shrunken dark brown mass, sharply reduced in volume).

Conditions and periods of storage The drug should be stored in a dry, dark place at a temperature of (5±3) oC. Transported by all types of covered transport at a temperature of no more than 10 degrees. C. SHELF LIFE - 12 and 6 months.

Packaging Lactobacterin dry is produced in ampoules of 1-3 doses, vials (bottles) of 5-20 doses. Tablets in bottles of 20 pieces.

In what cases is Lactobacterin prescribed?

The instructions for Lactobacterin contain an extensive list of indications. First of all, these are pathologies of the digestive system associated with an imbalance in the intestinal microflora in patients without age restrictions. The drug is also successfully used in the treatment of diseases of the female reproductive system caused by an imbalance in the vaginal microflora.

For gastrointestinal diseases Lactobacterin is used for:

normalizing the intestinal microflora after an acute intestinal infection or food poisoning in cases where there are symptoms of intestinal malfunction or pathogenic or conditionally pathogenic flora is released in the biomaterial;
therapy for intestinal dysbiosis resulting from long-term use of antibiotics, hormones, or undergoing a course of treatment for cancer;
treatment of chronic colitis;
treatment of infectious and non-infectious diseases, which are accompanied by intestinal dysbiosis and skin manifestations, in children whose body is weakened.

In gynecology, Lactobacterin is prescribed to restore the microflora of the external genitalia after a course of antibiotics for bacterial vaginosis, in the treatment of inflammation of a non-infectious nature. Suppositories are also indicated for:

preparation for surgical interventions or special diagnostics of gynecological pathologies;
carrying out infection prevention after childbirth or after gynecological operations;
prenatal preparation of women at risk and having 3 or 4 degrees of smear purity.

How the drug works

Lactobacterin has a detrimental effect on pathogenic and conditionally pathogenic microbes, including staphylococcus, E. coli, Proteus, and Shigella. Thanks to this, the medicine restores the imbalance in the microbiocenosis of the digestive system and vagina.

Also this drug:

help improve metabolic processes;
serve to prevent the transition of intestinal diseases to a chronic form;
increases the body's innate resistance to the invasion of infectious agents.

After entering the body, lactobacilli:

promote the formation of lactic acid and hydrogen peroxide;
trigger the production of lysozyme and other substances that resemble antibiotics in their activity;
help the absorption of vitamins;
normalize and help maintain the balance of the bacterial flora of the vagina.

How to use Lactobacterin suppositories

The regimen for using suppositories depends on the indications for use:

to normalize vaginal microflora after taking antibiotics, treat non-infectious inflammations - five doses twice a day for 10-12 days;
to prevent the development of infections after childbirth or gynecological operations, during prenatal preparation - 5 doses once a day for a course of 7-8 days.

At the end of the course of treatment, a smear on the flora to determine the effectiveness of treatment.

Dosage forms and composition of the drug

Lactobacterin is available in two forms: lyophilisate for making a suspension and suppositories for use in gynecology.

The lyophilisate is a crystalline powder or porous mass of pale yellow or grayish color, with a specific odor. The dry substance is packaged in bottles, each containing three or five doses. The bottles are placed in cardboard boxes complete with annotation.

One dose contains approximately 2 × 109 CFU of lactobacilli, excipients are gelatin, sucrose and milk.

One suppository contains about 10 million CFU of lactobacilli acidophilus. Candles are packaged in boxes with cells of 5 pieces; they go on sale in 10 pieces in boxes equipped with instructions.

Lactobacterin

Lyophilisate: the contents of the bottle are dissolved with boiled water at room temperature at the rate of 5 ml (teaspoon) of water per 1 dose of the drug: the required amount of water is poured into the glass (in accordance with the number of doses indicated on the bottle); open the bottle by removing the cap and stopper; transfer a small amount of water from the glass to the bottle; after dissolution (the drug dissolves in no more than 5 minutes to form a homogeneous suspension of whitish-gray or yellowish-beige color), the contents of the bottle are transferred to the same glass and mixed. One teaspoon of the drug dissolved in this way is 1 dose.

For intestinal diseases, the drug should be taken 40-60 minutes before meals and preferably washed down with milk. Treatment is recommended to be accompanied by taking vitamins.

For intestinal diseases, the drug is used in the following daily doses depending on age:

Up to 6 months - 3 doses 2 times a day; from 6 months to 1 year 3 doses 3 times a day; from 1 to 3 years 5 doses 2 times a day; over 3 years old and adults - 5 doses 2-3 times a day.

The course of treatment with the drug for various diseases is:

a) for protracted and chronic dysentery, post-dysenteric colitis, after-treatment of convalescents after acute intestinal infections, as well as for long-term intestinal dysfunction of unknown etiology, treatment - at least 4-6 weeks;

b) for nonspecific ulcerative colitis, as well as chronic colitis and enterocolitis - up to 2 months;

c) for dysbacteriosis of various etiologies - 3-4 weeks.

If there is no effect from using the drug for 2 weeks, it is necessary to re-examine the microflora of the gastrointestinal tract and correct it with other drugs, depending on the result obtained.

To consolidate the obtained clinical effect or in the absence of complete normalization of the microflora after the end of the course of treatment, for diseases that occur with relapses, repeated courses of treatment are advisable. In these cases, before prescribing the drug, a repeated study of the microflora is necessary. Maintenance doses of the drug (half the daily dose) are prescribed every 2-3 weeks for 1-1.5 months.

For inflammatory diseases of the genitals, the drug is prescribed 5 doses 2 times a day intravaginally for 10-12 days, starting from the 10-12th day of the menstrual cycle. For prenatal preparation of pregnant women at risk, the drug is prescribed 5 doses once a day for 5-8 days.

For intravaginal use, dissolve the contents of the bottle in 5-10 ml of boiled water at room temperature, soak a sterile tampon with the dissolved drug, insert the tampon into the vagina and leave for 2-3 hours.

Treatment is carried out under the control of restoration of the purity of vaginal secretions to the I-II degree, the appearance of lactoflora and the disappearance of clinical symptoms of the disease.

Tablets are prescribed orally, 30-40 minutes before meals, 2-3 times a day. For acute inflammatory processes, infants - 2-3 tablets, older children and adults - 5 tablets. within 7-8 days; for prolonged and recurrent forms of the disease, infants - 2-3 tablets, older children and adults - 5 tablets. within 14-25 days. For diseases of the oral mucosa - 4-6 tables. by resorption 2-3 times a day for 14-15 days.

Vaginal suppositories:

Before insertion into the vagina, the packaging material is removed from the suppository.

In the treatment of colpitis and vaginal dysbiosis, the drug is prescribed 1-2 suppositories 1 time per day for 5-8 days under the control of restoration of the purity of vaginal secretions to the I-II degree and the disappearance of clinical symptoms of inflammation (if necessary, the course can be continued up to 10-12 days).

In order to prevent purulent-septic complications, use 1 suppository once a day for 5-7 days before the intended operation or delivery.